SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 PHE A 358
PRO A 359
ASP A  70
TYR A 300
LEU A 434
 None
 1.45A 1e7wB-3mcxA:
undetectable		 1e7wB-3mcxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 233
LEU A 427
LEU A 388
GLY A 387
 None
 0.83A 1n13D-3mcxA:
undetectable
1n13E-3mcxA:
undetectable		 1n13D-3mcxA:
13.39
1n13E-3mcxA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 459
TYR A  92
ARG A 453
THR A 461
 None
 1.43A 1nw3A-3mcxA:
0.7		 1nw3A-3mcxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 233
LEU A 227
ALA A 226
LEU A 277
LEU A 434
 None
 1.19A 1s9pB-3mcxA:
undetectable		 1s9pB-3mcxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 446
ILE A 426
ALA A 384
ALA A 241
 None
 0.82A 1w0gA-3mcxA:
undetectable		 1w0gA-3mcxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.82A 1wmqA-3mcxA:
undetectable		 1wmqA-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.83A 1wmqB-3mcxA:
undetectable		 1wmqB-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.82A 1wpuA-3mcxA:
undetectable		 1wpuA-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.81A 1wpuB-3mcxA:
undetectable		 1wpuB-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.87A 1wrqA-3mcxA:
undetectable		 1wrqA-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A  87
GLY A 295
ALA A 296
HIS A  58
 GOL  A  12 (-2.6A)
None
None
None
 0.85A 1wrqB-3mcxA:
undetectable		 1wrqB-3mcxA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 278
ILE A  51
ASN A  49
GLN A  45
 None
 0.81A 2a8tB-3mcxA:
undetectable		 2a8tB-3mcxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 423
LEU A 427
ILE A 426
ASN A 234
LEU A 233
 None
 0.91A 2bdmA-3mcxA:
0.6		 2bdmA-3mcxA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 363
PHE A 358
GLY A 269
ASN A 370
PRO A 297
 None
 1.01A 2dpmA-3mcxA:
undetectable		 2dpmA-3mcxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 280
ASP A 271
THR A 291
GLY A 290
GLY A 289
 None
 1.18A 2uvnA-3mcxA:
undetectable		 2uvnA-3mcxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 112
GLU A 485
ASN A 491
 GOL  A  10 (-3.4A)
GOL  A  10 (-2.5A)
None
 1.03A 2y7hC-3mcxA:
undetectable		 2y7hC-3mcxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A 103
GLY A  69
TYR A  68
ASP A 316
TYR A  92
 None
 1.48A 3a27A-3mcxA:
undetectable		 3a27A-3mcxA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 357
ARG A 375
ASP A 327
 None
 1.36A 3o7wA-3mcxA:
undetectable		 3o7wA-3mcxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A  52
LEU A 227
PHE A 278
TYR A  60
 None
 1.31A 3po7A-3mcxA:
undetectable		 3po7A-3mcxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 VAL A 199
VAL A 174
ILE A 115
ARG A 230
 None
 0.95A 3pyyA-3mcxA:
undetectable		 3pyyA-3mcxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  67
TYR A  91
LEU A 159
TYR A 442
 None
 1.04A 4b3qA-3mcxA:
undetectable		 4b3qA-3mcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 151
TYR A  60
VAL A 114
ILE A  51
LEU A  48
 None
 1.43A 4lhmA-3mcxA:
undetectable		 4lhmA-3mcxA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 290
ILE A 371
ASN A 370
GLY A  62
SER A 288
 None
 1.24A 4obwC-3mcxA:
undetectable		 4obwC-3mcxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 189
GLY A 161
SER A 171
LEU A 172
 None
 1.26A 5bphA-3mcxA:
undetectable		 5bphA-3mcxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 189
GLY A 161
SER A 171
LEU A 172
 None
 1.03A 5bphB-3mcxA:
undetectable		 5bphB-3mcxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 189
GLY A 161
SER A 171
LEU A 172
 None
 1.07A 5bphD-3mcxA:
undetectable		 5bphD-3mcxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 4 ASP A 474
ILE A 477
ARG A  72
ARG A 476
 None
 1.32A 5m67C-3mcxA:
0.0		 5m67C-3mcxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A 219
ALA A 224
LEU A 227
ILE A 374
 None
 0.74A 5mvmB-3mcxA:
2.2
5mvmC-3mcxA:
2.2		 5mvmB-3mcxA:
10.62
5mvmC-3mcxA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 THR A 135
ASN A 139
ILE A 125
GLU A 126
 None
 1.27A 5uigA-3mcxA:
2.7		 5uigA-3mcxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 177
TRP A 108
ILE A 492
PRO A 175
 GOL  A  10 (-4.4A)
GOL  A  10 (-4.1A)
None
GOL  A  10 (-4.4A)
 1.12A 6a4iA-3mcxA:
1.8		 6a4iA-3mcxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 7 GLY A  57
GLY A  62
GLY A 295
GLY A 293
GLY A 292
 None
 0.91A 6ag0A-3mcxA:
undetectable		 6ag0A-3mcxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3mcx SUSD SUPERFAMILY
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 438
GLY A 436
ASP A  70
VAL A  76
ASP A 443
 None
 1.19A 6i5zD-3mcxA:
undetectable		 6i5zD-3mcxA:
23.65