SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 8 ARG A 592
GLU A 596
HIS A 535
TYR A 366
 None
ZN  A 955 ( 3.9A)
ZN  A 954 (-3.2A)
12P  A 189 ( 4.7A)
 1.28A 1nx9A-3m7pA:
undetectable		 1nx9A-3m7pA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 8 ARG A 592
GLU A 596
HIS A 535
TYR A 366
 None
ZN  A 955 ( 3.9A)
ZN  A 954 (-3.2A)
12P  A 189 ( 4.7A)
 1.27A 1nx9B-3m7pA:
undetectable		 1nx9B-3m7pA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 8 ARG A 592
GLU A 596
HIS A 535
TYR A 366
 None
ZN  A 955 ( 3.9A)
ZN  A 954 (-3.2A)
12P  A 189 ( 4.7A)
 1.29A 1nx9C-3m7pA:
undetectable		 1nx9C-3m7pA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 8 ARG A 592
GLU A 596
HIS A 535
TYR A 366
 None
ZN  A 955 ( 3.9A)
ZN  A 954 (-3.2A)
12P  A 189 ( 4.7A)
 1.29A 1nx9D-3m7pA:
undetectable		 1nx9D-3m7pA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 474
HIS A 488
HIS A 581
 ZN  A 959 (-2.3A)
ZN  A 959 (-3.0A)
ZN  A 959 (-3.0A)
 0.70A 1oe2A-3m7pA:
undetectable		 1oe2A-3m7pA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 4 ASP A 381
GLU A 377
ARG A 592
TYR A 392
 ZN  A 956 ( 4.4A)
ZN  A 955 ( 4.3A)
None
None
 1.29A 1wsvB-3m7pA:
0.0		 1wsvB-3m7pA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 7 THR A 507
ASN A 501
ASP A 522
HIS A 539
 None
None
None
ZN  A 955 (-4.9A)
 1.01A 3t01A-3m7pA:
undetectable		 3t01A-3m7pA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1001_0
(FORMIN-LIKE PROTEIN
3)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 527
ASN A 526
ASN A 473
ARG A 534
 None
None
None
NAG  A1528 ( 4.8A)
 1.50A 4eahA-3m7pA:
undetectable
4eahE-3m7pA:
undetectable		 4eahA-3m7pA:
17.85
4eahE-3m7pA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1003_0
(FORMIN-LIKE PROTEIN
3)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 5 ASN A 473
ARG A 534
VAL A 527
ASN A 526
 None
NAG  A1528 ( 4.8A)
None
None
 1.50A 4eahA-3m7pA:
undetectable
4eahE-3m7pA:
undetectable		 4eahA-3m7pA:
17.85
4eahE-3m7pA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_B_ACTB1001_0
(FORMIN-LIKE PROTEIN
3)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 527
ASN A 526
ASN A 473
ARG A 534
 None
None
None
NAG  A1528 ( 4.8A)
 1.44A 4eahB-3m7pA:
undetectable
4eahC-3m7pA:
undetectable		 4eahB-3m7pA:
17.85
4eahC-3m7pA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 377
GLU A 537
ARG A 592
GLU A 596
 ZN  A 955 ( 4.3A)
ZN  A 955 (-2.6A)
None
ZN  A 955 ( 3.9A)
 1.36A 4kr3A-3m7pA:
undetectable		 4kr3A-3m7pA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		5 / 10 THR A 507
GLY A 502
GLY A 504
VAL A 499
GLU A 467
 None
None
None
None
ZN  A 953 (-2.0A)
 1.25A 6nqaK-3m7pA:
undetectable		 6nqaK-3m7pA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3m7p FN1 PROTEIN
(Homo
sapiens) 		5 / 10 THR A 524
GLY A 502
GLY A 504
VAL A 499
GLU A 467
 None
None
None
None
ZN  A 953 (-2.0A)
 1.04A 6nqaK-3m7pA:
undetectable		 6nqaK-3m7pA:
18.35