SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 7 LEU A 313
HIS A 256
THR A  13
TYR A 338
 None
 1.22A 1afsA-3mczA:
undetectable		 1afsA-3mczA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 7 LEU A 313
HIS A 256
THR A  13
TYR A 338
 None
 1.22A 1afsB-3mczA:
undetectable		 1afsB-3mczA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 8 LEU A 280
VAL A 322
GLY A 321
TRP A 318
 None
 1.05A 1hrkA-3mczA:
undetectable		 1hrkA-3mczA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 8 LEU A 280
VAL A 322
GLY A 321
TRP A 318
 None
 1.04A 1hrkB-3mczA:
undetectable		 1hrkB-3mczA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 8 ASP A 182
GLY A 185
GLY A 188
LEU A 191
 None
 0.41A 1qzzA-3mczA:
25.6		 1qzzA-3mczA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 267
ALA A 270
ALA A 271
LEU A 328
LEU A 251
 None
 0.96A 1xlsA-3mczA:
undetectable		 1xlsA-3mczA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 LEU A  82
PHE A  47
LEU A  95
ILE A  37
VAL A 112
 None
 1.21A 2po5A-3mczA:
undetectable		 2po5A-3mczA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 6 ARG A 216
THR A 211
ALA A 215
PRO A 209
 None
 1.37A 2ql8A-3mczA:
undetectable
2ql8B-3mczA:
undetectable		 2ql8A-3mczA:
17.68
2ql8B-3mczA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 5 VAL A 168
VAL A 167
THR A 189
ARG A 333
 None
 0.90A 3bjwA-3mczA:
undetectable		 3bjwA-3mczA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 5 VAL A 168
VAL A 167
THR A 189
ARG A 333
 None
 0.88A 3bjwC-3mczA:
undetectable		 3bjwC-3mczA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 5 VAL A 168
VAL A 167
THR A 189
ARG A 333
 None
 0.99A 3bjwD-3mczA:
undetectable		 3bjwD-3mczA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 THR A 189
ILE A 205
GLY A 185
LEU A 224
THR A 211
 None
 1.16A 3eeyC-3mczA:
13.1		 3eeyC-3mczA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 THR A 189
ILE A 205
GLY A 185
LEU A 224
THR A 211
 None
 1.14A 3eeyE-3mczA:
13.3		 3eeyE-3mczA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 THR A  96
LEU A 100
LEU A  46
LEU A  82
LEU A  83
 None
 0.93A 3ndvA-3mczA:
undetectable
3ndvB-3mczA:
undetectable		 3ndvA-3mczA:
21.36
3ndvB-3mczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 LEU A  82
LEU A  83
THR A  96
LEU A 100
LEU A  46
 None
 0.95A 3ndvA-3mczA:
undetectable
3ndvB-3mczA:
undetectable		 3ndvA-3mczA:
21.36
3ndvB-3mczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 THR A  96
LEU A 100
LEU A  46
LEU A  82
LEU A  83
 None
 0.92A 3ndvC-3mczA:
undetectable
3ndvD-3mczA:
undetectable		 3ndvC-3mczA:
21.36
3ndvD-3mczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 LEU A  82
LEU A  83
THR A  96
LEU A 100
LEU A  46
 None
 0.95A 3ndvC-3mczA:
undetectable
3ndvD-3mczA:
undetectable		 3ndvC-3mczA:
21.36
3ndvD-3mczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 8 GLN A 204
PHE A 231
ILE A 181
GLY A 243
 None
 1.00A 4fgjA-3mczA:
2.2
4fgjB-3mczA:
2.1		 4fgjA-3mczA:
23.27
4fgjB-3mczA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 172
VAL A 173
MET A 250
LEU A 201
LEU A 281
 None
 1.28A 4yb6B-3mczA:
undetectable
4yb6C-3mczA:
undetectable		 4yb6B-3mczA:
22.70
4yb6C-3mczA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 172
VAL A 173
MET A 250
LEU A 201
LEU A 281
 None
 1.24A 4yb6C-3mczA:
undetectable
4yb6F-3mczA:
undetectable		 4yb6C-3mczA:
22.70
4yb6F-3mczA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 10 MET A 250
LEU A 201
LEU A 281
GLY A 172
VAL A 173
 None
 1.22A 4yb6A-3mczA:
undetectable
4yb6D-3mczA:
undetectable		 4yb6A-3mczA:
22.70
4yb6D-3mczA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 LEU A 302
MET A 305
VAL A 306
ASN A 121
 None
 1.21A 5b8iB-3mczA:
2.0		 5b8iB-3mczA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 GLY A 186
ASP A 207
ASN A 234
 None
 0.41A 5jglA-3mczA:
17.1		 5jglA-3mczA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 THR A 286
PRO A 294
ASP A  15
 None
 0.93A 5l8dB-3mczA:
undetectable		 5l8dB-3mczA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 THR A 286
PRO A 294
ASP A  15
 None
 0.93A 5mwuB-3mczA:
undetectable		 5mwuB-3mczA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 7 ALA A 184
GLY A 186
GLY A 188
ASN A 234
 None
 0.72A 5ybbB-3mczA:
10.2		 5ybbB-3mczA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3mcz O-METHYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 7 HIS A 187
THR A 189
HIS A 303
ASP A 253
 None
 1.09A 6mn4E-3mczA:
undetectable		 6mn4E-3mczA:
25.35