SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 GLY A  71
ASP A  17
GLY A 155
SER A 100
 None
 0.69A 1eswA-3mgkA:
undetectable		 1eswA-3mgkA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		4 / 6 GLY A  71
ASP A  17
GLY A 155
SER A 105
 None
 0.89A 1eswA-3mgkA:
undetectable		 1eswA-3mgkA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		3 / 3 ASP A 194
ASP A 161
ASN A 122
 None
 0.75A 2bm9D-3mgkA:
undetectable		 2bm9D-3mgkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 SER A 109
GLY A 104
THR A 103
THR A 121
LEU A   8
 None
 1.05A 2zifA-3mgkA:
undetectable		 2zifA-3mgkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 PHE A  13
GLY A  71
THR A 103
LEU A  16
VAL A 156
 None
 1.14A 2zifB-3mgkA:
undetectable		 2zifB-3mgkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 ALA A 119
ILE A  88
ASP A  17
GLY A 104
GLY A  71
 None
 1.26A 4hfpB-3mgkA:
undetectable		 4hfpB-3mgkA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 11 TYR A  57
ASP A   6
ARG A   4
ILE A  98
ILE A  63
 None
 0.88A 5hw8A-3mgkA:
undetectable
5hw8D-3mgkA:
undetectable		 5hw8A-3mgkA:
20.19
5hw8D-3mgkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 TYR A 185
GLY A 159
ASN A 122
ASP A 161
MET A 162
 None
 1.31A 5yn6A-3mgkA:
undetectable		 5yn6A-3mgkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 TYR A 185
GLY A 159
ASN A 122
ASP A 161
MET A 162
 None
 1.35A 5yniA-3mgkA:
undetectable		 5yniA-3mgkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)
(Clostridium
acetobutylicum) 		5 / 12 TYR A 185
GLY A 159
ASN A 122
ASP A 161
MET A 162
 None
 1.33A 5ynmA-3mgkA:
undetectable		 5ynmA-3mgkA:
22.44