SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 219
ARG A 151
TYR A 149
THR A  96
 None
 1.39A 1ceaA-3m7dA:
undetectable
1ceaB-3m7dA:
undetectable		 1ceaA-3m7dA:
13.48
1ceaB-3m7dA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 GLU A 175
GLU A 171
LEU A 189
GLU A 186
 None
 1.08A 1linA-3m7dA:
undetectable		 1linA-3m7dA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 TYR A  30
GLU A 129
PHE A  23
PRO A 126
 None
 1.39A 1mclA-3m7dA:
undetectable
1mclB-3m7dA:
undetectable
1mclP-3m7dA:
undetectable		 1mclA-3m7dA:
18.04
1mclB-3m7dA:
18.04
1mclP-3m7dA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.48A 1mskA-3m7dA:
undetectable		 1mskA-3m7dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.41A 1tt6A-3m7dA:
undetectable		 1tt6A-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  25
LEU A 254
LEU A  62
SER A  65
 None
 1.44A 1tz8D-3m7dA:
undetectable		 1tz8D-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.40A 1tz8D-3m7dA:
undetectable		 1tz8D-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 GLU A 171
ILE A 174
GLU A 186
ILE A 181
 None
 0.90A 2j9dJ-3m7dA:
undetectable
2j9dK-3m7dA:
undetectable
2j9dL-3m7dA:
undetectable		 2j9dJ-3m7dA:
16.39
2j9dK-3m7dA:
16.39
2j9dL-3m7dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 GLU A 186
ILE A 181
GLU A 171
ILE A 174
 None
 0.88A 2j9dJ-3m7dA:
undetectable
2j9dK-3m7dA:
undetectable
2j9dL-3m7dA:
undetectable		 2j9dJ-3m7dA:
16.39
2j9dK-3m7dA:
16.39
2j9dL-3m7dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		6 / 12 SER A 222
GLY A 379
LEU A 207
LEU A 209
THR A 198
LEU A 192
 None
 1.48A 2nyuB-3m7dA:
undetectable		 2nyuB-3m7dA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ARG A 102
ASN A 235
THR A  96
 None
 0.70A 2q63A-3m7dA:
undetectable		 2q63A-3m7dA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 VAL A 106
THR A  96
ARG A 144
ILE A 145
SER A 227
 None
 1.47A 2vdyA-3m7dA:
undetectable		 2vdyA-3m7dA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 VAL A 147
LEU A 254
GLY A  26
ALA A  29
 None
 0.92A 2xfsA-3m7dA:
undetectable		 2xfsA-3m7dA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 VAL A 147
LEU A 254
GLY A  26
ALA A  29
 None
 0.93A 2xh9A-3m7dA:
undetectable		 2xh9A-3m7dA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 251
LEU A 254
LYS A  28
GLY A  26
 None
 1.02A 3af0A-3m7dA:
undetectable		 3af0A-3m7dA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 TYR A   5
GLU A 375
ASP A 368
 None
 0.85A 3bxoA-3m7dA:
undetectable		 3bxoA-3m7dA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 232
PHE A 170
ILE A 174
ALA A 141
ILE A 188
 None
 1.10A 3me6A-3m7dA:
undetectable		 3me6A-3m7dA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 GLU A 194
GLU A 171
PHE A 170
PRO A 196
 None
 1.36A 3ql6A-3m7dA:
1.4		 3ql6A-3m7dA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.38A 3vm4A-3m7dA:
undetectable		 3vm4A-3m7dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 7 LYS A  28
LEU A 254
LEU A  62
SER A  65
SER A  69
 None
 1.27A 4ikjA-3m7dA:
undetectable
4ikjB-3m7dA:
undetectable		 4ikjA-3m7dA:
16.99
4ikjB-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 7 SER A  69
LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.28A 4ikkA-3m7dA:
undetectable
4ikkB-3m7dA:
undetectable		 4ikkA-3m7dA:
16.99
4ikkB-3m7dA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 1.03A 4pwjA-3m7dA:
undetectable		 4pwjA-3m7dA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 225
GLY A 224
TYR A 226
HIS A 200
GLU A 202
 None
 1.39A 5igwA-3m7dA:
1.2		 5igwA-3m7dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.38A 5oj0A-3m7dA:
undetectable		 5oj0A-3m7dA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.72A 5qgkA-3m7dA:
undetectable		 5qgkA-3m7dA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.76A 5qgtA-3m7dA:
undetectable		 5qgtA-3m7dA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 318
GLU A 309
LEU A 301
ILE A 307
TYR A 331
 None
 1.34A 5vlmA-3m7dA:
undetectable		 5vlmA-3m7dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 HIS A  56
ALA A 132
TYR A 289
TYR A  30
 None
 1.44A 5yodF-3m7dA:
undetectable		 5yodF-3m7dA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 ARG A 304
ARG A 205
LEU A 301
ALA A 316
 None
 1.08A 6b89B-3m7dA:
undetectable		 6b89B-3m7dA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 11 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.45A 6bm5A-3m7dA:
undetectable		 6bm5A-3m7dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.98A 6e43A-3m7dA:
undetectable		 6e43A-3m7dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.99A 6e43B-3m7dA:
2.0		 6e43B-3m7dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.99A 6e43C-3m7dA:
2.0		 6e43C-3m7dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.97A 6e43D-3m7dA:
undetectable		 6e43D-3m7dA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3m7d TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
PRO A 180
ILE A 181
GLU A 185
 None
 1.21A 6h7uA-3m7dA:
1.6		 6h7uA-3m7dA:
21.79