SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 GLY A  54
GLY A 261
GLY A 283
ILE A 282
ILE A  65
 NAD  A 501 (-3.9A)
None
NAD  A 501 (-3.6A)
None
None
 0.79A 2avvA-3m6iA:
undetectable		 2avvA-3m6iA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 GLY A  54
GLY A 261
GLY A 283
ILE A 282
ILE A  65
 NAD  A 501 (-3.9A)
None
NAD  A 501 (-3.6A)
None
None
 0.80A 2fxeA-3m6iA:
undetectable		 2fxeA-3m6iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 PHE A 219
GLY A 215
ASP A 211
ILE A 223
LEU A 330
 None
None
NAD  A 501 (-2.9A)
None
None
 1.02A 2hmyB-3m6iA:
5.3		 2hmyB-3m6iA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 7 SER A  80
ALA A  81
SER A  49
THR A  50
 None
 1.04A 2i91A-3m6iA:
3.6		 2i91A-3m6iA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 7 SER A  80
ALA A  81
SER A  49
THR A  50
 None
 1.04A 2i91B-3m6iA:
3.3		 2i91B-3m6iA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 6 LEU A 172
ILE A 185
VAL A 183
ALA A 199
 None
 0.70A 2j5mA-3m6iA:
undetectable		 2j5mA-3m6iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 LEU A 197
LEU A 165
ILE A 282
GLY A 171
LEU A 172
 None
 1.12A 2j7xA-3m6iA:
undetectable		 2j7xA-3m6iA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 6 LEU A 303
VAL A 281
ILE A 266
ILE A 291
 None
 0.91A 2piwA-3m6iA:
undetectable		 2piwA-3m6iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 6 ILE A 209
CYH A 259
LEU A 330
ILE A 194
 None
 1.02A 2q83B-3m6iA:
undetectable		 2q83B-3m6iA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 ARG A 138
PHE A 127
GLY A  77
HIS A  78
THR A  50
 None
None
None
ZN  A 401 (-3.6A)
None
 1.30A 2xffA-3m6iA:
undetectable		 2xffA-3m6iA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 8 TRP A 147
VAL A 106
CYH A 114
CYH A 122
 None
None
ZN  A 402 (-2.4A)
ZN  A 402 (-2.2A)
 1.27A 2xz5A-3m6iA:
undetectable
2xz5C-3m6iA:
undetectable		 2xz5A-3m6iA:
20.42
2xz5C-3m6iA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 8 TRP A 147
VAL A 106
CYH A 114
CYH A 122
 None
None
ZN  A 402 (-2.4A)
ZN  A 402 (-2.2A)
 1.27A 2xz5C-3m6iA:
undetectable
2xz5D-3m6iA:
undetectable		 2xz5C-3m6iA:
20.42
2xz5D-3m6iA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 5 LEU A 137
THR A  50
THR A  14
HIS A  74
 None
 1.25A 2zj0B-3m6iA:
9.9		 2zj0B-3m6iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		3 / 3 GLY A  77
ASP A  56
SER A  55
 None
None
ZN  A 401 (-4.5A)
 0.71A 3brfA-3m6iA:
undetectable		 3brfA-3m6iA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 9 ALA A 199
VAL A 227
ILE A 209
GLY A 192
ILE A 194
 None
 1.23A 3el4B-3m6iA:
undetectable		 3el4B-3m6iA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 9 PHE A  59
GLY A  63
GLY A  66
CYH A  53
PHE A 344
 None
None
None
ZN  A 401 (-2.0A)
None
 1.18A 3ko0H-3m6iA:
undetectable
3ko0I-3m6iA:
0.0		 3ko0H-3m6iA:
14.89
3ko0I-3m6iA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 7 GLY A  66
CYH A  53
PHE A 344
PHE A  59
 None
ZN  A 401 (-2.0A)
None
None
 1.15A 3ko0L-3m6iA:
undetectable
3ko0N-3m6iA:
undetectable		 3ko0L-3m6iA:
14.89
3ko0N-3m6iA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 9 ALA A 199
GLY A 171
ILE A 282
LEU A 184
VAL A 183
 None
 1.05A 3u7sB-3m6iA:
undetectable		 3u7sB-3m6iA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 8 TRP A 147
VAL A 106
CYH A 114
CYH A 122
 None
None
ZN  A 402 (-2.4A)
ZN  A 402 (-2.2A)
 1.22A 4bqtC-3m6iA:
undetectable
4bqtD-3m6iA:
undetectable		 4bqtC-3m6iA:
20.42
4bqtD-3m6iA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 8 VAL A 106
TYR A 119
CYH A 114
CYH A 122
 None
None
ZN  A 402 (-2.4A)
ZN  A 402 (-2.2A)
 1.11A 4bqtC-3m6iA:
undetectable
4bqtD-3m6iA:
undetectable		 4bqtC-3m6iA:
20.42
4bqtD-3m6iA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 LEU A 197
LEU A 165
ILE A 282
GLY A 171
LEU A 172
 None
 1.13A 4j26A-3m6iA:
undetectable		 4j26A-3m6iA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 VAL A 320
ILE A 194
LEU A 172
LEU A 165
ALA A 201
 None
 1.02A 4m11B-3m6iA:
0.4		 4m11B-3m6iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 TYR A 309
ASN A 120
GLY A 171
ILE A 194
GLY A 192
 None
 1.22A 4obwA-3m6iA:
8.3		 4obwA-3m6iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 7 THR A  50
ARG A 138
GLY A 135
GLY A  77
 None
 0.85A 4rdxA-3m6iA:
undetectable		 4rdxA-3m6iA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 6 ARG A 295
GLU A 238
GLU A 252
VAL A 245
 None
 1.35A 5h4dA-3m6iA:
6.0		 5h4dA-3m6iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 5 PHE A 344
LEU A 337
GLY A  11
ASP A  56
 None
 1.02A 5ik1A-3m6iA:
undetectable		 5ik1A-3m6iA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 7 ILE A 355
LEU A 193
MET A 196
LEU A 197
 None
 0.90A 5u4sA-3m6iA:
8.4		 5u4sA-3m6iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 8 ILE A 355
LEU A 193
MET A 196
LEU A 197
 None
 0.92A 5u4sB-3m6iA:
9.2		 5u4sB-3m6iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		5 / 12 LEU A 162
LEU A 169
ALA A 316
ILE A 194
ALA A 168
 None
 0.98A 5xiwD-3m6iA:
3.8		 5xiwD-3m6iA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3m6i L-ARABINITOL
4-DEHYDROGENASE
(Neurospora
crassa) 		4 / 4 PRO A 164
MET A 154
GLY A 152
VAL A 320
 None
 1.36A 6ak3A-3m6iA:
undetectable		 6ak3A-3m6iA:
13.50