SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 10 HIS A  48
THR A  49
GLN A  50
TYR A  84
ASP A 224
 None
PXL  A 400 (-2.9A)
PXL  A 400 (-4.0A)
PXL  A 400 (-3.7A)
PXL  A 400 (-2.4A)
 0.30A 1td2A-3mbhA:
34.0		 1td2A-3mbhA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 9 HIS A  48
THR A  49
TYR A  84
VAL A 113
ASP A 224
 None
PXL  A 400 (-2.9A)
PXL  A 400 (-3.7A)
PXL  A 400 (-4.4A)
PXL  A 400 (-2.4A)
 0.40A 1td2B-3mbhA:
34.3		 1td2B-3mbhA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A  40
VAL A 129
MET A 128
ILE A  91
 None
 1.01A 2hyyC-3mbhA:
undetectable		 2hyyC-3mbhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 8 PRO A 112
THR A 143
PRO A 144
VAL A 181
ALA A 139
 None
 1.48A 2v32A-3mbhA:
undetectable
2v32B-3mbhA:
undetectable		 2v32A-3mbhA:
23.97
2v32B-3mbhA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 9 THR A 143
PRO A 144
VAL A 181
ALA A 139
PRO A 112
 None
 1.48A 2v41A-3mbhA:
undetectable
2v41B-3mbhA:
undetectable		 2v41A-3mbhA:
23.97
2v41B-3mbhA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 9 PRO A 112
THR A 143
PRO A 144
VAL A 181
ALA A 139
 None
 1.46A 2v41A-3mbhA:
undetectable
2v41B-3mbhA:
undetectable		 2v41A-3mbhA:
23.97
2v41B-3mbhA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 121
GLU A 148
THR A 227
 PXL  A 400 (-3.8A)
None
None
 0.97A 2y7hB-3mbhA:
2.6		 2y7hB-3mbhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 173
TYR A 169
LEU A 166
LEU A 153
 None
 0.94A 3f33A-3mbhA:
undetectable		 3f33A-3mbhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 258
GLU A 267
HIS A  48
 None
 0.80A 3g1uB-3mbhA:
5.5		 3g1uB-3mbhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		4 / 6 VAL A  25
LEU A  40
ILE A 251
ILE A  29
 None
 0.94A 3gcsA-3mbhA:
undetectable		 3gcsA-3mbhA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 171
ILE A 183
THR A 211
 None
 0.70A 3ia4D-3mbhA:
undetectable		 3ia4D-3mbhA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A 132
VAL A  12
LEU A  40
LEU A  85
TRP A  70
 None
 1.38A 4m11A-3mbhA:
undetectable		 4m11A-3mbhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A 132
VAL A  12
LEU A  40
LEU A  85
TRP A  70
 None
 1.35A 4m11C-3mbhA:
1.7		 4m11C-3mbhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A 132
VAL A  12
LEU A  40
LEU A  85
TRP A  70
 None
 1.36A 4m11D-3mbhA:
undetectable		 4m11D-3mbhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 230
THR A 231
THR A 143
LEU A 234
LEU A 107
 None
 1.27A 4pbhA-3mbhA:
undetectable		 4pbhA-3mbhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  89
ILE A  91
GLN A  90
ASP A  61
 None
 0.98A 4w5qA-3mbhA:
3.3		 4w5qA-3mbhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  23
THR A 231
VAL A  37
PHE A  77
 None
 1.02A 4wnvD-3mbhA:
undetectable		 4wnvD-3mbhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 197
THR A 248
ASP A 245
LEU A 244
 None
 1.28A 5m0iB-3mbhA:
undetectable		 5m0iB-3mbhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 226
ASP A 224
LEU A 270
 None
PXL  A 400 (-2.4A)
None
 0.73A 5uhcC-3mbhA:
undetectable		 5uhcC-3mbhA:
12.77