SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3men'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		7 / 11 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.38A 1c3sA-3menA:
36.9		 1c3sA-3menA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 7 HIS A 156
LEU A 278
SER A 277
ASP A 190
 SO4  A 401 (-3.6A)
None
None
K  A 402 (-3.0A)
 1.04A 1ismB-3menA:
undetectable		 1ismB-3menA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 8 SER A 277
ILE A 202
PHE A 203
VAL A 186
 None
 0.99A 1kb9A-3menA:
undetectable
1kb9C-3menA:
undetectable
1kb9D-3menA:
undetectable
1kb9E-3menA:
undetectable		 1kb9A-3menA:
21.14
1kb9C-3menA:
20.96
1kb9D-3menA:
22.05
1kb9E-3menA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		6 / 12 ASP A 113
HIS A 156
HIS A 157
GLY A 165
ASP A 192
HIS A 194
 None
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
 1.44A 1t69A-3menA:
36.4		 1t69A-3menA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.45A 1t69A-3menA:
36.4		 1t69A-3menA:
26.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 11 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.45A 1zz1A-3menA:
40.8		 1zz1A-3menA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.17A 1zz1A-3menA:
40.8		 1zz1A-3menA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.41A 1zz1B-3menA:
41.2
1zz1C-3menA:
41.0		 1zz1B-3menA:
33.08
1zz1C-3menA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.16A 1zz1B-3menA:
41.2
1zz1C-3menA:
41.0		 1zz1B-3menA:
33.08
1zz1C-3menA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		7 / 12 ASP A 113
HIS A 156
GLY A 165
ASP A 192
ASP A 281
GLY A 318
TYR A 320
 None
SO4  A 401 (-3.6A)
SO4  A 401 (-4.9A)
ZN  A 400 (-2.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.88A 1zz1C-3menA:
41.0		 1zz1C-3menA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 HIS A 156
HIS A 157
GLY A 165
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.44A 1zz1C-3menA:
41.0		 1zz1C-3menA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		7 / 9 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.47A 1zz1D-3menA:
40.9		 1zz1D-3menA:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 4 ALA A 253
VAL A 291
PHE A 256
THR A 294
 None
 1.36A 2pkkA-3menA:
undetectable		 2pkkA-3menA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 VAL A 160
ASP A 161
GLU A 201
 None
 0.71A 2qeuA-3menA:
undetectable		 2qeuA-3menA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 VAL A 160
ASP A 161
GLU A 201
 None
 0.72A 2qeuC-3menA:
undetectable		 2qeuC-3menA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A 203
PRO A 271
ALA A 270
ALA A 173
ALA A 175
 None
 1.13A 2x2nA-3menA:
undetectable		 2x2nA-3menA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A 203
PRO A 271
ALA A 270
ALA A 173
ALA A 175
 None
 1.09A 2x2nB-3menA:
undetectable		 2x2nB-3menA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 HIS A 194
HIS A 157
HIS A 156
 ZN  A 400 (-3.3A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.6A)
 0.76A 2y69N-3menA:
undetectable		 2y69N-3menA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 HIS A 194
HIS A 157
HIS A 156
 ZN  A 400 (-3.3A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.6A)
 0.77A 2zxwN-3menA:
undetectable		 2zxwN-3menA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 HIS A 194
HIS A 157
HIS A 156
 ZN  A 400 (-3.3A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.6A)
 0.75A 3abmN-3menA:
undetectable		 3abmN-3menA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A   9
CYH A 167
ALA A 149
VAL A 315
HIS A  62
 None
SO4  A 401 ( 4.2A)
None
None
None
 1.12A 3b0wA-3menA:
undetectable		 3b0wA-3menA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 GLN A   9
CYH A 167
ALA A 149
VAL A 315
HIS A  62
 None
SO4  A 401 ( 4.2A)
None
None
None
 1.14A 3b0wB-3menA:
undetectable		 3b0wB-3menA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 5 HIS A 156
HIS A 157
ASP A 192
HIS A 194
ASP A 281
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
 0.18A 3c0zA-3menA:
38.4		 3c0zA-3menA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		7 / 8 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
 0.29A 3c0zB-3menA:
38.7		 3c0zB-3menA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 6 ASP A 113
HIS A 156
HIS A 157
ASP A 192
HIS A 194
 None
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
 1.48A 3c0zC-3menA:
38.8		 3c0zC-3menA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 6 HIS A 156
HIS A 157
ASP A 192
HIS A 194
ASP A 281
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
 0.22A 3c0zC-3menA:
38.8		 3c0zC-3menA:
30.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A 159
GLU A 231
TYR A 211
 None
 0.92A 3k37B-3menA:
undetectable		 3k37B-3menA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 GLN A 288
HIS A 157
HIS A 156
ASP A 281
 SO4  A 401 ( 4.7A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.6A)
ZN  A 400 ( 2.6A)
 1.01A 3nvcA-3menA:
undetectable		 3nvcA-3menA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 PHE A 280
LEU A 276
PHE A 333
THR A   3
 None
 1.00A 3t3zB-3menA:
undetectable		 3t3zB-3menA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 8 PHE A 280
THR A 191
GLY A 302
SER A 331
 None
 1.05A 3tzfB-3menA:
undetectable		 3tzfB-3menA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 10 HIS A 156
HIS A 157
ASP A 192
HIS A 194
ASP A 281
PRO A 287
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.61A 4bz6A-3menA:
35.8		 4bz6A-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 HIS A 156
HIS A 157
ASP A 192
HIS A 194
ASP A 281
PRO A 287
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.59A 4bz6A-3menA:
35.8
4bz6B-3menA:
35.7		 4bz6A-3menA:
21.43
4bz6B-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		6 / 12 HIS A 157
HIS A 194
ASP A 281
PRO A 287
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.47A 4bz6A-3menA:
35.8
4bz6B-3menA:
35.7		 4bz6A-3menA:
21.43
4bz6B-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 HIS A 156
HIS A 157
GLY A 165
ASP A 192
HIS A 194
ASP A 281
PRO A 287
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.59A 4bz6C-3menA:
35.7		 4bz6C-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		6 / 12 HIS A 157
HIS A 194
ASP A 281
PRO A 287
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.50A 4bz6C-3menA:
35.7		 4bz6C-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 10 HIS A 156
HIS A 157
ASP A 192
HIS A 194
ASP A 281
PRO A 287
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.63A 4bz6D-3menA:
35.8		 4bz6D-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 10 HIS A 156
HIS A 194
ASP A 281
GLY A 319
TYR A 320
 SO4  A 401 (-3.6A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 (-4.5A)
 1.25A 4bz6D-3menA:
35.8		 4bz6D-3menA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 LEU A 301
LEU A 304
ILE A 305
LEU A 189
LEU A 244
 None
 1.17A 4dm8A-3menA:
undetectable		 4dm8A-3menA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 HIS A 321
SER A 324
LEU A 276
ASP A 192
GLY A 318
 None
None
None
ZN  A 400 (-2.3A)
SO4  A 401 ( 3.7A)
 1.30A 4fogC-3menA:
undetectable		 4fogC-3menA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 ARG A 258
GLY A 216
ASP A 217
GLY A 227
 None
None
IOD  A 342 ( 4.5A)
None
 0.95A 4koeA-3menA:
undetectable
4koeB-3menA:
undetectable
4koeC-3menA:
undetectable		 4koeA-3menA:
20.83
4koeB-3menA:
20.83
4koeC-3menA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.36A 4lxzA-3menA:
38.4		 4lxzA-3menA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.18A 4lxzA-3menA:
38.4		 4lxzA-3menA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 11 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.34A 4lxzB-3menA:
38.2		 4lxzB-3menA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.16A 4lxzB-3menA:
38.2		 4lxzB-3menA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.37A 4lxzC-3menA:
38.4		 4lxzC-3menA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFQ_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 MET A  80
TRP A  84
TRP A  77
ALA A 107
 None
 1.48A 4mfqA-3menA:
0.0		 4mfqA-3menA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 337
ALA A 338
GLY A 335
LEU A 304
GLY A 306
 None
 0.95A 4o3fA-3menA:
3.6		 4o3fA-3menA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.43A 4qa0A-3menA:
36.4		 4qa0A-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 156
HIS A 194
ASP A 281
GLY A 319
TYR A 320
 SO4  A 401 (-3.6A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 (-4.5A)
 1.24A 4qa0A-3menA:
36.4		 4qa0A-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.09A 4qa0A-3menA:
36.4		 4qa0A-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 11 HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.48A 4qa0B-3menA:
36.4		 4qa0B-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 HIS A 156
PHE A 166
ASP A 281
GLY A 319
TYR A 320
 SO4  A 401 (-3.6A)
None
ZN  A 400 ( 2.6A)
None
SO4  A 401 (-4.5A)
 1.29A 4qa0B-3menA:
36.4		 4qa0B-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 HIS A 156
PHE A 166
HIS A 194
ASP A 281
TYR A 320
 SO4  A 401 (-3.6A)
None
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.21A 4qa0B-3menA:
36.4		 4qa0B-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 11 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.12A 4qa0B-3menA:
36.4		 4qa0B-3menA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.42A 4qa2A-3menA:
36.0		 4qa2A-3menA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.11A 4qa2A-3menA:
36.0		 4qa2A-3menA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.38A 4qa2B-3menA:
36.9		 4qa2B-3menA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 156
HIS A 194
ASP A 281
GLY A 319
TYR A 320
 SO4  A 401 (-3.6A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 (-4.5A)
 1.24A 4qa2B-3menA:
36.9		 4qa2B-3menA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 HIS A 157
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 1.10A 4qa2B-3menA:
36.9		 4qa2B-3menA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A 166
HIS A 194
ASP A 281
GLY A 319
TYR A 320
 None
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
None
SO4  A 401 (-4.5A)
 1.23A 4qa2B-3menA:
36.9		 4qa2B-3menA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 GLN A 200
HIS A 195
GLU A 231
ARG A 159
 IOD  A 349 ( 4.8A)
None
None
None
 1.44A 4qyqC-3menA:
undetectable		 4qyqC-3menA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 174
TYR A 127
ASP A  63
THR A  64
ILE A  55
 None
 1.41A 4xe0A-3menA:
undetectable		 4xe0A-3menA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 GLY A 216
ASP A 217
GLY A 227
ARG A 258
 None
IOD  A 342 ( 4.5A)
None
None
 1.01A 4z53A-3menA:
1.7
4z53B-3menA:
1.4		 4z53A-3menA:
18.69
4z53B-3menA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 SER A  19
HIS A 157
HIS A 194
ASP A 281
TYR A 320
 IOD  A 345 ( 3.4A)
SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.12A 5eeiA-3menA:
40.4		 5eeiA-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 SER A 115
HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 IOD  A 347 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.42A 5eeiA-3menA:
40.4		 5eeiA-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 SER A  19
HIS A 157
HIS A 194
ASP A 281
TYR A 320
 IOD  A 345 ( 3.4A)
SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.13A 5eeiB-3menA:
40.3		 5eeiB-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 SER A 115
HIS A 156
HIS A 157
GLY A 165
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 IOD  A 347 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
SO4  A 401 (-4.9A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.43A 5eeiB-3menA:
40.3		 5eeiB-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 SER A  19
HIS A 157
HIS A 194
ASP A 281
TYR A 320
 IOD  A 345 ( 3.4A)
SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.10A 5eenA-3menA:
40.2		 5eenA-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		9 / 12 SER A 115
HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
GLY A 318
TYR A 320
 IOD  A 347 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 ( 3.7A)
SO4  A 401 (-4.5A)
 0.38A 5eenA-3menA:
40.2		 5eenA-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 SER A  19
HIS A 157
HIS A 194
ASP A 281
TYR A 320
 IOD  A 345 ( 3.4A)
SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.11A 5eenB-3menA:
40.4		 5eenB-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 SER A 115
HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 IOD  A 347 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.40A 5eenB-3menA:
40.4		 5eenB-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 SER A  19
HIS A 157
HIS A 194
ASP A 281
TYR A 320
 IOD  A 345 ( 3.4A)
SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.13A 5ef8A-3menA:
40.3		 5ef8A-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 SER A 115
HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 IOD  A 347 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.41A 5ef8A-3menA:
40.3		 5ef8A-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 SER A  19
HIS A 157
HIS A 194
ASP A 281
TYR A 320
 IOD  A 345 ( 3.4A)
SO4  A 401 (-3.4A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 1.15A 5ef8B-3menA:
40.2		 5ef8B-3menA:
31.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		8 / 12 SER A 115
HIS A 156
HIS A 157
PHE A 166
ASP A 192
HIS A 194
ASP A 281
TYR A 320
 IOD  A 347 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-3.4A)
None
ZN  A 400 (-2.3A)
ZN  A 400 (-3.3A)
ZN  A 400 ( 2.6A)
SO4  A 401 (-4.5A)
 0.39A 5ef8B-3menA:
40.2		 5ef8B-3menA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 5 GLN A 200
HIS A 195
GLU A 231
ARG A 159
 IOD  A 349 ( 4.8A)
None
None
None
 1.37A 5hpwA-3menA:
0.0		 5hpwA-3menA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 6 GLN A 200
HIS A 195
GLU A 231
ARG A 159
 IOD  A 349 ( 4.8A)
None
None
None
 1.44A 5hpwC-3menA:
undetectable		 5hpwC-3menA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 5 TYR A 320
LEU A 278
GLY A 279
PHE A 280
 SO4  A 401 (-4.5A)
None
None
None
 0.89A 5kmdC-3menA:
undetectable
5kmdD-3menA:
undetectable		 5kmdC-3menA:
19.20
5kmdD-3menA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		4 / 7 GLY A 279
GLN A  27
ASP A 286
TYR A 283
 None
 1.28A 5vlmG-3menA:
undetectable		 5vlmG-3menA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 HIS A 194
HIS A 157
HIS A 156
 ZN  A 400 (-3.3A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.6A)
 0.76A 5z86A-3menA:
undetectable		 5z86A-3menA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		3 / 3 HIS A 194
HIS A 157
HIS A 156
 ZN  A 400 (-3.3A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.6A)
 0.78A 5z86N-3menA:
undetectable		 5z86N-3menA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3men ACETYLPOLYAMINE
AMINOHYDROLASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 297
ILE A 314
GLY A 335
SER A 331
ALA A 329
 None
 1.20A 6c2mB-3menA:
undetectable		 6c2mB-3menA:
10.50