SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mgb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3mgb TEG12
(uncultured
soil
bacterium) 		3 / 3 ALA A  83
VAL A  85
TRP A   6
 None
 0.84A 1bdwA-3mgbA:
undetectable
1bdwB-3mgbA:
undetectable		 1bdwA-3mgbA:
4.04
1bdwB-3mgbA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 12 ILE A 196
ALA A 176
LEU A 170
PHE A 178
LEU A  22
 None
 1.08A 1rb2B-3mgbA:
undetectable		 1rb2B-3mgbA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 12 TYR A 283
ASP A  94
TYR A  87
PHE A 274
SER A 141
 None
 1.27A 1xmuA-3mgbA:
undetectable		 1xmuA-3mgbA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 12 TYR A 283
ASP A  94
TYR A  87
PHE A 274
SER A 141
 None
 1.28A 1xmuB-3mgbA:
undetectable		 1xmuB-3mgbA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 5 PRO A  11
GLY A 127
ASN A 129
GLY A 132
 None
 0.98A 1zlqA-3mgbA:
undetectable		 1zlqA-3mgbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 5 PRO A  11
GLY A 136
ASN A 129
GLY A 132
 None
 1.15A 1zlqA-3mgbA:
undetectable		 1zlqA-3mgbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 7 PHE A 120
GLU A 124
SER A 141
TRP A 142
 None
 1.21A 3dqtA-3mgbA:
undetectable
3dqtB-3mgbA:
undetectable		 3dqtA-3mgbA:
20.00
3dqtB-3mgbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 7 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 1.00A 3ln1C-3mgbA:
undetectable		 3ln1C-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 5 ARG A  90
LEU A 253
ARG A 101
ILE A 105
 PAP  A 286 (-2.7A)
None
PAP  A 286 (-2.5A)
None
 0.98A 3ln1D-3mgbA:
undetectable		 3ln1D-3mgbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 12 ILE A 196
ALA A 176
LEU A 170
PHE A 178
LEU A  22
 None
 1.15A 3ql0A-3mgbA:
undetectable		 3ql0A-3mgbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 3mgb TEG12
(uncultured
soil
bacterium) 		3 / 3 GLU A 124
GLY A 273
SER A 141
 None
 0.66A 4b53B-3mgbA:
undetectable		 4b53B-3mgbA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 10 LEU A 267
ARG A  93
PRO A  92
GLU A 124
LEU A 253
 None
 1.29A 4la0A-3mgbA:
undetectable		 4la0A-3mgbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 12 ILE A 196
ALA A 176
LEU A 170
PHE A 178
LEU A  22
 None
 1.14A 4qleA-3mgbA:
undetectable		 4qleA-3mgbA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 11 ILE A 196
ALA A 176
LEU A 170
PHE A 178
LEU A  22
 None
 1.17A 4qlfA-3mgbA:
undetectable		 4qlfA-3mgbA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3mgb TEG12
(uncultured
soil
bacterium) 		5 / 12 GLY A 140
GLY A 127
ASN A 123
ASP A  71
ALA A   8
 None
 0.97A 4uckB-3mgbA:
undetectable		 4uckB-3mgbA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3mgb TEG12
(uncultured
soil
bacterium) 		3 / 3 VAL A  85
ALA A  83
PHE A 184
 None
 0.90A 4w5nA-3mgbA:
3.4		 4w5nA-3mgbA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 7 ILE A  26
ILE A 181
ILE A   7
SER A  41
 None
 0.68A 5fukA-3mgbA:
undetectable
5fukB-3mgbA:
undetectable		 5fukA-3mgbA:
24.85
5fukB-3mgbA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 4 LEU A 256
GLY A 257
SER A 254
SER A 252
 None
 1.29A 5uunB-3mgbA:
undetectable		 5uunB-3mgbA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 5 HIS A  67
ALA A  13
SER A   9
TYR A  87
 None
PAP  A 286 (-4.8A)
PAP  A 286 ( 4.7A)
None
 1.48A 5yodF-3mgbA:
undetectable		 5yodF-3mgbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3mgb TEG12
(uncultured
soil
bacterium) 		4 / 7 SER A 141
TRP A 142
PHE A 120
GLU A 124
 None
 1.18A 6av7A-3mgbA:
undetectable
6av7B-3mgbA:
undetectable		 6av7A-3mgbA:
13.17
6av7B-3mgbA:
13.17