SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 PHE A 331
ILE A 277
ASN A 278
VAL A 252
PHE A 397
 None
 1.21A 2zzmA-3maeA:
undetectable		 2zzmA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 PHE A 331
GLY A 329
ILE A 277
VAL A 252
PHE A 397
 None
 1.30A 2zznA-3maeA:
undetectable		 2zznA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 PHE A 331
ILE A 277
ASN A 278
VAL A 252
PHE A 397
 None
 1.22A 2zznA-3maeA:
undetectable		 2zznA-3maeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 PHE A 245
VAL A 358
ALA A 282
VAL A 218
ILE A 401
 PO4  A  11 ( 4.9A)
PO4  A  11 (-4.1A)
GOL  A 426 ( 4.8A)
None
None
 1.13A 3czhA-3maeA:
undetectable		 3czhA-3maeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		4 / 5 SER A 322
PRO A 292
TYR A 290
VAL A 293
 None
 1.39A 3sufC-3maeA:
undetectable		 3sufC-3maeA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ILE A 302
ALA A 246
PHE A 245
LYS A 407
LEU A 223
 None
None
PO4  A  11 ( 4.9A)
None
None
 1.25A 3ti1A-3maeA:
undetectable		 3ti1A-3maeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 PHE A 397
ILE A 277
ILE A 279
ALA A 251
VAL A 333
 None
 0.99A 4nkvB-3maeA:
undetectable		 4nkvB-3maeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 11 LEU A 262
PHE A 331
GLN A 352
ALA A 353
ILE A 281
 None
 1.35A 4uuuA-3maeA:
undetectable
4uuuB-3maeA:
undetectable		 4uuuA-3maeA:
20.16
4uuuB-3maeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 11 LEU A 262
PHE A 331
GLN A 352
ALA A 353
ILE A 294
 None
 1.31A 4uuuA-3maeA:
undetectable
4uuuB-3maeA:
undetectable		 4uuuA-3maeA:
20.16
4uuuB-3maeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 11 LEU A 262
PHE A 331
GLN A 352
ALA A 353
ILE A 294
 None
 1.28A 4uuuB-3maeA:
undetectable		 4uuuB-3maeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		4 / 5 HIS A 211
ILE A 209
SER A 383
ALA A 353
 CL  A   1 (-4.3A)
None
None
None
 1.25A 5msdA-3maeA:
undetectable		 5msdA-3maeA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
(Listeria
monocytogenes) 		3 / 3 THR A 265
HIS A 274
ASN A 263
 GOL  A 425 ( 4.7A)
GOL  A 425 (-3.5A)
None
 0.96A 5n4tA-3maeA:
undetectable		 5n4tA-3maeA:
23.05