SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A  53
GLU A  31
ASP A  25
 None
 0.63A 1nt2A-3mgzA:
undetectable		 1nt2A-3mgzA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  34
ASP A  33
ILE A  23
GLY A  32
HIS A 177
 None
 1.32A 1s9aB-3mgzA:
undetectable		 1s9aB-3mgzA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 181
THR A 178
ILE A  35
HIS A 144
 None
None
None
SO4  A 300 (-4.1A)
 1.20A 2jfaB-3mgzA:
undetectable		 2jfaB-3mgzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  34
ALA A  41
VAL A 128
VAL A  59
PRO A  60
 None
 1.02A 2nnjA-3mgzA:
undetectable		 2nnjA-3mgzA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  92
THR A 107
ALA A  38
ALA A 160
LEU A  71
 None
 1.09A 2nyrA-3mgzA:
undetectable		 2nyrA-3mgzA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  25
THR A  53
GLU A  31
 None
 0.82A 2zifB-3mgzA:
undetectable		 2zifB-3mgzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 147
ILE A 163
ILE A 166
LEU A 181
ILE A  23
 None
 1.04A 3clbA-3mgzA:
undetectable		 3clbA-3mgzA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 147
ILE A 163
ILE A 166
LEU A 181
ILE A  23
 None
 1.05A 3hbbA-3mgzA:
undetectable		 3hbbA-3mgzA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3mgz 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  24
GLU A 146
SER A 168
 SO4  A 300 ( 4.9A)
SO4  A 300 ( 4.7A)
None
 0.83A 5bw4B-3mgzA:
undetectable		 5bw4B-3mgzA:
21.25