SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 366
ARG A 283
ARG A 343
 None
 0.99A 1l7fA-3m6cA:
undetectable		 1l7fA-3m6cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 366
ARG A 283
ARG A 343
 None
 1.00A 1l7hA-3m6cA:
undetectable		 1l7hA-3m6cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 269
ASN A 263
LEU A 257
LEU A 231
 None
 0.99A 1z95A-3m6cA:
undetectable		 1z95A-3m6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 320
THR A 204
VAL A 212
 None
 0.78A 2q64A-3m6cA:
undetectable		 2q64A-3m6cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 320
THR A 204
VAL A 212
 None
 0.95A 2qakA-3m6cA:
undetectable		 2qakA-3m6cA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 247
ALA A 271
THR A 328
ILE A 330
VAL A 248
 None
 1.27A 2w3aA-3m6cA:
undetectable		 2w3aA-3m6cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 357
ASP A 355
SER A 354
ARG A 360
 None
 1.49A 2z0aC-3m6cA:
1.0		 2z0aC-3m6cA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 321
VAL A 322
PHE A 202
ARG A 320
 None
 1.24A 3bjwF-3m6cA:
undetectable		 3bjwF-3m6cA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 216
ASP A 215
GLY A 333
THR A 328
 None
 0.72A 3el9A-3m6cA:
undetectable		 3el9A-3m6cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 213
THR A 204
LYS A 267
GLY A 242
PRO A 244
 None
 1.45A 3ny4A-3m6cA:
undetectable		 3ny4A-3m6cA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 193
LEU A 246
VAL A 321
LEU A 290
ILE A 330
 None
 0.87A 3tbgD-3m6cA:
undetectable		 3tbgD-3m6cA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 243
PRO A 244
LEU A 245
 None
 0.86A 3tpxE-3m6cA:
undetectable		 3tpxE-3m6cA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 269
ALA A 264
LEU A 260
ALA A 273
ILE A 247
 None
 1.08A 3ut5D-3m6cA:
undetectable		 3ut5D-3m6cA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 190
VAL A 293
LEU A 290
GLY A 192
PHE A 193
 None
 1.11A 3zosA-3m6cA:
undetectable
3zosB-3m6cA:
undetectable		 3zosA-3m6cA:
22.78
3zosB-3m6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 290
GLY A 192
PHE A 187
VAL A 274
LEU A 246
 None
 1.15A 3zosA-3m6cA:
undetectable
3zosB-3m6cA:
undetectable		 3zosA-3m6cA:
22.78
3zosB-3m6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 269
ASN A 263
LEU A 257
LEU A 231
 None
 1.04A 4okwA-3m6cA:
undetectable		 4okwA-3m6cA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 293
LEU A 290
ILE A 191
GLY A 192
VAL A 274
 None
 1.07A 4y8wA-3m6cA:
undetectable		 4y8wA-3m6cA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 293
LEU A 290
ILE A 191
GLY A 192
VAL A 274
 None
 1.05A 4y8wB-3m6cA:
undetectable		 4y8wB-3m6cA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 6 ILE A 330
ALA A 291
THR A 294
VAL A 293
VAL A 248
 None
 1.45A 5eclD-3m6cA:
undetectable		 5eclD-3m6cA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3m6c 60 KDA CHAPERONIN 1
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 301
VAL A 298
VAL A 299
LEU A 246
LEU A 290
 None
 1.23A 6b52A-3m6cA:
undetectable		 6b52A-3m6cA:
21.24