SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 6 GLU A 278
LEU A 275
VAL A  22
MET A  23
 None
None
FMN  A 313 ( 4.9A)
None
 1.07A 1hk1A-3mhuA:
undetectable		 1hk1A-3mhuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 10 GLU A 277
GLY A 223
GLY A  65
ILE A 282
LEU A 275
 None
FMN  A 313 (-3.3A)
None
None
None
 1.14A 1x7pA-3mhuA:
undetectable
1x7pB-3mhuA:
undetectable		 1x7pA-3mhuA:
21.35
1x7pB-3mhuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 SER A  43
VAL A 123
LEU A  95
 None
 0.73A 1yajG-3mhuA:
undetectable		 1yajG-3mhuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 7 ALA A 179
ARG A 240
TYR A 142
PHE A 144
 None
 1.07A 2ajvH-3mhuA:
undetectable
2ajvL-3mhuA:
undetectable		 2ajvH-3mhuA:
19.49
2ajvL-3mhuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		6 / 12 LEU A  41
GLY A 163
ALA A  20
LEU A  95
VAL A 123
ILE A 124
 None
None
FMN  A 313 (-3.5A)
None
None
None
 1.38A 3adxB-3mhuA:
undetectable		 3adxB-3mhuA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 HIS A 261
GLY A 222
GLY A 223
LEU A  64
ALA A 230
 None
FMN  A 313 (-3.6A)
FMN  A 313 (-3.3A)
None
None
 1.16A 3i5uA-3mhuA:
undetectable		 3i5uA-3mhuA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 HIS A 261
GLY A 222
GLY A 223
LEU A  64
ALA A 230
 None
FMN  A 313 (-3.6A)
FMN  A 313 (-3.3A)
None
None
 1.15A 3i5uB-3mhuA:
2.2		 3i5uB-3mhuA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 10 LEU A 227
VAL A 226
ILE A 234
ILE A 194
THR A 273
 None
None
None
None
FMN  A 313 (-3.6A)
 1.14A 3jw3A-3mhuA:
undetectable		 3jw3A-3mhuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 PHE A  96
ILE A 246
ALA A 266
VAL A   5
LEU A   8
 None
 1.25A 3s79A-3mhuA:
undetectable		 3s79A-3mhuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 8 GLY A 272
ARG A 224
PHE A 283
ILE A 282
 FMN  A 313 (-3.3A)
None
None
None
 0.93A 4j4vC-3mhuA:
undetectable		 4j4vC-3mhuA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 8 PHE A  12
GLN A 270
GLY A 248
THR A 192
 None
 0.97A 4k87A-3mhuA:
undetectable		 4k87A-3mhuA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.99A 5b3sA-3mhuA:
undetectable
5b3sJ-3mhuA:
undetectable		 5b3sA-3mhuA:
20.19
5b3sJ-3mhuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 ARG A 224
THR A 254
ASP A 257
 None
 0.92A 5g5gA-3mhuA:
undetectable
5g5gB-3mhuA:
undetectable		 5g5gA-3mhuA:
22.50
5g5gB-3mhuA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 PHE A  96
ILE A 246
ALA A 266
VAL A   5
LEU A   8
 None
 1.23A 5jkvA-3mhuA:
undetectable		 5jkvA-3mhuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 GLY A 122
TYR A  90
ASN A  10
PHE A 247
MET A 268
 None
 1.23A 5kklB-3mhuA:
undetectable		 5kklB-3mhuA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 SER A  36
ALA A  37
THR A 287
 None
 0.56A 5n0xB-3mhuA:
undetectable		 5n0xB-3mhuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 GLY A 200
VAL A 202
GLY A 222
GLY A 220
ILE A 194
 None
GOL  A 315 (-3.6A)
FMN  A 313 (-3.6A)
EJZ  A 314 ( 4.8A)
None
 0.76A 5x7fA-3mhuA:
undetectable		 5x7fA-3mhuA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 6 TYR A 253
GLU A 256
GLY A 251
GLY A 223
 None
None
FMN  A 313 (-3.7A)
FMN  A 313 (-3.3A)
 0.89A 5x7pB-3mhuA:
undetectable		 5x7pB-3mhuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 4 PHE A  96
LEU A 302
LEU A   7
VAL A 269
 None
 1.23A 5xxiA-3mhuA:
undetectable		 5xxiA-3mhuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 6 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.99A 5z86N-3mhuA:
undetectable
5z86W-3mhuA:
undetectable		 5z86N-3mhuA:
20.19
5z86W-3mhuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 6 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 1.01A 5zcoN-3mhuA:
undetectable
5zcoW-3mhuA:
undetectable		 5zcoN-3mhuA:
20.19
5zcoW-3mhuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mhu DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
major) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.97A 5zcqA-3mhuA:
undetectable
5zcqJ-3mhuA:
undetectable		 5zcqA-3mhuA:
20.19
5zcqJ-3mhuA:
12.24