SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3mcs PUTATIVE
MONOOXYGENASE
(Fusobacterium
nucleatum) 		5 / 12 ILE A 133
THR A 189
ILE A 193
ILE A 186
THR A 140
 None
 0.88A 3clbC-3mcsA:
undetectable		 3clbC-3mcsA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mcs PUTATIVE
MONOOXYGENASE
(Fusobacterium
nucleatum) 		5 / 6 LEU A   7
TYR A 150
VAL A  98
LEU A  41
ASP A 213
 None
 1.49A 3cs9D-3mcsA:
undetectable		 3cs9D-3mcsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3mcs PUTATIVE
MONOOXYGENASE
(Fusobacterium
nucleatum) 		6 / 12 LEU A 147
GLY A 211
ASP A 213
ILE A 100
ILE A  60
VAL A 166
 None
 1.49A 3k4vA-3mcsA:
undetectable		 3k4vA-3mcsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3mcs PUTATIVE
MONOOXYGENASE
(Fusobacterium
nucleatum) 		4 / 7 ALA A  45
SER A  55
VAL A  14
LEU A 204
 None
 0.87A 3o14A-3mcsA:
undetectable		 3o14A-3mcsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3mcs PUTATIVE
MONOOXYGENASE
(Fusobacterium
nucleatum) 		4 / 7 ALA A  25
THR A  26
TYR A  29
VAL A  82
 None
 0.71A 6cduA-3mcsA:
undetectable
6cduE-3mcsA:
undetectable		 6cduA-3mcsA:
21.45
6cduE-3mcsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3mcs PUTATIVE
MONOOXYGENASE
(Fusobacterium
nucleatum) 		4 / 8 VAL A  82
ALA A  25
THR A  26
TYR A  29
 None
 0.67A 6cduD-3mcsA:
undetectable
6cduE-3mcsA:
undetectable		 6cduD-3mcsA:
21.45
6cduE-3mcsA:
21.45