SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mfg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E3V_A_DXCA801_0 (STEROID DELTA-ISOMERASE)	3mfg	V_SEGMENT TRANSLATION PRODUCT (Homo sapiens)	5 / 12	TYR B 90 PHE B 38 PHE B 65 VAL B 60 ASP B 86	None	1.39A	1e3vA-3mfgB: undetectable	1e3vA-3mfgB: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_C_C2FC1410_0 (GLYCINE N-METHYLTRANSFERASE)	3mfg	V_SEGMENT TRANSLATION PRODUCT (Homo sapiens)	3 / 3	ARG B 112 PRO B 109 PHE B 89	SO4 B 117 (-4.1A) None None	1.03A	3thrC-3mfgB: undetectable	3thrC-3mfgB: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVW_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	3mfg	V_SEGMENT TRANSLATION PRODUCT (Homo sapiens)	5 / 11	ALA B 54 THR B 55 ALA B 47 GLY B 52 SER B 75	None	1.08A	4qvwK-3mfgB: undetectable 4qvwL-3mfgB: undetectable	4qvwK-3mfgB: 19.91 4qvwL-3mfgB: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVW_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	3mfg	V_SEGMENT TRANSLATION PRODUCT (Homo sapiens)	5 / 11	ALA B 54 THR B 55 ALA B 47 GLY B 52 SER B 75	None	1.08A	4qvwY-3mfgB: undetectable 4qvwZ-3mfgB: undetectable	4qvwY-3mfgB: 19.91 4qvwZ-3mfgB: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	3mfg	V_SEGMENT TRANSLATION PRODUCT (Homo sapiens)	5 / 12	ILE B 67 THR B 76 THR B 111 SER B 5 VAL B 4	None	1.24A	6bzoC-3mfgB: undetectable	6bzoC-3mfgB: 7.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E3V_A_DXCA801_0","STEROID DELTA-ISOMERASE","3mfg","V_SEGMENT TRANSLATION PRODUCT","Homo sapiens",5,"TYR B  90;PHE B  38;PHE B  65;VAL B  60;ASP B  86","None","1.39A","1e3vA-3mfgB:undetectable","1e3vA-3mfgB:21.58"],["3THR_C_C2FC1410_0","GLYCINE N-METHYLTRANSFERASE","3mfg","V_SEGMENT TRANSLATION PRODUCT","Homo sapiens",3,"ARG B 112;PRO B 109;PHE B  89","SO4 B 117 (-4.1A);None;None","1.03A","3thrC-3mfgB:undetectable","3thrC-3mfgB:20.07"],["4QVW_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","3mfg","V_SEGMENT TRANSLATION PRODUCT","Homo sapiens",5,"ALA B  54;THR B  55;ALA B  47;GLY B  52;SER B  75","None","1.08A","4qvwK-3mfgB:undetectable;4qvwL-3mfgB:undetectable","4qvwK-3mfgB:19.91;4qvwL-3mfgB:19.00"],["4QVW_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","3mfg","V_SEGMENT TRANSLATION PRODUCT","Homo sapiens",5,"ALA B  54;THR B  55;ALA B  47;GLY B  52;SER B  75","None","1.08A","4qvwY-3mfgB:undetectable;4qvwZ-3mfgB:undetectable","4qvwY-3mfgB:19.91;4qvwZ-3mfgB:19.00"],["6BZO_C_FI8C1201_0","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","3mfg","V_SEGMENT TRANSLATION PRODUCT","Homo sapiens",5,"ILE B  67;THR B  76;THR B 111;SER B   5;VAL B   4","None","1.24A","6bzoC-3mfgB:undetectable","6bzoC-3mfgB:7.61"]]