SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3mcr NADH DEHYDROGENASE,
SUBUNIT C
(Thermobifida
fusca) 		3 / 3 ASP A 127
ARG A 123
ILE A  90
 None
 0.85A 1a4gB-3mcrA:
undetectable		 1a4gB-3mcrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3mcr NADH DEHYDROGENASE,
SUBUNIT C
(Thermobifida
fusca) 		3 / 3 THR A 109
VAL A 102
GLU A 107
 None
 0.69A 3v4tA-3mcrA:
undetectable
3v4tD-3mcrA:
undetectable		 3v4tA-3mcrA:
20.75
3v4tD-3mcrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3mcr NADH DEHYDROGENASE,
SUBUNIT C
(Thermobifida
fusca) 		4 / 5 GLU A 147
GLU A 145
TYR A 143
GLU A 150
 None
 1.23A 4r87E-3mcrA:
undetectable		 4r87E-3mcrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3mcr NADH DEHYDROGENASE,
SUBUNIT C
(Thermobifida
fusca) 		4 / 7 GLU A 147
GLU A 145
TYR A 143
GLU A 150
 None
 1.24A 4r87I-3mcrA:
undetectable		 4r87I-3mcrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 3mcr NADH DEHYDROGENASE,
SUBUNIT C
(Thermobifida
fusca) 		4 / 5 SER A 184
VAL A 183
ASN A 189
PRO A 180
 None
 1.25A 6fi4A-3mcrA:
undetectable
6fi4B-3mcrA:
undetectable		 6fi4A-3mcrA:
21.40
6fi4B-3mcrA:
4.35