SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 194
GLY A 244
ALA A 248
PRO A 189
ALA A 193
 None
 0.98A 1sg9C-3mdeA:
undetectable		 1sg9C-3mdeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 TYR A 133
GLY A 242
PHE A 194
SER A 182
 None
 1.37A 2a3cB-3mdeA:
undetectable		 2a3cB-3mdeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 255
PRO A 107
TYR A 133
 None
 0.82A 2dxrA-3mdeA:
undetectable		 2dxrA-3mdeA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ILE A 371
ALA A 260
GLY A 262
SER A 311
PRO A 257
 FAD  A 399 (-4.9A)
None
None
None
None
 0.97A 2okcA-3mdeA:
undetectable		 2okcA-3mdeA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ILE A 371
ALA A 260
GLY A 262
SER A 311
PRO A 257
 FAD  A 399 (-4.9A)
None
None
None
None
 0.96A 2okcB-3mdeA:
undetectable		 2okcB-3mdeA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 4 PRO A  49
TYR A  42
GLY A  93
THR A  92
 None
 1.15A 3ib0A-3mdeA:
undetectable		 3ib0A-3mdeA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ALA A 145
ARG A 181
LYS A 150
 CO8  A 400 (-3.5A)
None
None
 0.84A 3kp5B-3mdeA:
1.4		 3kp5B-3mdeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ARG A  44
THR A 358
ALA A  39
ALA A  40
 None
 1.09A 3ns1C-3mdeA:
undetectable		 3ns1C-3mdeA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 ILE A  77
GLY A 322
ALA A 315
ALA A 316
CYH A  81
 None
 1.01A 3sufD-3mdeA:
undetectable		 3sufD-3mdeA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ARG A 324
ASP A 253
ARG A 388
 CO8  A 400 (-4.2A)
CO8  A 400 (-3.6A)
CO8  A 400 ( 3.9A)
 1.00A 4mx0A-3mdeA:
undetectable		 4mx0A-3mdeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLN A  95
GLU A  99
GLY A 265
ALA A 267
ILE A 339
 CO8  A 400 ( 4.7A)
None
None
None
None
 1.17A 4xe5A-3mdeA:
2.6		 4xe5A-3mdeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 7 THR A  84
LEU A  87
THR A 102
THR A  64
 None
 0.77A 4z90A-3mdeA:
3.1
4z90B-3mdeA:
3.4
4z90C-3mdeA:
3.0
4z90D-3mdeA:
2.9
4z90E-3mdeA:
3.0		 4z90A-3mdeA:
21.09
4z90B-3mdeA:
21.09
4z90C-3mdeA:
21.09
4z90D-3mdeA:
21.09
4z90E-3mdeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 7 THR A  84
LEU A  87
THR A 102
THR A  64
 None
 0.87A 4z90A-3mdeA:
3.1
4z90B-3mdeA:
3.4
4z90C-3mdeA:
3.0
4z90D-3mdeA:
2.9
4z90E-3mdeA:
3.0		 4z90A-3mdeA:
21.09
4z90B-3mdeA:
21.09
4z90C-3mdeA:
21.09
4z90D-3mdeA:
21.09
4z90E-3mdeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 7 THR A  84
LEU A  87
THR A 102
THR A  64
 None
 0.82A 4z91F-3mdeA:
3.2
4z91G-3mdeA:
3.1
4z91H-3mdeA:
2.4
4z91I-3mdeA:
2.4
4z91J-3mdeA:
3.2		 4z91F-3mdeA:
21.09
4z91G-3mdeA:
21.09
4z91H-3mdeA:
21.09
4z91I-3mdeA:
21.09
4z91J-3mdeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 7 THR A 102
THR A  64
THR A  84
LEU A  87
 None
 0.77A 4z91F-3mdeA:
3.2
4z91G-3mdeA:
3.1
4z91H-3mdeA:
2.4
4z91I-3mdeA:
2.4
4z91J-3mdeA:
3.2		 4z91F-3mdeA:
21.09
4z91G-3mdeA:
21.09
4z91H-3mdeA:
21.09
4z91I-3mdeA:
21.09
4z91J-3mdeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 168
ALA A 100
ASN A 169
 FAD  A 399 (-4.0A)
CO8  A 400 ( 4.2A)
None
 0.43A 5ersA-3mdeA:
undetectable		 5ersA-3mdeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		4 / 8 LYS A 211
THR A 168
TYR A 176
PRO A  49
 None
FAD  A 399 (-4.0A)
None
None
 0.96A 5x2sI-3mdeA:
undetectable
5x2sJ-3mdeA:
undetectable
5x2sK-3mdeA:
undetectable		 5x2sI-3mdeA:
15.28
5x2sJ-3mdeA:
18.18
5x2sK-3mdeA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ARG A 314
ARG A 393
ARG A 323
 None
 0.95A 6bplA-3mdeA:
3.9
6bplB-3mdeA:
2.4		 6bplA-3mdeA:
10.70
6bplB-3mdeA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 10 GLY A 111
GLY A 112
ASN A 113
ILE A 247
GLY A 196
 None
 1.01A 6e5zA-3mdeA:
undetectable		 6e5zA-3mdeA:
18.73