SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		5 / 12 LEU A 359
VAL A 358
ILE A 244
VAL A 369
LEU A 389
 None
 1.09A 1s19A-3mgxA:
undetectable		 1s19A-3mgxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 PRO A  12
LEU A 286
ILE A  72
SER A  47
 None
 1.18A 1sbrA-3mgxA:
undetectable
1sbrB-3mgxA:
undetectable		 1sbrA-3mgxA:
20.19
1sbrB-3mgxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		5 / 11 VAL A  88
ASN A 231
ILE A 234
GLY A 235
THR A 239
 HEM  A 397 ( 3.8A)
GOL  A 399 (-4.2A)
GOL  A 400 ( 4.0A)
GOL  A 399 ( 3.6A)
HEM  A 397 (-3.5A)
 0.89A 1z11A-3mgxA:
29.9		 1z11A-3mgxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		5 / 11 VAL A  88
ASN A 231
ILE A 234
GLY A 235
THR A 239
 HEM  A 397 ( 3.8A)
GOL  A 399 (-4.2A)
GOL  A 400 ( 4.0A)
GOL  A 399 ( 3.6A)
HEM  A 397 (-3.5A)
 0.90A 1z11B-3mgxA:
29.8		 1z11B-3mgxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		5 / 10 VAL A  88
ASN A 231
ILE A 234
GLY A 235
THR A 239
 HEM  A 397 ( 3.8A)
GOL  A 399 (-4.2A)
GOL  A 400 ( 4.0A)
GOL  A 399 ( 3.6A)
HEM  A 397 (-3.5A)
 0.91A 1z11C-3mgxA:
30.2		 1z11C-3mgxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		5 / 10 VAL A  88
ASN A 231
ILE A 234
GLY A 235
THR A 239
 HEM  A 397 ( 3.8A)
GOL  A 399 (-4.2A)
GOL  A 400 ( 4.0A)
GOL  A 399 ( 3.6A)
HEM  A 397 (-3.5A)
 0.92A 1z11D-3mgxA:
30.2		 1z11D-3mgxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		3 / 3 SER A 280
GLU A 274
ASP A 322
 None
 0.90A 2avdB-3mgxA:
undetectable		 2avdB-3mgxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 5 SER A  47
VAL A 307
SER A  36
VAL A  34
 None
 1.14A 2j9cA-3mgxA:
undetectable
2j9cB-3mgxA:
undetectable
2j9cC-3mgxA:
undetectable		 2j9cA-3mgxA:
14.29
2j9cB-3mgxA:
14.29
2j9cC-3mgxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 7 VAL A  48
ALA A  53
PRO A 305
THR A 289
 None
 0.97A 2q6oA-3mgxA:
undetectable		 2q6oA-3mgxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 7 ILE A 120
ARG A 117
ASP A 162
GLU A 161
 None
 1.11A 2qebA-3mgxA:
undetectable		 2qebA-3mgxA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 7 ILE A 120
ARG A 117
ASP A 162
GLU A 161
 None
 1.15A 2qebB-3mgxA:
undetectable		 2qebB-3mgxA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 7 TYR A  15
LEU A   9
ASP A   8
SER A  41
 None
 1.30A 3lslA-3mgxA:
undetectable
3lslD-3mgxA:
undetectable		 3lslA-3mgxA:
20.67
3lslD-3mgxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 7 SER A  41
TYR A  15
LEU A   9
ASP A   8
 None
 1.35A 3lslA-3mgxA:
undetectable
3lslD-3mgxA:
undetectable		 3lslA-3mgxA:
20.67
3lslD-3mgxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 GLU A 274
PRO A 328
ARG A 277
HIS A 335
 None
 1.04A 3ltwA-3mgxA:
undetectable		 3ltwA-3mgxA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		3 / 3 VAL A 271
ALA A 247
PHE A 326
 None
 0.88A 4w5nA-3mgxA:
undetectable		 4w5nA-3mgxA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 VAL A  88
ILE A 234
THR A 239
ALA A 282
 HEM  A 397 ( 3.8A)
GOL  A 400 ( 4.0A)
HEM  A 397 (-3.5A)
HEM  A 397 ( 3.8A)
 0.67A 4zf8A-3mgxA:
28.5		 4zf8A-3mgxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 5 THR A 139
GLY A 142
HIS A 249
ASP A 136
 None
None
GOL  A 401 (-4.3A)
None
 1.08A 5c0oH-3mgxA:
undetectable		 5c0oH-3mgxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		5 / 12 GLY A 385
VAL A 129
GLY A 246
THR A 279
GLN A 384
 None
None
None
None
GOL  A 401 ( 4.6A)
 1.18A 5hg0A-3mgxA:
undetectable		 5hg0A-3mgxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 VAL A  89
LEU A 233
ILE A 191
PHE A 195
 None
 1.03A 5jw1A-3mgxA:
undetectable		 5jw1A-3mgxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 7 ASP A 316
PRO A 317
PHE A 320
SER A 280
 None
 1.10A 5l1fC-3mgxA:
undetectable		 5l1fC-3mgxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 4 HIS A 249
VAL A 391
LEU A 389
ALA A 252
 GOL  A 401 (-4.3A)
None
None
None
 1.41A 6d8pB-3mgxA:
undetectable		 6d8pB-3mgxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 VAL A 193
LEU A 164
LEU A 167
HIS A 188
 None
 0.99A 6e43A-3mgxA:
undetectable		 6e43A-3mgxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 VAL A 193
LEU A 164
LEU A 167
HIS A 188
 None
 1.03A 6e43B-3mgxA:
undetectable		 6e43B-3mgxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3mgx PUTATIVE P450
MONOOXYGENASE
(Amycolatopsis
balhimycina) 		4 / 6 VAL A 193
LEU A 164
LEU A 167
HIS A 188
 None
 0.98A 6e43D-3mgxA:
undetectable		 6e43D-3mgxA:
23.32