SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		5 / 9 ILE A 664
ALA A 685
GLU A 704
GLY A 709
LEU A 761
 None
 1.16A 2v0mB-3m6aA:
undetectable		 2v0mB-3m6aA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		5 / 12 LEU A 624
VAL A 613
ILE A 705
VAL A 666
ILE A 664
 None
 0.99A 3mwsB-3m6aA:
undetectable		 3mwsB-3m6aA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		4 / 8 ILE A 742
LEU A 717
MET A 701
GLY A 700
 None
 1.03A 3selX-3m6aA:
undetectable		 3selX-3m6aA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		4 / 5 ASN A 738
ALA A 734
PRO A 735
ALA A 677
 None
 1.33A 3twpD-3m6aA:
undetectable		 3twpD-3m6aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		4 / 6 ALA A 721
ALA A 734
PRO A 735
THR A 702
 None
 1.03A 4dtzB-3m6aA:
undetectable		 4dtzB-3m6aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		4 / 7 GLY A 723
ILE A 745
LEU A 717
PHE A 755
 None
 0.88A 4ejjD-3m6aA:
undetectable		 4ejjD-3m6aA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		6 / 12 ALA A 600
LEU A 609
GLY A 675
PRO A 676
ALA A 678
LYS A 720
 None
 0.82A 4ypmA-3m6aA:
27.3		 4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		6 / 12 ALA A 600
THR A 602
GLY A 675
PRO A 676
ALA A 678
LYS A 720
 None
 1.01A 4ypmA-3m6aA:
27.3		 4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		6 / 12 ALA A 600
THR A 602
MET A 632
GLY A 675
PRO A 676
ALA A 678
 None
 1.19A 4ypmA-3m6aA:
27.3		 4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		5 / 12 THR A 603
LEU A 609
GLY A 675
PRO A 676
ALA A 678
 None
 1.17A 4ypmA-3m6aA:
27.3		 4ypmA-3m6aA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		5 / 12 LEU A 624
VAL A 613
ILE A 705
VAL A 666
ILE A 664
 None
 1.08A 5kqyA-3m6aA:
undetectable		 5kqyA-3m6aA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		5 / 11 LEU A 442
ASP A 443
ILE A 349
GLY A 347
LEU A 461
 None
 0.88A 5twjD-3m6aA:
undetectable		 5twjD-3m6aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3m6a ATP-DEPENDENT
PROTEASE LA 1
(Bacillus
subtilis) 		5 / 9 ILE A 732
ALA A 724
GLY A 723
GLY A 585
TYR A 584
 None
 1.34A 6nm4B-3m6aA:
undetectable		 6nm4B-3m6aA:
16.41