SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 7 LYS A 160
THR A  86
SER A  77
THR A  79
 None
 0.66A 1ictD-3m8uA:
undetectable		 1ictD-3m8uA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.04A 1kiaA-3m8uA:
undetectable		 1kiaA-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.05A 1kiaB-3m8uA:
undetectable		 1kiaB-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.06A 1kiaC-3m8uA:
undetectable		 1kiaC-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 6 TRP A 410
SER A  32
ASN A  29
SER A  48
 None
 1.42A 1kiaC-3m8uA:
undetectable		 1kiaC-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 414
GLY A 428
ALA A 499
GLY A 425
TYR A 413
 MLI  A   3 ( 3.9A)
GDS  A   1 (-3.6A)
None
None
None
 1.04A 1nbhB-3m8uA:
undetectable		 1nbhB-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 5 LEU A 260
VAL A 511
TYR A 514
THR A 507
 None
 1.23A 1nw3A-3m8uA:
2.1		 1nw3A-3m8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 7 ILE A 242
PRO A  35
PHE A  38
ALA A  51
 None
 1.16A 1oniD-3m8uA:
undetectable
1oniE-3m8uA:
undetectable		 1oniD-3m8uA:
15.31
1oniE-3m8uA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 6 PHE A  38
ALA A  51
ILE A 242
PRO A  35
 None
 1.09A 1oniH-3m8uA:
undetectable
1oniI-3m8uA:
undetectable		 1oniH-3m8uA:
15.31
1oniI-3m8uA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 7 THR A 206
PHE A  97
SER A  53
LEU A  91
 None
 1.09A 1qcaA-3m8uA:
undetectable		 1qcaA-3m8uA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 LEU A 440
LEU A 443
LEU A 462
ALA A 485
ILE A 288
 None
 1.13A 1tw4A-3m8uA:
undetectable		 1tw4A-3m8uA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 7 TYR A 427
GLY A 420
THR A 417
TYR A 413
 None
 1.02A 2g70A-3m8uA:
undetectable		 2g70A-3m8uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 7 TYR A 427
GLY A 420
THR A 417
TYR A 413
 None
 1.03A 2g70B-3m8uA:
undetectable		 2g70B-3m8uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 7 PHE A 368
SER A 403
PHE A 300
ILE A 372
 None
 1.01A 2v0mC-3m8uA:
undetectable		 2v0mC-3m8uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 6 LEU A 334
ALA A 485
LEU A 466
ALA A 469
 None
 0.91A 2vcvB-3m8uA:
undetectable		 2vcvB-3m8uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 6 LEU A 334
ALA A 485
LEU A 466
ALA A 469
 None
 0.91A 2vcvK-3m8uA:
undetectable		 2vcvK-3m8uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 9 VAL A 399
GLY A 400
GLY A 367
LEU A 358
ALA A 355
 None
 0.95A 2z0yB-3m8uA:
undetectable		 2z0yB-3m8uA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 GLY A 205
GLY A 207
ILE A 181
ARG A  59
LEU A 210
 None
 1.05A 3ckkA-3m8uA:
undetectable		 3ckkA-3m8uA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		3 / 3 ASN A 100
HIS A  98
VAL A  56
 None
 0.86A 3elzB-3m8uA:
undetectable		 3elzB-3m8uA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 4 PRO A 196
THR A 198
GLY A  37
THR A  36
 None
 1.01A 3ib1A-3m8uA:
2.4		 3ib1A-3m8uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 4 PRO A 196
THR A 198
GLY A 205
THR A 206
 None
 1.00A 3ib1A-3m8uA:
2.4		 3ib1A-3m8uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		3 / 3 PRO A 383
PHE A 504
ALA A 326
 None
 0.58A 3itaD-3m8uA:
undetectable		 3itaD-3m8uA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		3 / 3 THR A 206
ASP A 113
GLU A 185
 None
 0.69A 3qowA-3m8uA:
undetectable		 3qowA-3m8uA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 11 HIS A 225
GLY A 205
SER A 183
PHE A 103
MET A 190
 None
 1.21A 3v3nD-3m8uA:
undetectable		 3v3nD-3m8uA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 LEU A 163
LEU A 122
PHE A  89
LEU A 174
ALA A  41
 None
 1.08A 3vw7A-3m8uA:
undetectable		 3vw7A-3m8uA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		3 / 3 LEU A 334
PRO A 335
ARG A 478
 None
 0.70A 4klrB-3m8uA:
undetectable		 4klrB-3m8uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 6 SER A 403
GLU A 397
VAL A 374
THR A 426
 None
 1.25A 4lnxA-3m8uA:
undetectable		 4lnxA-3m8uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 GLY A 205
TYR A 182
SER A  52
ASN A  58
TYR A 228
 None
 1.30A 4ymgB-3m8uA:
undetectable		 4ymgB-3m8uA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		3 / 3 THR A 206
ASP A 113
GLU A 185
 None
 0.82A 5fa8A-3m8uA:
undetectable		 5fa8A-3m8uA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 288
GLY A 428
HIS A 500
ILE A 318
MET A 388
 None
GDS  A   1 (-3.6A)
None
None
None
 1.07A 5igvA-3m8uA:
undetectable		 5igvA-3m8uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		5 / 12 ILE A 288
GLY A 428
HIS A 500
ILE A 318
MET A 388
 None
GDS  A   1 (-3.6A)
None
None
None
 0.98A 5igwA-3m8uA:
undetectable		 5igwA-3m8uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 6 GLY A 207
THR A 206
TYR A 228
ASN A  58
 None
 0.75A 5k4pA-3m8uA:
undetectable		 5k4pA-3m8uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		4 / 5 ARG A 249
THR A 247
ALA A 248
ASP A 245
 None
 1.32A 5mfxA-3m8uA:
undetectable		 5mfxA-3m8uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3m8u HEME-BINDING PROTEIN
A
(Glaesserella
parasuis) 		3 / 3 ASP A 200
SER A  48
SER A  52
 None
 0.82A 6mxtA-3m8uA:
undetectable		 6mxtA-3m8uA:
20.49