SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		6 / 10 GLN A 166
ILE A 202
LEU A  54
VAL A 191
VAL A  70
LEU A 116
 None
 1.47A 3gwxA-3malA:
undetectable		 3gwxA-3malA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 HIS A 177
CYH A 192
ILE A 194
HIS A 175
 None
 1.25A 3qpkA-3malA:
undetectable		 3qpkA-3malA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 4 HIS A 177
CYH A 192
ILE A 194
HIS A 175
 None
 1.26A 3qpkB-3malA:
undetectable		 3qpkB-3malA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 GLY A 143
ASP A 141
ARG A 106
GLN A  68
 None
 1.40A 3qx3A-3malA:
undetectable		 3qx3A-3malA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 GLY A 143
ASP A 141
ARG A 106
GLN A  68
 None
 1.45A 3qx3B-3malA:
undetectable		 3qx3B-3malA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		5 / 9 HIS A 177
SER A 176
GLN A 189
VAL A 131
GLY A  72
 None
 1.48A 3tehA-3malA:
undetectable		 3tehA-3malA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 VAL A 163
LEU A 148
LEU A 165
ILE A  43
 None
 0.81A 3u5kD-3malA:
undetectable		 3u5kD-3malA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 VAL A 163
LEU A 148
LEU A 165
ILE A  43
 None
 0.94A 4a9jB-3malA:
undetectable		 4a9jB-3malA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 VAL A 163
LEU A 148
LEU A 165
ILE A  43
 None
 0.93A 4a9jC-3malA:
undetectable		 4a9jC-3malA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 150
GLN A 161
ILE A 105
ALA A 103
ILE A  37
 None
SO4  A   1 (-4.0A)
None
None
None
 1.24A 4rp8C-3malA:
undetectable		 4rp8C-3malA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 TYR A  61
SER A 123
SER A 132
HIS A 119
 None
 0.83A 4wryA-3malA:
undetectable		 4wryA-3malA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 TYR A  61
SER A 123
SER A 132
HIS A 119
 None
 0.87A 4wrzA-3malA:
undetectable		 4wrzA-3malA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 TYR A  61
SER A 123
SER A 132
HIS A 119
 None
 0.88A 4ws1A-3malA:
undetectable		 4ws1A-3malA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 PHE A  73
SER A  56
HIS A 109
LEU A  54
 None
 1.40A 5dzka-3malA:
undetectable
5dzko-3malA:
undetectable		 5dzka-3malA:
19.65
5dzko-3malA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 174
CYH A 133
HIS A 117
LEU A 116
 None
 1.17A 5hpuC-3malA:
undetectable
5hpuD-3malA:
undetectable		 5hpuC-3malA:
9.17
5hpuD-3malA:
11.66