SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3maj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 8 MET A 123
LEU A 183
VAL A  87
GLY A  86
 None
 1.05A 1hrkA-3majA:
undetectable		 1hrkA-3majA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		6 / 12 GLY A 185
GLY A 186
VAL A  87
LEU A 215
LEU A 230
LEU A  89
 None
 1.45A 1ya4C-3majA:
undetectable		 1ya4C-3majA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 198
LEU A 162
GLY A 165
ASP A 167
ALA A 169
 None
 1.15A 2br4E-3majA:
undetectable		 2br4E-3majA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 152
LEU A 147
ALA A 154
SER A 235
GLY A 237
 None
 1.00A 2vmyB-3majA:
undetectable		 2vmyB-3majA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 152
LEU A 147
ALA A 154
SER A 235
GLY A 237
 None
 1.02A 2vmyA-3majA:
undetectable		 2vmyA-3majA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 132
ALA A 170
ALA A 136
ALA A 239
VAL A 240
 None
 1.09A 3jb3A-3majA:
undetectable		 3jb3A-3majA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 10 LEU A 147
VAL A 131
ILE A 231
VAL A 236
ILE A 130
 None
 1.00A 3oxwB-3majA:
undetectable		 3oxwB-3majA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 268
VAL A 266
ALA A 243
ALA A 244
LEU A 271
 None
None
None
SO4  A 401 ( 4.5A)
None
 0.94A 3p2kC-3majA:
undetectable		 3p2kC-3majA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 268
VAL A 266
ALA A 243
ALA A 244
LEU A 271
 None
None
None
SO4  A 401 ( 4.5A)
None
 0.94A 3p2kD-3majA:
undetectable		 3p2kD-3majA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 6 LEU A 230
SER A 232
ALA A 256
ARG A 255
LEU A 101
 None
None
None
SO4  A 402 (-2.8A)
None
 1.04A 3ravA-3majA:
undetectable		 3ravA-3majA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 6 SER A 232
ALA A 256
ARG A 255
LEU A 101
 None
None
SO4  A 402 (-2.8A)
None
 0.96A 3rd0A-3majA:
undetectable		 3rd0A-3majA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 11 ALA A 173
HIS A 171
VAL A 158
GLY A 152
ALA A 153
 None
 0.97A 3sm2B-3majA:
undetectable		 3sm2B-3majA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 7 LEU A 111
SER A 211
GLU A  78
HIS A 187
 None
 1.13A 4aq7A-3majA:
1.6		 4aq7A-3majA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 ASP A 167
VAL A 131
VAL A 180
ALA A 253
LEU A 101
 None
 1.35A 4nc3A-3majA:
undetectable		 4nc3A-3majA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		3 / 3 ILE A 302
ASP A 327
ARG A 261
 None
 0.83A 4pstA-3majA:
undetectable		 4pstA-3majA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 11 LEU A 101
PHE A  37
GLY A 112
LEU A  89
LEU A 230
 None
 1.14A 4wnuA-3majA:
undetectable		 4wnuA-3majA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 7 ILE A  41
PHE A  37
ARG A  25
LEU A  15
 None
 0.94A 5b3sN-3majA:
undetectable
5b3sW-3majA:
undetectable		 5b3sN-3majA:
23.81
5b3sW-3majA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 248
LEU A 147
PHE A 143
ASP A 167
 None
 0.71A 5hieB-3majA:
undetectable		 5hieB-3majA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 10 ARG A  20
LEU A 110
ALA A 107
GLY A 350
ILE A 346
 None
 1.07A 5kr1A-3majA:
undetectable		 5kr1A-3majA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 GLN A 168
ALA A 169
LEU A 198
ILE A 202
VAL A 158
 None
 1.30A 5vlmB-3majA:
undetectable		 5vlmB-3majA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 8 ILE A  41
PHE A  37
ARG A  25
LEU A  15
 None
 0.92A 5xdxN-3majA:
undetectable
5xdxW-3majA:
undetectable		 5xdxN-3majA:
23.81
5xdxW-3majA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 8 ILE A  41
PHE A  37
ARG A  48
LEU A  15
 None
 0.75A 5zcoA-3majA:
undetectable
5zcoJ-3majA:
undetectable		 5zcoA-3majA:
23.81
5zcoJ-3majA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 335
LEU A 363
SER A 352
LEU A 345
ILE A 346
 None
 0.96A 6ecxA-3majA:
undetectable		 6ecxA-3majA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3maj DNA PROCESSING CHAIN
A
(Rhodopseudomonas
palustris) 		4 / 6 ILE A 104
ALA A 234
ARG A 100
ASP A 327
 None
 1.16A 6hu9m-3majA:
undetectable
6hu9q-3majA:
undetectable		 6hu9m-3majA:
22.18
6hu9q-3majA:
14.14