SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mcf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 6 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.00A 1ictB-3mcfA:
undetectable		 1ictB-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 6 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.00A 3cfqA-3mcfA:
undetectable		 3cfqA-3mcfA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		3 / 3 ARG A  44
HIS A 132
TYR A  41
 None
 1.34A 4fu9A-3mcfA:
undetectable		 4fu9A-3mcfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 6 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.00A 4i89A-3mcfA:
undetectable		 4i89A-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 6 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.01A 5bojA-3mcfA:
undetectable		 5bojA-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 5 SER A  39
GLY A  51
GLU A  53
ARG A 115
 FLC  A   0 (-3.0A)
None
None
FLC  A   0 (-3.1A)
 1.04A 5cdqA-3mcfA:
undetectable
5cdqB-3mcfA:
undetectable
5cdqC-3mcfA:
undetectable		 5cdqA-3mcfA:
14.14
5cdqB-3mcfA:
22.80
5cdqC-3mcfA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		5 / 9 ARG A 115
SER A  38
ALA A  21
VAL A  47
GLU A  69
 FLC  A   0 (-3.1A)
FLC  A   0 (-3.2A)
None
None
FLC  A   0 ( 4.7A)
 1.20A 5i3cA-3mcfA:
undetectable		 5i3cA-3mcfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 6 LEU A  23
ALA A  21
LEU A  80
THR A  93
 None
 1.00A 5l4iA-3mcfA:
undetectable		 5l4iA-3mcfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens) 		4 / 6 LEU A  35
VAL A  33
LEU A  23
VAL A 122
 None
 0.87A 5x7zA-3mcfA:
undetectable		 5x7zA-3mcfA:
24.56