SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3meb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 5 THR A 372
THR A 374
THR A 352
HIS A 344
 None
 1.42A 1d4fB-3mebA:
undetectable		 1d4fB-3mebA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 4 LEU A 158
GLY A 195
ASP A 197
TYR A 157
 None
None
EDO  A 506 (-3.8A)
EDO  A 506 (-4.3A)
 1.12A 1oxrA-3mebA:
undetectable		 1oxrA-3mebA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 4 LEU A 365
LEU A 347
SER A 346
LEU A 342
 None
 1.14A 1ya3A-3mebA:
undetectable		 1ya3A-3mebA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		3 / 3 TRP A 203
THR A 171
TYR A 155
 EDO  A 506 (-4.3A)
None
None
 1.07A 2a3aA-3mebA:
undetectable		 2a3aA-3mebA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		3 / 3 TRP A 203
THR A 171
TYR A 155
 EDO  A 506 (-4.3A)
None
None
 1.03A 2a3aB-3mebA:
undetectable		 2a3aB-3mebA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		3 / 3 TRP A 203
THR A 171
TYR A 155
 EDO  A 506 (-4.3A)
None
None
 1.10A 2a3bA-3mebA:
undetectable		 2a3bA-3mebA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		3 / 3 SER A 286
GLU A  96
ASP A 243
 None
None
EDO  A 505 (-3.6A)
 0.88A 2avdB-3mebA:
2.4		 2avdB-3mebA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 4 SER A 110
GLY A 266
HIS A 187
ASP A 197
 None
None
EDO  A 506 (-4.7A)
EDO  A 506 (-3.8A)
 1.32A 2oxtC-3mebA:
undetectable		 2oxtC-3mebA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 6 ILE A 364
ASP A 382
GLY A 397
VAL A 420
 None
 0.88A 3n3iA-3mebA:
undetectable		 3n3iA-3mebA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 4 GLY A  36
GLY A  34
THR A  19
LEU A  16
 SO4  A 501 (-4.0A)
EDO  A 502 ( 4.9A)
None
None
 0.93A 3si7C-3mebA:
undetectable
3si7D-3mebA:
undetectable		 3si7C-3mebA:
23.13
3si7D-3mebA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 7 PHE A 218
GLY A 107
ILE A 140
PHE A 115
 None
SO4  A 500 ( 3.2A)
None
None
 0.92A 4ejjA-3mebA:
undetectable		 4ejjA-3mebA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 5 LEU A 376
MET A 401
LEU A 343
HIS A 363
 None
 1.34A 4xi3B-3mebA:
undetectable		 4xi3B-3mebA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 7 ILE A  47
VAL A  51
ILE A 311
GLU A 263
 None
 0.73A 4zzbC-3mebA:
undetectable
4zzbD-3mebA:
undetectable		 4zzbC-3mebA:
22.17
4zzbD-3mebA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		3 / 3 TYR A 157
THR A 156
THR A 132
 EDO  A 506 (-4.3A)
None
None
 0.83A 5aoxB-3mebA:
undetectable		 5aoxB-3mebA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 6 SER A 131
GLU A 154
GLY A 375
GLY A 396
 None
 0.94A 5cdpA-3mebA:
undetectable
5cdpB-3mebA:
undetectable		 5cdpA-3mebA:
22.87
5cdpB-3mebA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		4 / 8 ILE A 315
PHE A 325
VAL A 316
GLN A 323
 None
 1.19A 5dqyA-3mebA:
undetectable		 5dqyA-3mebA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		5 / 12 LEU A 249
LEU A 268
ALA A 251
LEU A 111
ILE A 216
 None
 1.05A 5toaA-3mebA:
undetectable		 5toaA-3mebA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		3 / 3 GLU A 116
HIS A 119
VAL A 144
 None
 0.91A 5trqB-3mebA:
undetectable		 5trqB-3mebA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3meb ASPARTATE
AMINOTRANSFERASE
(Giardia
intestinalis) 		5 / 12 GLY A 107
VAL A 329
PHE A  78
VAL A 312
ILE A 265
 SO4  A 500 ( 3.2A)
None
None
None
None
 1.13A 5tuiB-3mebA:
undetectable		 5tuiB-3mebA:
21.75