SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 271
LEU C 310
ALA C 263
ALA C 267
VAL C 294
 None
 1.25A 1cbrA-3mc6C:
undetectable		 1cbrA-3mc6C:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 271
LEU C 310
ALA C 263
ALA C 267
VAL C 294
 None
 1.25A 1cbrB-3mc6C:
undetectable		 1cbrB-3mc6C:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 HIS C 379
VAL C 216
MET C 219
SER C 351
 PO4  C   1 (-4.2A)
None
None
None
 1.13A 1kb9A-3mc6C:
undetectable
1kb9C-3mc6C:
undetectable
1kb9D-3mc6C:
undetectable
1kb9E-3mc6C:
undetectable		 1kb9A-3mc6C:
22.26
1kb9C-3mc6C:
22.59
1kb9D-3mc6C:
17.40
1kb9E-3mc6C:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 488
SER C 539
LEU C 486
ASN C 487
 None
 1.20A 1y0xX-3mc6C:
undetectable		 1y0xX-3mc6C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 481
SER C 170
HIS C 512
ALA C 504
ASN C 503
 None
 1.44A 2gl0D-3mc6C:
undetectable
2gl0E-3mc6C:
undetectable		 2gl0D-3mc6C:
16.53
2gl0E-3mc6C:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 SER C 343
ILE C 374
ASP C 365
ARG C 367
 None
 1.03A 2v57A-3mc6C:
undetectable		 2v57A-3mc6C:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 SER C 343
ILE C 374
TYR C 476
ASP C 365
 None
 1.01A 2v57A-3mc6C:
undetectable		 2v57A-3mc6C:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 SER C 343
ILE C 374
ASP C 365
ARG C 367
 None
 1.02A 2v57C-3mc6C:
undetectable		 2v57C-3mc6C:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 SER C 343
ILE C 374
TYR C 476
ASP C 365
 None
 1.01A 2v57C-3mc6C:
undetectable		 2v57C-3mc6C:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 529
LEU C 491
ILE C 488
PHE C 457
ILE C 470
 None
 1.07A 3b2rA-3mc6C:
undetectable		 3b2rA-3mc6C:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 THR C 266
LEU C 287
VAL C 299
GLY C 297
ILE C 325
 None
 1.11A 3ijdA-3mc6C:
undetectable		 3ijdA-3mc6C:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 THR C 372
LEU C 398
ALA C 242
SER C 245
 None
 1.01A 3kp6A-3mc6C:
undetectable		 3kp6A-3mc6C:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU C 282
PHE C 271
PRO C 264
ALA C 267
 None
 1.45A 3vm4A-3mc6C:
undetectable		 3vm4A-3mc6C:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP C 342
SER C 343
MET C 392
GLY C 235
 None
None
None
PO4  C   1 (-3.1A)
 0.98A 4af0A-3mc6C:
undetectable		 4af0A-3mc6C:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 495
GLU C 490
VAL C 509
ALA C 510
 None
 0.87A 4nkvC-3mc6C:
undetectable		 4nkvC-3mc6C:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 495
GLU C 490
VAL C 509
ALA C 510
 None
 0.90A 4nkxA-3mc6C:
undetectable		 4nkxA-3mc6C:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 475
GLU C 354
TYR C 476
 None
 0.96A 4r29D-3mc6C:
undetectable		 4r29D-3mc6C:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 173
TRP C 164
GLN C 184
THR C 185
ILE C 427
 None
 1.37A 4s0vA-3mc6C:
undetectable		 4s0vA-3mc6C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY C 370
LEU C 339
ASP C 324
VAL C 341
VAL C 299
 None
 1.08A 4wnwA-3mc6C:
undetectable		 4wnwA-3mc6C:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE C 366
SER C 343
MET C 392
LEU C 364
 None
 1.46A 5dzka-3mc6C:
undetectable
5dzko-3mc6C:
undetectable		 5dzka-3mc6C:
19.55
5dzko-3mc6C:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU C 491
LEU C 511
SER C 483
ALA C 510
 None
 0.74A 5uunA-3mc6C:
undetectable		 5uunA-3mc6C:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG C 517
GLY C 176
THR C 516
VAL C 173
 None
 1.17A 5ysiA-3mc6C:
undetectable		 5ysiA-3mc6C:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 345
ASP C 365
ILE C 325
 None
 0.63A 6dh0B-3mc6C:
undetectable		 6dh0B-3mc6C:
11.09