SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens) 		5 / 12 ILE A 491
GLN A 400
ILE A 395
CYH A 477
LEU A 457
 None
 1.06A 3dzuA-3mdaA:
undetectable		 3dzuA-3mdaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens) 		4 / 6 LEU A 286
SER A 288
PHE A 289
ILE A 302
 None
 0.96A 3ko0B-3mdaA:
undetectable		 3ko0B-3mdaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens) 		4 / 8 GLU A 315
TYR A 279
ARG A 323
ASP A 326
 None
 1.18A 3mjrD-3mdaA:
undetectable		 3mjrD-3mdaA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens) 		4 / 8 TYR A 496
PRO A 435
THR A 433
ILE A 432
 None
 0.72A 3p4wC-3mdaA:
undetectable		 3p4wC-3mdaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens) 		5 / 12 GLY A 508
LEU A 532
GLY A 524
THR A 522
PHE A 560
 None
 1.25A 5fsaB-3mdaA:
undetectable		 5fsaB-3mdaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens) 		4 / 8 TYR A 496
PRO A 435
THR A 433
ILE A 432
 None
 0.74A 5mzrE-3mdaA:
undetectable		 5mzrE-3mdaA:
12.76