SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mdq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.79A 1c9sI-3mdqA:
undetectable
1c9sJ-3mdqA:
undetectable		 1c9sI-3mdqA:
14.24
1c9sJ-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.76A 1c9sU-3mdqA:
undetectable
1c9sV-3mdqA:
undetectable		 1c9sU-3mdqA:
14.24
1c9sV-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 PHE A 187
VAL A 274
GLY A 161
GLY A 162
 None
 0.69A 1ekjE-3mdqA:
undetectable
1ekjF-3mdqA:
undetectable		 1ekjE-3mdqA:
23.00
1ekjF-3mdqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 161
GLY A 139
GLY A 138
GLU A 159
SER A 141
 None
SO4  A 317 (-3.8A)
SO4  A 317 (-3.3A)
None
SO4  A 317 (-3.8A)
 0.94A 1qtiA-3mdqA:
undetectable		 1qtiA-3mdqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.78A 1utdI-3mdqA:
undetectable
1utdJ-3mdqA:
undetectable		 1utdI-3mdqA:
14.24
1utdJ-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 147
THR A 204
HIS A 130
ILE A 146
 None
 0.78A 1utdJ-3mdqA:
undetectable
1utdK-3mdqA:
undetectable		 1utdJ-3mdqA:
14.24
1utdK-3mdqA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A 139
GLY A 161
ILE A  49
SER A  86
ARG A  85
 SO4  A 317 (-3.8A)
None
None
None
None
 1.02A 1x7pA-3mdqA:
undetectable
1x7pB-3mdqA:
undetectable		 1x7pA-3mdqA:
22.28
1x7pB-3mdqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A 161
ARG A 164
THR A  45
ILE A  44
THR A  12
 None
CL  A 316 (-4.3A)
CL  A 316 ( 4.4A)
None
SO4  A 317 (-4.0A)
 1.37A 2f9wA-3mdqA:
10.6
2f9wB-3mdqA:
10.7		 2f9wA-3mdqA:
22.43
2f9wB-3mdqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 8 THR A  12
GLY A 161
ARG A 164
THR A  45
ILE A  44
 SO4  A 317 (-4.0A)
None
CL  A 316 (-4.3A)
CL  A 316 ( 4.4A)
None
 1.37A 2f9wA-3mdqA:
10.6
2f9wB-3mdqA:
10.7		 2f9wA-3mdqA:
22.43
2f9wB-3mdqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 7 ALA A  72
ASP A  69
GLY A   6
ILE A   5
 None
 0.93A 2fxdB-3mdqA:
undetectable		 2fxdB-3mdqA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 5 ILE A 117
LEU A 298
ASP A 109
ALA A 114
 None
None
CL  A 315 ( 4.1A)
None
 1.05A 2opxA-3mdqA:
undetectable		 2opxA-3mdqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 206
ILE A 198
ILE A 279
MET A 135
PHE A 144
 None
 1.10A 2ygnA-3mdqA:
undetectable		 2ygnA-3mdqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		3 / 3 ILE A 207
PHE A 118
HIS A 130
 None
 0.74A 3h0aA-3mdqA:
undetectable		 3h0aA-3mdqA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A 138
THR A  81
ALA A 275
ASP A 136
ILE A 137
 SO4  A 317 (-3.3A)
SO4  A 317 (-4.3A)
None
None
None
 1.33A 3id5B-3mdqA:
undetectable		 3id5B-3mdqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A 138
THR A  81
ALA A 275
ASP A 136
ILE A 137
 SO4  A 317 (-3.3A)
SO4  A 317 (-4.3A)
None
None
None
 1.34A 3id5F-3mdqA:
undetectable		 3id5F-3mdqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 ILE A 152
SER A 132
GLY A 147
ASN A 150
 None
 0.95A 3lslA-3mdqA:
undetectable
3lslD-3mdqA:
undetectable		 3lslA-3mdqA:
22.19
3lslD-3mdqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 ASN A 150
ILE A 152
SER A 132
GLY A 147
 None
 0.88A 3lslA-3mdqA:
undetectable
3lslD-3mdqA:
undetectable		 3lslA-3mdqA:
22.19
3lslD-3mdqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 TYR A 236
ILE A 291
VAL A 293
ASP A 214
ILE A 279
 None
None
None
SO4  A 319 (-3.4A)
None
 1.27A 3vrjA-3mdqA:
undetectable
3vrjC-3mdqA:
undetectable		 3vrjA-3mdqA:
19.27
3vrjC-3mdqA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 5 GLY A 140
GLY A 139
ASN A  13
GLU A 159
 SO4  A 317 (-3.4A)
SO4  A 317 (-3.8A)
SO4  A 318 (-3.8A)
None
 1.22A 4fglC-3mdqA:
undetectable		 4fglC-3mdqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A  61
GLY A  40
ALA A  57
ASN A  89
GLY A  87
 None
 0.99A 4n09D-3mdqA:
undetectable		 4n09D-3mdqA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 161
ARG A 164
THR A  45
ILE A  44
THR A  12
 None
CL  A 316 (-4.3A)
CL  A 316 ( 4.4A)
None
SO4  A 317 (-4.0A)
 1.31A 4o5fA-3mdqA:
10.0
4o5fB-3mdqA:
3.6		 4o5fA-3mdqA:
24.71
4o5fB-3mdqA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 THR A  12
GLY A 161
ARG A 164
THR A  45
ILE A  44
 SO4  A 317 (-4.0A)
None
CL  A 316 (-4.3A)
CL  A 316 ( 4.4A)
None
 1.29A 4o5fA-3mdqA:
10.0
4o5fB-3mdqA:
3.6		 4o5fA-3mdqA:
24.71
4o5fB-3mdqA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 161
GLY A 139
THR A  12
ILE A  44
ILE A 166
 None
SO4  A 317 (-3.8A)
SO4  A 317 (-4.0A)
None
None
 1.27A 4zvmA-3mdqA:
undetectable
4zvmB-3mdqA:
undetectable		 4zvmA-3mdqA:
21.05
4zvmB-3mdqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 161
ARG A 164
THR A  45
ILE A  44
THR A  12
 None
CL  A 316 (-4.3A)
CL  A 316 ( 4.4A)
None
SO4  A 317 (-4.0A)
 1.30A 5b8hA-3mdqA:
9.8
5b8hB-3mdqA:
5.8		 5b8hA-3mdqA:
22.99
5b8hB-3mdqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 THR A  12
GLY A 161
ARG A 164
THR A  45
ILE A  44
 SO4  A 317 (-4.0A)
None
CL  A 316 (-4.3A)
CL  A 316 ( 4.4A)
None
 1.29A 5b8hA-3mdqA:
9.8
5b8hB-3mdqA:
3.8		 5b8hA-3mdqA:
22.99
5b8hB-3mdqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 ILE A 207
PHE A 144
GLY A 147
ILE A 146
LEU A 278
 None
 0.90A 5e72A-3mdqA:
undetectable		 5e72A-3mdqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 9 GLN A 156
PHE A 144
GLU A 195
LEU A 278
ILE A 160
 None
 1.26A 5i73A-3mdqA:
undetectable		 5i73A-3mdqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 8 GLU A 143
GLU A 113
GLY A 138
THR A  12
 None
SO4  A 317 ( 4.8A)
SO4  A 317 (-3.3A)
SO4  A 317 (-4.0A)
 0.96A 5sxqA-3mdqA:
1.2		 5sxqA-3mdqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 268
VAL A 282
LEU A 206
SER A 210
ILE A 137
 SO4  A 319 ( 2.9A)
None
None
None
None
 1.14A 5vooB-3mdqA:
3.8		 5vooB-3mdqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		4 / 5 GLY A  87
ARG A  85
GLN A 163
MET A 271
 None
None
None
SO4  A 318 (-4.6A)
 1.44A 5zrfB-3mdqA:
undetectable		 5zrfB-3mdqA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3mdq EXOPOLYPHOSPHATASE
(Cytophaga
hutchinsonii) 		3 / 3 ARG A 119
PHE A 118
GLY A 120
 None
 0.80A 6fgdA-3mdqA:
undetectable		 6fgdA-3mdqA:
23.81