SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 MET A  26
LEU A 284
PHE A 285
VAL A  10
VAL A 251
 None
 1.04A 1hrkA-3mc2A:
undetectable		 1hrkA-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 MET A  26
LEU A 284
PHE A 285
VAL A  10
VAL A 251
 None
 1.08A 1hrkB-3mc2A:
undetectable		 1hrkB-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 GLU A  83
HIS A 249
ASP A 297
 None
 0.81A 1i9gA-3mc2A:
undetectable		 1i9gA-3mc2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.04A 1q23B-3mc2A:
undetectable		 1q23B-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.97A 1q23C-3mc2A:
undetectable		 1q23C-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.98A 1q23E-3mc2A:
undetectable		 1q23E-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 11 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.98A 1q23F-3mc2A:
undetectable		 1q23F-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.96A 1q23H-3mc2A:
undetectable
1q23I-3mc2A:
undetectable		 1q23H-3mc2A:
14.91
1q23I-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 11 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.01A 1q23I-3mc2A:
undetectable		 1q23I-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.06A 1q23K-3mc2A:
undetectable		 1q23K-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 11 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.98A 1q23L-3mc2A:
undetectable		 1q23L-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.96A 1yrcA-3mc2A:
undetectable		 1yrcA-3mc2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.98A 1yrdA-3mc2A:
undetectable		 1yrdA-3mc2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 GLY A 198
THR A 199
ALA A 200
VAL A 205
 None
 0.67A 2a1hA-3mc2A:
undetectable
2a1hB-3mc2A:
undetectable		 2a1hA-3mc2A:
19.43
2a1hB-3mc2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 VAL A 205
GLY A 198
THR A 199
ALA A 200
 None
 0.67A 2a1hA-3mc2A:
undetectable
2a1hB-3mc2A:
undetectable		 2a1hA-3mc2A:
19.43
2a1hB-3mc2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 SER A 626
GLU A 404
ASP A 386
 None
 0.74A 2avdB-3mc2A:
undetectable		 2avdB-3mc2A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 LEU A 582
PRO A 464
GLY A 388
ASP A 386
 None
 0.95A 2ddwB-3mc2A:
undetectable		 2ddwB-3mc2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 ARG A 588
SER A 458
GLY A 460
THR A 453
 None
 1.18A 2f7fA-3mc2A:
undetectable		 2f7fA-3mc2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.97A 2feuA-3mc2A:
undetectable		 2feuA-3mc2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 SER A 117
SER A 152
VAL A 154
LEU A 326
 None
 0.71A 2hdnE-3mc2A:
undetectable
2hdnF-3mc2A:
undetectable
2hdnH-3mc2A:
undetectable		 2hdnE-3mc2A:
4.75
2hdnF-3mc2A:
20.87
2hdnH-3mc2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 SER A 152
VAL A 154
LEU A 326
SER A 117
 None
 0.69A 2hdnF-3mc2A:
undetectable
2hdnG-3mc2A:
undetectable
2hdnH-3mc2A:
undetectable		 2hdnF-3mc2A:
20.87
2hdnG-3mc2A:
4.75
2hdnH-3mc2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 MET A  26
LEU A 284
PHE A 285
VAL A  10
VAL A 251
 None
 1.00A 2hrcA-3mc2A:
undetectable		 2hrcA-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 ILE A 468
LEU A 467
ALA A 583
VAL A 585
PHE A 477
 None
 1.22A 2qo6A-3mc2A:
undetectable		 2qo6A-3mc2A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 SER A 262
ILE A 263
ASP A  58
ARG A   7
 None
 0.95A 2v57A-3mc2A:
undetectable		 2v57A-3mc2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 SER A 262
ILE A 263
ASP A  58
ARG A   7
 None
 0.95A 2v57C-3mc2A:
undetectable		 2v57C-3mc2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 1.06A 2zuhA-3mc2A:
undetectable		 2zuhA-3mc2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.97A 2zuiA-3mc2A:
undetectable		 2zuiA-3mc2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.96A 2zwtA-3mc2A:
undetectable		 2zwtA-3mc2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.96A 2zwuA-3mc2A:
undetectable		 2zwuA-3mc2A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 GLU A  83
THR A 209
ALA A 299
ALA A 298
 None
 0.82A 3ax9B-3mc2A:
undetectable		 3ax9B-3mc2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 SER A 626
GLU A 551
ASP A 630
 None
 0.85A 3bwmA-3mc2A:
undetectable		 3bwmA-3mc2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 SER A 626
GLU A 551
ASP A 630
 None
 0.86A 3bwyA-3mc2A:
undetectable		 3bwyA-3mc2A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 TYR A 657
TYR A 427
GLY A 387
 None
 0.71A 3eteB-3mc2A:
undetectable
3eteD-3mc2A:
undetectable
3eteF-3mc2A:
undetectable		 3eteB-3mc2A:
23.31
3eteD-3mc2A:
23.31
3eteF-3mc2A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.95A 3fwfA-3mc2A:
undetectable		 3fwfA-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.92A 3fwfB-3mc2A:
undetectable		 3fwfB-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.97A 3fwiA-3mc2A:
undetectable		 3fwiA-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.95A 3fwjA-3mc2A:
undetectable		 3fwjA-3mc2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.94A 3l63A-3mc2A:
undetectable		 3l63A-3mc2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		6 / 11 THR A 209
ALA A 298
THR A 296
ALA A 299
ALA A 213
SER A 188
 None
 1.40A 3mg0K-3mc2A:
undetectable
3mg0L-3mc2A:
undetectable		 3mg0K-3mc2A:
16.30
3mg0L-3mc2A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		6 / 12 THR A 209
ALA A 298
THR A 296
ALA A 299
ALA A 213
SER A 188
 None
 1.37A 3mg0Y-3mc2A:
undetectable
3mg0Z-3mc2A:
undetectable		 3mg0Y-3mc2A:
16.30
3mg0Z-3mc2A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 GLU A  83
THR A 209
ALA A 299
ALA A 298
 None
 0.81A 3ns1C-3mc2A:
undetectable		 3ns1C-3mc2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 GLU A  83
THR A 209
ALA A 299
ALA A 298
 None
 0.82A 3ns1L-3mc2A:
undetectable		 3ns1L-3mc2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 THR A 540
ASP A 630
GLU A 625
 None
 0.73A 3qowA-3mc2A:
undetectable		 3qowA-3mc2A:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 7 GLY A 426
PRO A 586
ASN A 587
TYR A 652
GLY A 654
 None
 0.79A 3tajA-3mc2A:
16.4		 3tajA-3mc2A:
34.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 LEU A 320
LEU A 326
GLY A  64
LEU A  66
SER A 125
 None
 1.35A 3tbgA-3mc2A:
undetectable		 3tbgA-3mc2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 LEU A 320
LEU A 326
GLY A  64
LEU A  66
SER A 125
 None
 1.35A 3tbgC-3mc2A:
undetectable		 3tbgC-3mc2A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 5 GLY A 426
PRO A 586
ASN A 587
TYR A 652
 None
 0.83A 3u8qA-3mc2A:
17.1		 3u8qA-3mc2A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 9 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.11A 3u9fA-3mc2A:
0.0		 3u9fA-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.09A 3u9fB-3mc2A:
undetectable
3u9fC-3mc2A:
undetectable		 3u9fB-3mc2A:
14.91
3u9fC-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.06A 3u9fD-3mc2A:
undetectable
3u9fE-3mc2A:
undetectable		 3u9fD-3mc2A:
14.91
3u9fE-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.08A 3u9fE-3mc2A:
undetectable		 3u9fE-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.06A 3u9fG-3mc2A:
undetectable
3u9fH-3mc2A:
undetectable		 3u9fG-3mc2A:
14.91
3u9fH-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.04A 3u9fH-3mc2A:
undetectable
3u9fI-3mc2A:
undetectable		 3u9fH-3mc2A:
14.91
3u9fI-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.01A 3u9fI-3mc2A:
undetectable		 3u9fI-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.05A 3u9fJ-3mc2A:
undetectable
3u9fK-3mc2A:
undetectable		 3u9fJ-3mc2A:
14.91
3u9fK-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.08A 3u9fK-3mc2A:
undetectable		 3u9fK-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 11 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.05A 3u9fN-3mc2A:
undetectable
3u9fO-3mc2A:
undetectable		 3u9fN-3mc2A:
14.91
3u9fO-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 9 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.03A 3u9fP-3mc2A:
undetectable		 3u9fP-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.02A 3u9fP-3mc2A:
undetectable
3u9fS-3mc2A:
undetectable		 3u9fP-3mc2A:
14.91
3u9fS-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.95A 3wrjA-3mc2A:
undetectable		 3wrjA-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 5 PHE A 186
LEU A  66
GLY A 123
VAL A 154
 None
 0.77A 3wrkA-3mc2A:
undetectable		 3wrkA-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 5 PHE A 186
LEU A  66
GLY A 123
VAL A 154
 None
 0.78A 3wrkD-3mc2A:
undetectable		 3wrkD-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.97A 3wrlA-3mc2A:
undetectable		 3wrlA-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.92A 3wrlE-3mc2A:
undetectable		 3wrlE-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.94A 3wrmA-3mc2A:
undetectable		 3wrmA-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 THR A 375
LEU A 398
VAL A 399
VAL A 600
 None
 0.96A 3wrmF-3mc2A:
undetectable		 3wrmF-3mc2A:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 GLY A 426
PRO A 586
GLY A 654
TYR A 657
 None
 0.60A 4dxuA-3mc2A:
17.0		 4dxuA-3mc2A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 VAL A  67
ILE A  49
SER A  76
ALA A  54
 None
 0.96A 4eyzA-3mc2A:
undetectable		 4eyzA-3mc2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 8 VAL A  67
ILE A  49
SER A  76
ALA A  54
 None
 0.97A 4eyzB-3mc2A:
undetectable		 4eyzB-3mc2A:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 9 GLY A 426
PRO A 586
TYR A 652
GLY A 654
TYR A 657
 None
 0.49A 4fimA-3mc2A:
16.4		 4fimA-3mc2A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 6 GLY A 426
PRO A 586
ASN A 587
TYR A 652
GLY A 654
 None
 0.77A 4fjpA-3mc2A:
17.1		 4fjpA-3mc2A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 GLY A 426
PRO A 586
TYR A 652
GLY A 654
 None
 0.36A 4forA-3mc2A:
15.6		 4forA-3mc2A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 PRO A 586
TYR A 652
GLY A 654
 None
 0.23A 4g2zA-3mc2A:
38.8		 4g2zA-3mc2A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 LEU A 467
HIS A 581
ALA A 583
TYR A 657
 None
 0.52A 4g77A-3mc2A:
38.6		 4g77A-3mc2A:
34.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 9 VAL A 533
ALA A 534
GLY A 447
SER A 484
GLY A 531
 None
 1.25A 4mmfA-3mc2A:
undetectable		 4mmfA-3mc2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 9 VAL A 533
ALA A 534
GLY A 447
SER A 484
GLY A 531
 None
 1.27A 4mmfB-3mc2A:
undetectable		 4mmfB-3mc2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 GLU A 345
ILE A 372
ALA A 363
 None
 0.59A 4wnwB-3mc2A:
undetectable		 4wnwB-3mc2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 SER A 626
GLU A 551
ASP A 630
 None
 0.83A 4xudA-3mc2A:
undetectable		 4xudA-3mc2A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 GLU A  83
HIS A 249
ASP A 297
 None
 0.78A 5c0oG-3mc2A:
undetectable		 5c0oG-3mc2A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 GLU A 224
PHE A 149
PHE A 204
THR A 134
LEU A 109
 None
 1.24A 5esgA-3mc2A:
undetectable		 5esgA-3mc2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 THR A 540
ASP A 630
GLU A 625
 None
 0.66A 5fa8A-3mc2A:
undetectable		 5fa8A-3mc2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		3 / 3 THR A 296
ASP A 297
ALA A 298
 None
 0.07A 5g5gB-3mc2A:
undetectable		 5g5gB-3mc2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 VAL A 585
ALA A 583
VAL A 429
TYR A 428
 None
 1.06A 5i8fA-3mc2A:
undetectable		 5i8fA-3mc2A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 HIS A 249
THR A  93
SER A  87
GLY A  86
ALA A 299
 None
 1.34A 5l5zV-3mc2A:
undetectable
5l5zb-3mc2A:
undetectable		 5l5zV-3mc2A:
16.91
5l5zb-3mc2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 HIS A 249
THR A  93
SER A  87
GLY A  86
ALA A 299
 None
 1.32A 5l5zH-3mc2A:
undetectable
5l5zN-3mc2A:
undetectable		 5l5zH-3mc2A:
16.91
5l5zN-3mc2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 ILE A   6
VAL A  40
VAL A  10
ILE A  80
VAL A 251
 None
 1.18A 5n0sB-3mc2A:
undetectable		 5n0sB-3mc2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 LEU A 385
PRO A 368
GLY A 388
GLY A 456
ALA A 393
 None
 1.18A 5o96E-3mc2A:
undetectable
5o96F-3mc2A:
undetectable		 5o96E-3mc2A:
16.38
5o96F-3mc2A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 VAL A 305
VAL A 250
PRO A 247
ALA A  82
 None
 0.67A 5ospA-3mc2A:
undetectable		 5ospA-3mc2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 7 VAL A 305
VAL A 250
PRO A 247
ALA A  82
 None
 0.65A 5osrA-3mc2A:
undetectable		 5osrA-3mc2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 10 GLY A 460
VAL A 429
TYR A 427
ASN A 462
TYR A 657
 None
 1.47A 5tqrB-3mc2A:
undetectable		 5tqrB-3mc2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		5 / 12 ARG A 588
PHE A 389
LEU A 398
GLY A 394
MET A 376
 None
 0.85A 5x66A-3mc2A:
undetectable
5x66B-3mc2A:
undetectable		 5x66A-3mc2A:
17.69
5x66B-3mc2A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3mc2 INHIBITOR OF
CARBONIC ANHYDRASE
(Mus
musculus) 		4 / 6 SER A 592
ARG A 346
ASP A 350
ASP A 381
 None
 1.23A 5zw4A-3mc2A:
undetectable		 5zw4A-3mc2A:
14.56