SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 12 HIS A  75
GLY A  71
VAL A  62
GLN A  93
ARG A  58
 None
 1.14A 1n2xA-3mcwA:
3.9		 1n2xA-3mcwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 9 LEU A 142
ASN A  32
HIS A 166
GLU A 144
HIS A  33
 None
 1.50A 2bnnA-3mcwA:
0.4
2bnnB-3mcwA:
0.0		 2bnnA-3mcwA:
25.23
2bnnB-3mcwA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		4 / 8 ASN A  32
HIS A  33
GLU A 144
HIS A 166
 None
 0.98A 2bnnA-3mcwA:
undetectable
2bnnB-3mcwA:
undetectable		 2bnnA-3mcwA:
25.23
2bnnB-3mcwA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		3 / 3 TRP A  47
ALA A 118
VAL A 116
 None
 0.72A 2izqA-3mcwA:
undetectable
2izqB-3mcwA:
undetectable		 2izqA-3mcwA:
6.72
2izqB-3mcwA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		4 / 6 ASP A 185
ILE A 186
LEU A  43
GLU A 144
 None
 1.07A 2ya7B-3mcwA:
undetectable		 2ya7B-3mcwA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		4 / 5 ALA A  39
GLY A 119
CYH A 147
HIS A  33
 None
 1.47A 2yldA-3mcwA:
undetectable		 2yldA-3mcwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		4 / 5 ALA A  39
GLY A 119
CYH A 147
HIS A  33
 None
 1.42A 2ylgA-3mcwA:
undetectable		 2ylgA-3mcwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		3 / 3 ALA A 118
VAL A 116
TRP A  47
 None
 0.71A 3l8lA-3mcwA:
undetectable
3l8lB-3mcwA:
undetectable		 3l8lA-3mcwA:
6.72
3l8lB-3mcwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		3 / 3 ALA A 118
VAL A 116
TRP A  47
 None
 0.69A 3l8lC-3mcwA:
undetectable
3l8lD-3mcwA:
undetectable		 3l8lC-3mcwA:
6.72
3l8lD-3mcwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 9 THR A 129
ALA A  97
ILE A  57
HIS A  59
ASN A 124
 None
None
None
None
EDO  A 204 (-4.0A)
 1.46A 3upwA-3mcwA:
undetectable		 3upwA-3mcwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		4 / 5 ALA A  39
GLY A 119
CYH A 147
HIS A  33
 None
 1.47A 3zwiA-3mcwA:
undetectable		 3zwiA-3mcwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 11 THR A 129
ALA A 133
LEU A 115
PHE A 138
SER A  96
 None
 1.46A 4claA-3mcwA:
undetectable		 4claA-3mcwA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 11 ILE A  17
GLU A  37
GLY A  74
HIS A  59
TYR A  68
 None
None
None
None
EDO  A 204 (-4.5A)
 1.13A 4e47A-3mcwA:
undetectable		 4e47A-3mcwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 11 ILE A  17
GLU A  37
GLY A  74
HIS A  59
TYR A  68
 None
None
None
None
EDO  A 204 (-4.5A)
 1.18A 4jdsA-3mcwA:
undetectable		 4jdsA-3mcwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		5 / 9 HIS A 166
LEU A 142
GLY A 146
VAL A 126
SER A 121
 None
None
None
None
EDO  A 204 (-3.6A)
 1.05A 4qd3A-3mcwA:
undetectable		 4qd3A-3mcwA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 3mcw PUTATIVE HYDROLASE
(Chromobacterium
violaceum) 		4 / 5 ALA A  39
GLY A 119
CYH A 147
HIS A  33
 None
 1.42A 5jt4A-3mcwA:
undetectable		 5jt4A-3mcwA:
20.87