SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 5 THR A 219
ASP A 281
HIS A 131
HIS A 197
 ZN  A 401 ( 4.8A)
ZN  A 401 (-2.1A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
 1.21A 1ei6A-3mfqA:
undetectable		 1ei6A-3mfqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 8 PRO A  67
THR A 248
GLY A  64
THR A  40
 None
 0.82A 1h4oB-3mfqA:
undetectable		 1h4oB-3mfqA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 8 PRO A  67
THR A 248
GLY A  64
THR A  40
 None
 0.85A 1oc3A-3mfqA:
undetectable		 1oc3A-3mfqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		5 / 12 LEU A  69
HIS A  68
ASP A  66
THR A 248
GLY A 216
 None
ZN  A 401 (-3.6A)
None
None
None
 0.85A 1v8bB-3mfqA:
undetectable		 1v8bB-3mfqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		5 / 11 VAL A 305
ILE A 186
LEU A 183
ILE A 240
PHE A 209
 None
 1.17A 2dg9A-3mfqA:
undetectable		 2dg9A-3mfqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 PHE A  42
SER A 247
LEU A 278
 None
 0.68A 2w1bA-3mfqA:
undetectable		 2w1bA-3mfqA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		5 / 12 VAL A  98
ALA A 100
THR A  39
ILE A  61
PRO A  62
 None
 1.00A 3clbC-3mfqA:
undetectable		 3clbC-3mfqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		5 / 12 LEU A  69
HIS A  68
ASP A  66
THR A 248
GLY A 216
 None
ZN  A 401 (-3.6A)
None
None
None
 0.91A 3g1uD-3mfqA:
undetectable		 3g1uD-3mfqA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 HIS A 131
HIS A  68
HIS A 197
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.6A)
ZN  A 401 (-3.4A)
 0.49A 3qpkA-3mfqA:
undetectable		 3qpkA-3mfqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 HIS A 131
HIS A  68
HIS A 197
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.6A)
ZN  A 401 (-3.4A)
 0.49A 3qpkB-3mfqA:
undetectable		 3qpkB-3mfqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 8 ILE A 136
TYR A 207
LEU A 183
PHE A 203
 None
 0.83A 3rqwI-3mfqA:
undetectable
3rqwJ-3mfqA:
undetectable		 3rqwI-3mfqA:
20.12
3rqwJ-3mfqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 HIS A  68
SER A 247
GLU A 246
 ZN  A 401 (-3.6A)
None
None
 0.83A 3s8pA-3mfqA:
undetectable		 3s8pA-3mfqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 6 GLY A 273
LEU A 303
TYR A 307
GLU A 269
 None
 1.03A 3w9tB-3mfqA:
undetectable		 3w9tB-3mfqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 6 GLY A 273
LEU A 303
TYR A 307
GLU A 269
 None
 1.03A 3w9tE-3mfqA:
undetectable		 3w9tE-3mfqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 6 GLY A 273
LEU A 303
TYR A 307
GLU A 269
 None
 1.04A 3w9tF-3mfqA:
undetectable		 3w9tF-3mfqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 6 GLN A  49
ASP A 295
GLU A 182
LEU A 172
 None
 1.25A 4ax8A-3mfqA:
undetectable		 4ax8A-3mfqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 5 LYS A 152
LEU A 153
GLU A 149
LEU A  85
 None
 0.79A 4k4yA-3mfqA:
undetectable		 4k4yA-3mfqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 4 LYS A 152
LEU A 153
GLU A 149
LEU A  85
 None
 0.82A 4k4yE-3mfqA:
undetectable		 4k4yE-3mfqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 5 LYS A 152
LEU A 153
GLU A 149
LEU A  85
 None
 0.81A 4k4yI-3mfqA:
undetectable		 4k4yI-3mfqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 SER A  74
ALA A  72
VAL A  71
 None
 0.60A 4o2bA-3mfqA:
undetectable		 4o2bA-3mfqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		5 / 12 GLY A  90
GLU A  94
VAL A 108
LEU A  43
PHE A 132
 None
 1.20A 4pd9A-3mfqA:
undetectable		 4pd9A-3mfqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 HIS A 131
HIS A  68
HIS A 197
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.6A)
ZN  A 401 (-3.4A)
 0.47A 5migA-3mfqA:
undetectable		 5migA-3mfqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		3 / 3 LEU A 172
LEU A 175
TRP A 178
 None
 0.83A 5nwuA-3mfqA:
undetectable		 5nwuA-3mfqA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 6 ASN A 300
PHE A 134
LEU A 283
SER A 247
 None
 1.13A 6a7pB-3mfqA:
undetectable		 6a7pB-3mfqA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 8 TYR A  70
GLY A  95
ASP A  66
ASP A 281
 None
None
None
ZN  A 401 (-2.1A)
 0.99A 6ag0C-3mfqA:
undetectable		 6ag0C-3mfqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 5 THR A 195
HIS A 197
ASP A 281
HIS A 131
 None
ZN  A 401 (-3.4A)
ZN  A 401 (-2.1A)
ZN  A 401 (-3.4A)
 1.42A 6dchA-3mfqA:
undetectable		 6dchA-3mfqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		5 / 9 LEU A 257
THR A 231
ILE A 235
VAL A 268
ILE A 243
 None
 1.22A 6ef6A-3mfqA:
undetectable		 6ef6A-3mfqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Streptococcus
suis) 		4 / 7 GLY A  95
PHE A  93
HIS A  92
SER A 218
 None
 0.88A 6hu9S-3mfqA:
undetectable
6hu9q-3mfqA:
undetectable		 6hu9S-3mfqA:
15.16
6hu9q-3mfqA:
18.93