SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe)
3 / 3 LEU A 517
SER A 579
ASN B 254
None
0.76A 1bx4A-3mcaA:
undetectable
1bx4A-3mcaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A 262
LEU A 180
VAL A 360
ILE A 362
LEU A 370
None
0.99A 1fm6U-3mcaA:
undetectable
1fm6U-3mcaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
4 / 7 GLU B  22
LEU B 106
GLU B 136
MET B 156
None
1.10A 1linA-3mcaB:
undetectable
1linA-3mcaB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
4 / 5 ALA B 225
TYR B 220
ILE B 221
ASP B 187
None
1.10A 1upfA-3mcaB:
undetectable
1upfA-3mcaB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
4 / 5 ALA B 225
TYR B 220
ILE B 221
ASP B 187
None
0.96A 1upfC-3mcaB:
undetectable
1upfC-3mcaB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
3 / 3 GLY B 353
GLU B 274
ASP B 357
None
0.65A 2b25B-3mcaB:
undetectable
2b25B-3mcaB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 SER A 164
LEU A 405
LEU A 469
LEU A 471
None
0.98A 2bfpA-3mcaA:
undetectable
2bfpA-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 SER A 164
LEU A 405
LEU A 469
LEU A 471
None
0.92A 2bfpC-3mcaA:
undetectable
2bfpC-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 SER A 441
LEU A 471
LEU A 407
LEU A 405
None
0.99A 2bfpC-3mcaA:
undetectable
2bfpC-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 SER A 164
LEU A 405
LEU A 469
LEU A 471
None
0.89A 2bfpD-3mcaA:
undetectable
2bfpD-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 5 LEU A 571
ILE A 484
LEU A 485
SER A 486
None
0.93A 2byoA-3mcaA:
undetectable
2byoA-3mcaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 4 VAL A 283
LEU A 387
ILE A 197
LEU A 194
None
0.98A 2byoA-3mcaA:
undetectable
2byoA-3mcaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A 262
VAL A 182
ASP A 287
SER A 270
ILE A 197
None
1.17A 2dcfA-3mcaA:
undetectable
2dcfA-3mcaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 10 ILE A 587
ALA A 565
ILE A 553
GLU A 501
ILE A 502
None
1.23A 2dm6A-3mcaA:
undetectable
2dm6B-3mcaA:
undetectable
2dm6A-3mcaA:
19.17
2dm6B-3mcaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
3 / 3 SER B 360
HIS A 542
ASP B 288
None
0.81A 2oxtA-3mcaB:
undetectable
2oxtA-3mcaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 10 PHE A 555
ILE A 543
PHE A 574
LEU A 564
ILE A 507
None
1.33A 2v0mA-3mcaA:
undetectable
2v0mA-3mcaA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 9 ALA B 302
VAL B 299
LEU B 366
LEU B 311
ALA B 364
None
0.75A 2z0yA-3mcaB:
undetectable
2z0yA-3mcaB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 9 ALA B 302
VAL B 299
LEU B 366
LEU B 311
ALA B 364
None
0.80A 2z0yB-3mcaB:
undetectable
2z0yB-3mcaB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A 262
VAL A 182
ASP A 287
SER A 270
ILE A 197
None
1.16A 3a65A-3mcaA:
undetectable
3a65A-3mcaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 12 ALA B 139
TYR B 271
VAL B 272
GLY B 138
ILE B 137
None
1.49A 3a65A-3mcaB:
undetectable
3a65A-3mcaB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ASP A 392
SER A 321
ILE A 362
PRO A 361
ILE A 197
None
1.20A 3clbB-3mcaA:
undetectable
3clbB-3mcaA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
3 / 3 SER B 188
GLN B 191
PHE B 190
None
0.68A 3g4lC-3mcaB:
undetectable
3g4lC-3mcaB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 SER A 441
ASP A 483
ASP A 444
None
0.74A 3iv6A-3mcaA:
undetectable
3iv6A-3mcaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 SER A 441
ASP A 483
ASP A 444
None
0.76A 3iv6C-3mcaA:
undetectable
3iv6C-3mcaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 PHE A 345
VAL A 342
ILE A 318
VAL A 320
VAL A 322
None
1.21A 3iw1A-3mcaA:
undetectable
3iw1A-3mcaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe)
4 / 8 ASP A 483
SER A 440
PHE A 560
LEU B 146
None
0.99A 3m0wE-3mcaA:
undetectable
3m0wF-3mcaA:
undetectable
3m0wG-3mcaA:
undetectable
3m0wH-3mcaA:
undetectable
3m0wE-3mcaA:
10.53
3m0wF-3mcaA:
10.53
3m0wG-3mcaA:
10.53
3m0wH-3mcaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 12 HIS B 350
LEU B 266
ILE B 152
GLY B 138
ALA B 139
None
1.02A 3n8xB-3mcaB:
undetectable
3n8xB-3mcaB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 12 LEU B 266
LEU B 202
ILE B 152
GLY B 138
ALA B 139
None
0.89A 3n8zB-3mcaB:
undetectable
3n8zB-3mcaB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 11 SER B 314
ILE B 362
VAL B 299
PHE B 303
ILE B 308
None
1.17A 3rf4A-3mcaB:
undetectable
3rf4C-3mcaB:
undetectable
3rf4A-3mcaB:
15.94
3rf4C-3mcaB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 11 ILE B 308
SER B 314
ILE B 362
VAL B 299
PHE B 303
None
1.19A 3rf4A-3mcaB:
undetectable
3rf4B-3mcaB:
undetectable
3rf4A-3mcaB:
15.94
3rf4B-3mcaB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 11 ILE B 308
SER B 314
ILE B 362
VAL B 299
PHE B 303
None
1.22A 3rf4B-3mcaB:
undetectable
3rf4C-3mcaB:
undetectable
3rf4B-3mcaB:
15.94
3rf4C-3mcaB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 5 HIS B 251
GLU B 255
ARG A 577
HIS B 244
None
1.38A 4hvcB-3mcaB:
undetectable
4hvcB-3mcaB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe)
4 / 5 ILE A 451
ARG B 171
ASP A 410
VAL A 430
None
1.19A 4nkxC-3mcaA:
undetectable
4nkxC-3mcaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe)
4 / 5 ILE A 451
ARG B 171
ASP A 410
VAL A 430
None
1.21A 4nkxD-3mcaA:
undetectable
4nkxD-3mcaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
4 / 6 ASP B 357
ASP B 315
ASN B  31
ARG B 319
None
1.14A 4ntxA-3mcaB:
undetectable
4ntxC-3mcaB:
undetectable
4ntxA-3mcaB:
22.25
4ntxC-3mcaB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
6 / 12 ILE A 273
VAL A 283
LEU A 284
LEU A 313
LEU A 310
LEU A 309
None
1.44A 4o1zA-3mcaA:
undetectable
4o1zA-3mcaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 12 THR B 157
ILE B 250
ILE B 256
ALA B 208
ILE B 152
None
0.97A 4rp8C-3mcaB:
undetectable
4rp8C-3mcaB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
5 / 12 LEU B 243
LEU B 257
ALA B 139
VAL B 141
ALA B 208
None
0.99A 4x1iB-3mcaB:
undetectable
4x1iB-3mcaB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 LEU A 378
TYR A 379
TRP A 330
SER A 363
SER A 331
None
1.42A 4yvxA-3mcaA:
undetectable
4yvxA-3mcaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 10 ASP A 392
LEU A 201
LEU A 370
GLY A 195
MET A 198
None
1.45A 4zp0A-3mcaA:
undetectable
4zp0A-3mcaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 LEU A 576
PHE A 505
ILE A 575
None
0.47A 5dzk1-3mcaA:
undetectable
5dzkF-3mcaA:
undetectable
5dzkM-3mcaA:
undetectable
5dzk1-3mcaA:
4.35
5dzkF-3mcaA:
15.71
5dzkM-3mcaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 4 ALA A 427
PRO A 396
LEU A 180
HIS A 179
None
1.19A 5eskA-3mcaA:
undetectable
5eskA-3mcaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 LEU A 346
PHE A 352
LEU A 394
THR A 183
LEU A 387
None
1.19A 5iepA-3mcaA:
undetectable
5iepA-3mcaA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 6 HIS A 358
VAL A 360
TYR A 382
GLN A 393
None
1.42A 5kkzA-3mcaA:
undetectable
5kkzG-3mcaA:
undetectable
5kkzA-3mcaA:
21.10
5kkzG-3mcaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
4 / 5 ALA B 147
VAL B 140
PHE B 185
ILE B 193
None
1.04A 5of1A-3mcaB:
undetectable
5of1A-3mcaB:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 GLY A 428
ARG A 452
VAL A 425
ASP A 465
None
1.00A 5vlmA-3mcaA:
undetectable
5vlmA-3mcaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 VAL A 286
VAL A 181
GLY A 301
PHE A 293
GLY A 189
None
1.06A 6brdC-3mcaA:
undetectable
6brdC-3mcaA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 LEU A 521
GLY A 522
LEU A 436
ILE A 409
ASP A 410
None
1.14A 6bxmA-3mcaA:
2.7
6bxmA-3mcaA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 12 ASP B 357
ALA B 363
GLY A 514
SER A 554
ASP B 378
None
1.30A 6clxA-3mcaB:
undetectable
6clxA-3mcaB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)
3mca PROTEIN DOM34
(Schizosaccharomy
ces
pombe)
3 / 3 TYR B 282
ALA B 363
LEU B 359
None
0.75A 6d9kF-3mcaB:
5.3
6d9kF-3mcaB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 PHE A 505
ARG A 546
GLN A 503
None
0.87A 6g1pB-3mcaA:
undetectable
6g1pB-3mcaA:
19.44