SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RLB_E_REAE176_1 (RETINOL BINDING PROTEIN)	3mc3	DSRE/DSRF-LIKE FAMILY PROTEIN (Sulfolobus solfataricus)	5 / 10	LEU A 60 ALA A 38 VAL A 108 ASP A 81 PHE A 76	None	1.28A	1rlbE-3mc3A: undetectable	1rlbE-3mc3A: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DTU_C_DXCC576_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2)	3mc3	DSRE/DSRF-LIKE FAMILY PROTEIN (Sulfolobus solfataricus)	4 / 8	PRO A 34 ALA A 38 ILE A 19 HIS A 23	None None None CL A 134 (-4.5A)	0.87A	3dtuC-3mc3A: undetectable 3dtuD-3mc3A: undetectable	3dtuC-3mc3A: 12.72 3dtuD-3mc3A: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JWQ_A_VIAA901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA)	3mc3	DSRE/DSRF-LIKE FAMILY PROTEIN (Sulfolobus solfataricus)	5 / 9	LEU A 35 VAL A 109 LEU A 114 PHE A 52 VAL A 21	None MLY A 62 ( 4.2A) None None None	1.22A	3jwqA-3mc3A: undetectable	3jwqA-3mc3A: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOU_A_C04A207_1 (UNCHARACTERIZED PROTEIN)	3mc3	DSRE/DSRF-LIKE FAMILY PROTEIN (Sulfolobus solfataricus)	3 / 3	GLY A 87 GLU A 47 THR A 48	MLY A 84 ( 3.6A) MLY A 16 ( 3.4A) None	0.52A	4kouA-3mc3A: undetectable	4kouA-3mc3A: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GBF_A_ACTA507_0 (MOLYBDOPTERIN BIOSYNTHESIS PROTEIN CNX1)	3mc3	DSRE/DSRF-LIKE FAMILY PROTEIN (Sulfolobus solfataricus)	3 / 3	LYS A 85 SER A 43 SER A 39	MLY A 84 ( 2.9A) None None	0.79A	6gbfA-3mc3A: undetectable	6gbfA-3mc3A: 14.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RLB_E_REAE176_1","RETINOL BINDING PROTEIN","3mc3","DSRE\/DSRF-LIKE FAMILY PROTEIN","Sulfolobus solfataricus",5,"LEU A  60;ALA A  38;VAL A 108;ASP A  81;PHE A  76","None","1.28A","1rlbE-3mc3A:undetectable","1rlbE-3mc3A:18.02"],["3DTU_C_DXCC576_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 2","3mc3","DSRE\/DSRF-LIKE FAMILY PROTEIN","Sulfolobus solfataricus",4,"PRO A  34;ALA A  38;ILE A  19;HIS A  23","None;None;None; CL A 134 (-4.5A)","0.87A","3dtuC-3mc3A:undetectable;3dtuD-3mc3A:undetectable","3dtuC-3mc3A:12.72;3dtuD-3mc3A:20.55"],["3JWQ_A_VIAA901_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA","3mc3","DSRE\/DSRF-LIKE FAMILY PROTEIN","Sulfolobus solfataricus",5,"LEU A  35;VAL A 109;LEU A 114;PHE A  52;VAL A  21","None;MLY A  62 ( 4.2A);None;None;None","1.22A","3jwqA-3mc3A:undetectable","3jwqA-3mc3A:16.92"],["4KOU_A_C04A207_1","UNCHARACTERIZED PROTEIN","3mc3","DSRE\/DSRF-LIKE FAMILY PROTEIN","Sulfolobus solfataricus",3,"GLY A  87;GLU A  47;THR A  48","MLY A  84 ( 3.6A);MLY A  16 ( 3.4A);None","0.52A","4kouA-3mc3A:undetectable","4kouA-3mc3A:21.08"],["6GBF_A_ACTA507_0","MOLYBDOPTERIN BIOSYNTHESIS PROTEIN CNX1","3mc3","DSRE\/DSRF-LIKE FAMILY PROTEIN","Sulfolobus solfataricus",3,"LYS A  85;SER A  43;SER A  39","MLY A  84 ( 2.9A);None;None","0.79A","6gbfA-3mc3A:undetectable","6gbfA-3mc3A:14.19"]]