SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 219
ARG A 151
TYR A 149
THR A  96
 None
 1.39A 1ceaA-3m7gA:
undetectable
1ceaB-3m7gA:
undetectable		 1ceaA-3m7gA:
17.05
1ceaB-3m7gA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 109
GLY A 110
VAL A  27
ALA A 115
PHE A  23
 None
 1.12A 1gseA-3m7gA:
2.2		 1gseA-3m7gA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 TYR A  30
GLU A 129
PHE A  23
PRO A 126
 None
 1.45A 1mclA-3m7gA:
undetectable
1mclB-3m7gA:
undetectable
1mclP-3m7gA:
undetectable		 1mclA-3m7gA:
21.55
1mclB-3m7gA:
21.55
1mclP-3m7gA:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 CYH A  68
PRO A  72
THR A  63
SER A  65
 None
 1.19A 1ymxA-3m7gA:
undetectable		 1ymxA-3m7gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 GLU A 171
ILE A 174
GLU A 186
ILE A 181
 None
 0.83A 2j9dJ-3m7gA:
undetectable
2j9dK-3m7gA:
undetectable
2j9dL-3m7gA:
undetectable		 2j9dJ-3m7gA:
21.76
2j9dK-3m7gA:
21.76
2j9dL-3m7gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 GLU A 186
ILE A 181
GLU A 171
ILE A 174
 None
 0.91A 2j9dJ-3m7gA:
undetectable
2j9dK-3m7gA:
undetectable
2j9dL-3m7gA:
undetectable		 2j9dJ-3m7gA:
21.76
2j9dK-3m7gA:
21.76
2j9dL-3m7gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 251
LEU A 254
LYS A  28
GLY A  26
 None
 0.86A 3af0A-3m7gA:
undetectable		 3af0A-3m7gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 114
ILE A 105
VAL A 147
GLY A 150
ARG A  76
 None
 0.95A 3em0B-3m7gA:
undetectable		 3em0B-3m7gA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 142
ALA A 167
PRO A 163
PRO A 156
 None
 1.18A 3gv1A-3m7gA:
undetectable
3gv1B-3m7gA:
undetectable		 3gv1A-3m7gA:
16.91
3gv1B-3m7gA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 LEU A 138
LEU A 142
ARG A 151
 None
 0.71A 3hcnB-3m7gA:
undetectable		 3hcnB-3m7gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 232
PHE A 170
ILE A 174
ALA A 141
ILE A 188
 None
 1.08A 3me6A-3m7gA:
undetectable		 3me6A-3m7gA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.46A 3vm4A-3m7gA:
undetectable		 3vm4A-3m7gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.47A 3w9tA-3m7gA:
undetectable		 3w9tA-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.46A 3w9tB-3m7gA:
undetectable		 3w9tB-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.47A 3w9tC-3m7gA:
undetectable		 3w9tC-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.47A 3w9tD-3m7gA:
undetectable		 3w9tD-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.47A 3w9tE-3m7gA:
undetectable		 3w9tE-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.48A 3w9tF-3m7gA:
undetectable		 3w9tF-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  10
GLY A  11
TYR A  77
ASP A  71
 None
 1.47A 3w9tG-3m7gA:
undetectable		 3w9tG-3m7gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.94A 4pwjA-3m7gA:
undetectable		 4pwjA-3m7gA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.89A 4pwjB-3m7gA:
undetectable		 4pwjB-3m7gA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.87A 5bojB-3m7gA:
undetectable		 5bojB-3m7gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.63A 5qgkA-3m7gA:
undetectable		 5qgkA-3m7gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.66A 5qgrA-3m7gA:
undetectable		 5qgrA-3m7gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.68A 5qgtA-3m7gA:
undetectable		 5qgtA-3m7gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.98A 6e43A-3m7gA:
undetectable		 6e43A-3m7gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.99A 6e43B-3m7gA:
1.9		 6e43B-3m7gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.99A 6e43C-3m7gA:
1.7		 6e43C-3m7gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.98A 6e43D-3m7gA:
undetectable		 6e43D-3m7gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3m7g TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
PRO A 180
ILE A 181
GLU A 185
 None
 1.23A 6h7uA-3m7gA:
undetectable		 6h7uA-3m7gA:
19.59