SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3m99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 386
LEU A 316
ILE A 416
THR A 466
ILE A 414
 None
 1.21A 1hzeA-3m99A:
undetectable
1hzeB-3m99A:
undetectable		 1hzeA-3m99A:
11.36
1hzeB-3m99A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		5 / 9 THR A 466
ILE A 414
LEU A 386
LEU A 316
ILE A 416
 None
 1.21A 1hzeA-3m99A:
undetectable
1hzeB-3m99A:
undetectable		 1hzeA-3m99A:
11.36
1hzeB-3m99A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 359
VAL A 455
ILE A 429
ILE A 450
 None
 0.72A 1uwhA-3m99A:
undetectable		 1uwhA-3m99A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 183
LEU A 152
LEU A 220
ALA A 223
 None
 0.98A 2vcvK-3m99A:
undetectable		 2vcvK-3m99A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 464
ASN A 158
PHE A 279
 None
 0.79A 2zbuD-3m99A:
undetectable		 2zbuD-3m99A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 136
VAL A 191
ARG A 132
 None
 0.80A 3b0wB-3m99A:
undetectable		 3b0wB-3m99A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 140
GLN A 153
ILE A 217
LEU A 136
 None
 1.31A 3dzyD-3m99A:
undetectable		 3dzyD-3m99A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 110
ARG A  28
ASN A  25
ALA A 115
 None
 1.45A 3frqA-3m99A:
undetectable		 3frqA-3m99A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 463
VAL A 455
LEU A 316
TYR A 465
 None
 1.10A 3v81A-3m99A:
undetectable		 3v81A-3m99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 5 SER A 137
GLN A 213
SER A 445
VAL A 447
 None
 1.45A 4a99D-3m99A:
undetectable		 4a99D-3m99A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 416
PHE A 431
TRP A 439
SER A 448
 None
 1.26A 5nr3A-3m99A:
undetectable		 5nr3A-3m99A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 138
LEU A 139
GLN A 153
ALA A 430
PHE A 442
 None
 0.19A 5xu8A-3m99A:
30.8		 5xu8A-3m99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 138
LEU A 139
SER A 150
GLN A 153
PHE A 442
 None
 0.46A 5xu8A-3m99A:
30.8		 5xu8A-3m99A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  33
ASN A  32
LEU A  31
 None
 0.88A 6f7lB-3m99A:
undetectable		 6f7lB-3m99A:
20.69