SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3me5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 PHE A  87
GLU A 451
LEU A 450
MET A 220
 None
 0.98A 1hk1A-3me5A:
undetectable		 1hk1A-3me5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 7 PHE A  87
GLU A 451
LEU A 450
MET A 220
 None
 1.00A 1hk3A-3me5A:
undetectable		 1hk3A-3me5A:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 8 PHE A  93
GLU A 115
ILE A 141
PRO A 176
LEU A 205
 None
 0.56A 1hmyA-3me5A:
27.8		 1hmyA-3me5A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 ASP A 293
ASP A 298
LYS A 453
 None
 0.93A 1lqtB-3me5A:
3.3		 1lqtB-3me5A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 ASP A 293
ASP A 298
LYS A 453
 None
 0.90A 1lquB-3me5A:
2.8		 1lquB-3me5A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 213
THR A 145
ILE A 141
ILE A 212
THR A 244
 None
 1.03A 1rd7B-3me5A:
undetectable		 1rd7B-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 213
THR A 145
ILE A 141
ILE A 212
THR A 244
 None
 1.00A 1re7A-3me5A:
undetectable		 1re7A-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 LEU A 172
PHE A 137
HIS A 128
ARG A 101
PHE A  89
 None
 1.37A 1skxA-3me5A:
undetectable		 1skxA-3me5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 THR A 237
PHE A 180
PHE A 175
ASN A 225
 None
 1.49A 1tt0A-3me5A:
undetectable		 1tt0A-3me5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 THR A 237
PHE A 180
PHE A 175
ASN A 225
 None
 1.50A 1tt0C-3me5A:
2.5		 1tt0C-3me5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 THR A 237
PHE A 180
PHE A 175
ASN A 225
 None
 1.50A 1tt0D-3me5A:
2.4		 1tt0D-3me5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.25A 2d0kB-3me5A:
undetectable		 2d0kB-3me5A:
17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		7 / 12 PHE A  93
GLY A  95
GLY A  98
ASP A 140
ILE A 141
PRO A 176
VAL A 438
 None
 0.96A 2hmyB-3me5A:
27.8		 2hmyB-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		7 / 12 PHE A  93
GLY A  95
GLY A  98
ILE A 141
PRO A 176
LEU A 205
VAL A 438
 None
 0.55A 2hmyB-3me5A:
27.8		 2hmyB-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  97
ILE A 141
PRO A 176
LEU A 205
 None
 0.83A 2hmyB-3me5A:
27.8		 2hmyB-3me5A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 ASP A 377
ARG A 400
ARG A 378
 None
 1.04A 2j9dA-3me5A:
undetectable
2j9dC-3me5A:
undetectable		 2j9dA-3me5A:
13.07
2j9dC-3me5A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 266
VAL A 282
LEU A 450
PHE A 103
PHE A 443
 None
 1.20A 2jj8C-3me5A:
undetectable		 2jj8C-3me5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 PRO A 218
MET A 220
ASP A 251
TYR A 250
 None
 1.45A 2lh8A-3me5A:
undetectable		 2lh8A-3me5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 ARG A 405
ASN A 436
THR A 123
 None
 0.82A 2q63A-3me5A:
undetectable		 2q63A-3me5A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A 137
ILE A  27
PHE A 421
PHE A 413
ALA A  94
 None
 1.22A 3apwA-3me5A:
undetectable		 3apwA-3me5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 PHE A  93
GLY A  95
GLY A  98
LEU A 205
ASN A 436
VAL A 438
 None
 0.72A 3av6A-3me5A:
12.3		 3av6A-3me5A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 PHE A  93
GLY A  95
GLY A  98
PRO A 176
LEU A 205
VAL A 438
 None
 0.95A 3av6A-3me5A:
12.3		 3av6A-3me5A:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  97
ILE A 141
LEU A 205
ASN A 436
 None
 0.95A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  97
ILE A 141
PRO A 176
LEU A 205
 None
 0.98A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  98
ASP A 140
ILE A 141
ASN A 436
 None
 1.09A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  98
ILE A 141
LEU A 205
ASN A 436
 None
 0.69A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  98
ILE A 141
PRO A 176
LEU A 205
 None
 0.64A 3eeoA-3me5A:
23.7		 3eeoA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 GLU A 115
SER A 437
VAL A 438
 None
 0.33A 3eeoA-3me5A:
26.8		 3eeoA-3me5A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 ASN A  43
ILE A  49
GLU A  67
ASN A  38
 None
 1.32A 3kp6A-3me5A:
undetectable
3kp6B-3me5A:
undetectable		 3kp6A-3me5A:
18.58
3kp6B-3me5A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 9 LEU A 281
ILE A  90
PHE A 206
GLU A 224
VAL A 209
 None
 1.46A 3tmzA-3me5A:
undetectable		 3tmzA-3me5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 5 GLY A  97
ILE A  96
VAL A 440
SER A 437
 None
 1.17A 4d33A-3me5A:
undetectable		 4d33A-3me5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 5 GLY A  97
ILE A  96
VAL A 440
SER A 437
 None
 1.19A 4d33B-3me5A:
undetectable		 4d33B-3me5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 7 TYR A 124
ALA A  94
GLY A  95
ILE A  99
GLY A  98
 None
 1.35A 4eatA-3me5A:
2.4		 4eatA-3me5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 5 PHE A 434
PHE A 421
ILE A  96
GLY A  97
 None
 0.95A 4ejjC-3me5A:
undetectable		 4ejjC-3me5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 6 GLY A 107
GLY A 108
GLU A 451
ILE A 454
 None
 0.94A 4fglD-3me5A:
3.9		 4fglD-3me5A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.23A 4fhbA-3me5A:
undetectable		 4fhbA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 TYR A 129
ARG A 100
HIS A 135
 None
 1.25A 4fubA-3me5A:
undetectable		 4fubA-3me5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.25A 4kjlA-3me5A:
undetectable		 4kjlA-3me5A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 8 GLY A 371
LEU A 314
LEU A 313
GLU A 406
 None
 0.82A 4mwzB-3me5A:
undetectable		 4mwzB-3me5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.20A 4pthA-3me5A:
undetectable		 4pthA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 213
THR A 145
ILE A 141
ILE A 212
THR A 244
 None
 1.06A 4ptjA-3me5A:
undetectable		 4ptjA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 GLN A 149
HIS A 148
ARG A 142
 None
 1.29A 4qyqA-3me5A:
undetectable		 4qyqA-3me5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.19A 4x5gB-3me5A:
undetectable		 4x5gB-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.10A 4x5iA-3me5A:
undetectable		 4x5iA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 213
THR A 145
ILE A 141
ILE A 212
THR A 244
 None
 0.97A 4x5jA-3me5A:
undetectable		 4x5jA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 213
THR A 145
ILE A 141
ILE A 212
THR A 244
 None
 0.98A 5e8qA-3me5A:
undetectable		 5e8qA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.18A 5eajA-3me5A:
undetectable		 5eajA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 11 PHE A  93
GLY A  95
GLU A 115
ASN A 117
PRO A 176
 None
 0.70A 5hjiA-3me5A:
8.4		 5hjiA-3me5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		4 / 7 PHE A  89
ASP A  91
GLY A 102
GLY A  98
 None
 1.02A 5n9xA-3me5A:
3.3		 5n9xA-3me5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		3 / 3 GLU A  67
HIS A  70
VAL A  40
 None
 0.81A 5trqB-3me5A:
undetectable		 5trqB-3me5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.19A 5ujxA-3me5A:
undetectable		 5ujxA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.22A 5z6jA-3me5A:
undetectable		 5z6jA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		6 / 12 ILE A 213
THR A 145
ILE A 141
LEU A  92
ILE A 212
THR A 244
 None
 1.22A 5z6kA-3me5A:
undetectable		 5z6kA-3me5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 10 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
 None
 1.11A 6ebpB-3me5A:
undetectable		 6ebpB-3me5A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 10 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
 None
 1.12A 6ebpC-3me5A:
undetectable		 6ebpC-3me5A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 10 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
 None
 1.10A 6ebpD-3me5A:
undetectable		 6ebpD-3me5A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 11 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
 None
 1.06A 6gp2B-3me5A:
undetectable		 6gp2B-3me5A:
9.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		8 / 12 PHE A  93
GLY A  95
GLY A  98
ASP A 140
ILE A 141
ASN A 436
SER A 437
VAL A 438
 None
 0.87A 6mhtA-3me5A:
25.4		 6mhtA-3me5A:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 PHE A  93
GLY A  97
ILE A 141
ASN A 436
SER A 437
 None
 1.06A 6mhtA-3me5A:
25.4		 6mhtA-3me5A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Shigella
flexneri) 		5 / 12 ILE A 213
THR A 145
ILE A 141
ILE A 212
THR A 244
 None
 1.01A 7dfrA-3me5A:
undetectable		 7dfrA-3me5A:
17.58