SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		3 / 3 PRO A 213
ASP A 206
ASP A 151
 None
 0.66A 1sqfA-3mamA:
undetectable		 1sqfA-3mamA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 106
PHE A 107
ASP A 244
THR A 192
 None
None
None
EPE  A 278 (-4.5A)
 1.12A 2aouB-3mamA:
undetectable		 2aouB-3mamA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  98
ILE A  71
LEU A  72
LEU A  52
TYR A  60
 None
 1.21A 3cs8A-3mamA:
undetectable		 3cs8A-3mamA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 108
ASP A 239
ASP A 215
 None
 0.90A 3jayA-3mamA:
undetectable		 3jayA-3mamA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  42
GLY A  11
SER A  12
LEU A  52
ALA A  67
 None
 1.22A 3ou6C-3mamA:
undetectable		 3ou6C-3mamA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 11 PHE A 164
ALA A 135
VAL A 186
LEU A 113
LEU A 204
 None
 1.16A 4zmeA-3mamA:
undetectable		 4zmeA-3mamA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 10 PHE A 164
ALA A 135
VAL A 186
LEU A 113
LEU A 204
 None
 1.16A 4zmeB-3mamA:
undetectable		 4zmeB-3mamA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 115
VAL A 186
PHE A 164
ILE A 156
LEU A 204
 None
 1.24A 5e4dA-3mamA:
undetectable		 5e4dA-3mamA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 164
ILE A 156
LEU A 131
LEU A 204
VAL A 115
 None
 1.25A 5im2A-3mamA:
8.1		 5im2A-3mamA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3mam OSMOPROTECTION
PROTEIN (PROX)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  11
TYR A  19
PHE A 107
LEU A 105
MET A 246
 None
 1.30A 5kklB-3mamA:
undetectable		 5kklB-3mamA:
15.12