SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 11 LEU A 352
GLY A 364
LEU A 456
LEU A 153
LEU A 130
 None
 1.13A 1mx1A-3m6xA:
undetectable		 1mx1A-3m6xA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 184
GLY A 291
LEU A  25
PRO A 284
PHE A 186
 None
None
None
None
CXM  A   1 ( 4.9A)
 1.12A 1qzzA-3m6xA:
12.1		 1qzzA-3m6xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		6 / 12 ALA A 111
GLY A 113
GLY A 114
LYS A 115
ASP A 135
PRO A 179
 None
 0.52A 1sqfA-3m6xA:
33.6		 1sqfA-3m6xA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 184
GLY A 291
LEU A  25
PRO A 284
PHE A 186
 None
None
None
None
CXM  A   1 ( 4.9A)
 1.12A 1xdsA-3m6xA:
10.5		 1xdsA-3m6xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 184
GLY A 291
LEU A  25
PRO A 284
PHE A 186
 None
None
None
None
CXM  A   1 ( 4.9A)
 1.14A 1xdsB-3m6xA:
10.8		 1xdsB-3m6xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 PHE A 297
THR A 279
VAL A 240
GLY A 239
 None
 0.92A 2a1mA-3m6xA:
undetectable		 2a1mA-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 8 PHE A 297
THR A 279
VAL A 240
GLY A 239
 None
 0.89A 2a1oA-3m6xA:
undetectable		 2a1oA-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 5 LEU A 358
GLY A 136
PRO A 361
ALA A 360
 None
 0.97A 2aohA-3m6xA:
undetectable		 2aohA-3m6xA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 163
ALA A 154
LEU A 153
LEU A 106
VAL A 105
 None
 1.17A 2c12C-3m6xA:
undetectable		 2c12C-3m6xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 114
ASN A 132
ASP A 135
PRO A 179
LEU A 211
 None
 1.09A 2hmyB-3m6xA:
7.2		 2hmyB-3m6xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 173
ARG A 298
ARG A 296
 None
 0.81A 2jb7A-3m6xA:
undetectable
2jb7B-3m6xA:
0.2
2jb7C-3m6xA:
undetectable		 2jb7A-3m6xA:
15.52
2jb7B-3m6xA:
15.52
2jb7C-3m6xA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 296
ARG A 173
ARG A 298
 None
 0.75A 2jb7A-3m6xA:
undetectable
2jb7B-3m6xA:
0.2
2jb7C-3m6xA:
undetectable		 2jb7A-3m6xA:
15.52
2jb7B-3m6xA:
15.52
2jb7C-3m6xA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 298
ARG A 296
ARG A 173
 None
 0.77A 2jb7A-3m6xA:
undetectable
2jb7B-3m6xA:
0.2
2jb7C-3m6xA:
undetectable		 2jb7A-3m6xA:
15.52
2jb7B-3m6xA:
15.52
2jb7C-3m6xA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 GLU A 235
ARG A 281
MET A  10
LEU A  13
 None
 1.18A 2rezA-3m6xA:
undetectable		 2rezA-3m6xA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 PRO A 160
ALA A 215
LEU A 211
ALA A 178
 None
 1.06A 2vcvL-3m6xA:
undetectable		 2vcvL-3m6xA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 PHE A 375
PHE A 441
ALA A 382
ALA A 384
LEU A 334
 None
 1.28A 2x2nB-3m6xA:
undetectable		 2x2nB-3m6xA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 PHE A 375
PHE A 441
ALA A 382
ALA A 384
LEU A 334
 None
 1.26A 2x2nD-3m6xA:
undetectable		 2x2nD-3m6xA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 PHE A 410
PHE A 326
LEU A 332
ALA A 382
PHE A 441
 None
 1.48A 3apxA-3m6xA:
undetectable		 3apxA-3m6xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 LYS A   4
LEU A   7
PHE A  18
LEU A  22
 None
 1.04A 3asoP-3m6xA:
undetectable
3asoW-3m6xA:
undetectable		 3asoP-3m6xA:
19.31
3asoW-3m6xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 5 ILE A  49
SER A  50
PRO A  51
PRO A  53
 None
 1.36A 3bjwC-3m6xA:
undetectable		 3bjwC-3m6xA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 114
ASN A 132
ASP A 135
PRO A 179
LEU A 211
 None
 0.88A 3eeoA-3m6xA:
8.7		 3eeoA-3m6xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 106
PRO A 307
SER A 305
GLY A 351
 None
 0.97A 3hcnA-3m6xA:
undetectable		 3hcnA-3m6xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 106
PRO A 307
SER A 305
GLY A 351
 None
 0.96A 3hcrA-3m6xA:
undetectable		 3hcrA-3m6xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 106
PRO A 307
SER A 305
GLY A 351
 None
 1.00A 3hcrB-3m6xA:
2.1		 3hcrB-3m6xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 11 GLU A 235
LEU A  13
ARG A   9
GLY A 265
LEU A 276
 None
 1.24A 3hm1B-3m6xA:
undetectable		 3hm1B-3m6xA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		7 / 12 ALA A 109
GLY A 113
LYS A 115
PRO A 160
ASP A 177
PRO A 179
LEU A 211
 None
 0.97A 3m6vA-3m6xA:
65.0		 3m6vA-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		12 / 12 ALA A 109
PRO A 112
GLY A 113
GLY A 114
LYS A 115
VAL A 134
ASP A 135
ARG A 138
PRO A 160
ASP A 177
PRO A 179
LEU A 211
 None
 0.47A 3m6vA-3m6xA:
65.0		 3m6vA-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		6 / 12 ALA A 109
GLY A 113
PRO A 160
ASP A 177
PRO A 179
LEU A 211
 None
 0.92A 3m6vB-3m6xA:
65.7		 3m6vB-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		12 / 12 ALA A 109
PRO A 112
GLY A 113
GLY A 114
LYS A 115
VAL A 134
ASP A 135
ARG A 138
PRO A 160
ASP A 177
PRO A 179
LEU A 211
 None
 0.47A 3m6vB-3m6xA:
65.7		 3m6vB-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 114
LYS A 115
ASP A 177
PRO A 179
LEU A 211
 None
 1.10A 3m6vB-3m6xA:
65.7		 3m6vB-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		6 / 12 ALA A 109
GLY A 113
PRO A 160
PRO A 179
VAL A 207
LEU A 211
 None
 0.76A 3m6wA-3m6xA:
66.9		 3m6wA-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		6 / 12 ALA A 109
GLY A 114
LYS A 115
PRO A 179
VAL A 207
LEU A 211
 None
 1.00A 3m6wA-3m6xA:
66.9		 3m6wA-3m6xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		12 / 12 ALA A 109
PRO A 112
GLY A 113
GLY A 114
LYS A 115
VAL A 134
ASP A 135
ARG A 138
PRO A 160
PRO A 179
VAL A 207
LEU A 211
 None
 0.29A 3m6wA-3m6xA:
66.9		 3m6wA-3m6xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 150
ALA A 120
LEU A 389
THR A  38
LEU A  39
 None
 1.10A 3mteA-3m6xA:
8.6		 3mteA-3m6xA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		3 / 3 PHE A  64
SER A  50
GLN A  47
 None
 0.84A 3smtA-3m6xA:
undetectable		 3smtA-3m6xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 113
LYS A 115
ASP A 177
PRO A 179
LEU A 211
 None
 0.92A 4fp9A-3m6xA:
28.8		 4fp9A-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		8 / 12 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
ASP A 177
PRO A 179
LEU A 211
 None
 0.44A 4fp9A-3m6xA:
28.8		 4fp9A-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 113
LYS A 115
ASP A 177
PRO A 179
LEU A 211
 None
 0.92A 4fp9C-3m6xA:
28.8		 4fp9C-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		8 / 12 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
ASP A 177
PRO A 179
LEU A 211
 None
 0.46A 4fp9C-3m6xA:
28.8		 4fp9C-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		7 / 12 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
PRO A 179
LEU A 211
 None
 0.45A 4fp9D-3m6xA:
28.9		 4fp9D-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 113
LYS A 115
ASP A 177
PRO A 179
LEU A 211
 None
 0.92A 4fp9F-3m6xA:
28.7		 4fp9F-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		8 / 12 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
ASP A 177
PRO A 179
LEU A 211
 None
 0.43A 4fp9F-3m6xA:
28.7		 4fp9F-3m6xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		7 / 12 PRO A 112
GLY A 113
GLY A 114
LYS A 115
ASN A 132
PRO A 179
LEU A 211
 None
 0.44A 4fzvA-3m6xA:
28.7		 4fzvA-3m6xA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 8 ALA A 426
PRO A 424
LEU A 449
LEU A 398
 None
 0.96A 4jjkA-3m6xA:
undetectable		 4jjkA-3m6xA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		3 / 3 GLU A  17
ARG A 286
HIS A 285
 None
 0.82A 4kf9A-3m6xA:
undetectable		 4kf9A-3m6xA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 106
PRO A 307
SER A 305
GLY A 351
 None
 0.99A 4klrB-3m6xA:
undetectable		 4klrB-3m6xA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 10 LEU A 355
LEU A 218
ASN A 132
LEU A 108
VAL A 174
 None
 1.06A 4po0A-3m6xA:
undetectable		 4po0A-3m6xA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 THR A 116
ALA A 131
GLY A 124
ALA A 151
THR A 388
 None
 1.17A 4qvnV-3m6xA:
undetectable
4qvnb-3m6xA:
undetectable		 4qvnV-3m6xA:
18.04
4qvnb-3m6xA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 THR A 116
ALA A 131
GLY A 124
ALA A 151
THR A 388
 None
 1.17A 4qvnH-3m6xA:
undetectable
4qvnN-3m6xA:
undetectable		 4qvnH-3m6xA:
18.04
4qvnN-3m6xA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 6 GLU A 403
ILE A  49
THR A 432
HIS A  75
 None
 1.34A 4qwpA-3m6xA:
undetectable		 4qwpA-3m6xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 427
VAL A 416
VAL A 429
ALA A 399
LEU A 400
 None
 0.91A 5kpcA-3m6xA:
9.8		 5kpcA-3m6xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 THR A 116
ALA A 131
GLY A 124
ALA A 151
THR A 388
 None
 1.16A 5lf7V-3m6xA:
undetectable
5lf7b-3m6xA:
undetectable		 5lf7V-3m6xA:
20.48
5lf7b-3m6xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 THR A 116
ALA A 131
GLY A 124
ALA A 151
THR A 388
 None
 1.17A 5lf7H-3m6xA:
undetectable
5lf7N-3m6xA:
undetectable		 5lf7H-3m6xA:
20.48
5lf7N-3m6xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 ALA A 111
PRO A 112
GLY A 114
ASP A 177
LEU A 211
 None
 0.43A 5wwsA-3m6xA:
33.7		 5wwsA-3m6xA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 ALA A 111
PRO A 112
GLY A 114
LYS A 115
ASP A 177
 None
 0.38A 5wwsB-3m6xA:
33.7		 5wwsB-3m6xA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 6 LYS A   4
LEU A   7
PHE A  18
LEU A  22
 None
 1.05A 5x19P-3m6xA:
undetectable		 5x19P-3m6xA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 ALA A 109
PRO A 112
GLY A 114
LYS A 115
PRO A 179
 None
 0.43A 5zvgA-3m6xA:
35.5		 5zvgA-3m6xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 ALA A 109
PRO A 112
GLY A 114
LYS A 115
PRO A 179
 None
 0.43A 5zvgB-3m6xA:
35.5		 5zvgB-3m6xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 334
PHE A 441
LEU A 327
ALA A 330
 None
 0.88A 6a7jA-3m6xA:
undetectable		 6a7jA-3m6xA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		3 / 3 TYR A 346
ALA A 378
LEU A 456
 None
 0.71A 6d9kF-3m6xA:
undetectable		 6d9kF-3m6xA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 THR A 116
ALA A 131
GLY A 124
ALA A 151
THR A 388
 None
 1.16A 6hwdV-3m6xA:
undetectable
6hwdb-3m6xA:
undetectable		 6hwdV-3m6xA:
10.18
6hwdb-3m6xA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 3m6x RRNA METHYLASE
(Thermus
thermophilus) 		5 / 12 THR A 116
ALA A 131
GLY A 124
ALA A 151
THR A 388
 None
 1.15A 6hwdH-3m6xA:
undetectable
6hwdN-3m6xA:
undetectable		 6hwdH-3m6xA:
10.18
6hwdN-3m6xA:
10.48