SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mil'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  13
ASP A  84
LEU A  80
GLY A  81
PHE A  79
 None
 1.38A 1axwB-3milA:
undetectable		 1axwB-3milA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 200
LEU A 203
LEU A   8
PHE A  79
PHE A 191
 None
 1.08A 1bzfA-3milA:
undetectable		 1bzfA-3milA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 125
LEU A 185
GLN A  29
 None
 0.83A 3g4lA-3milA:
undetectable		 3g4lA-3milA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 203
ILE A  46
LEU A   8
LEU A  32
TYR A  30
 None
 1.00A 3k2hA-3milA:
undetectable		 3k2hA-3milA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  49
PRO A  64
PHE A   9
 None
 1.00A 3thrC-3milA:
3.7		 3thrC-3milA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 207
ALA A  17
LEU A 204
PHE A   6
LEU A   8
 None
 1.00A 3vw1B-3milA:
undetectable		 3vw1B-3milA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  81
ALA A  82
GLN A  91
ARG A  57
GLU A  97
 None
None
GOL  A 241 (-3.1A)
None
None
 1.09A 4azwA-3milA:
4.0		 4azwA-3milA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  62
ASP A  11
LEU A  80
GLY A  10
PHE A   9
 None
 1.42A 4foxE-3milA:
undetectable		 4foxE-3milA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A  44
THR A  77
ARG A 115
LEU A  32
LEU A  36
 None
 1.46A 4qynB-3milA:
undetectable		 4qynB-3milA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  79
ASP A  11
ILE A  13
GLY A 122
 None
 0.80A 4zxiA-3milA:
5.0		 4zxiA-3milA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  67
TYR A 214
PRO A 116
ILE A  78
 None
 1.09A 5esgA-3milA:
undetectable		 5esgA-3milA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 105
GLN A 104
ARG A 103
 None
 1.11A 5ewzB-3milA:
undetectable		 5ewzB-3milA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 102
GLY A  10
THR A  14
LEU A 169
 None
 0.71A 5hs1A-3milA:
undetectable		 5hs1A-3milA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 195
TYR A  30
HIS A 200
ALA A  34
ILE A 119
 None
 1.26A 5igvA-3milA:
undetectable		 5igvA-3milA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 105
GLN A 104
ARG A 103
 None
 1.13A 5m35B-3milA:
undetectable		 5m35B-3milA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 142
THR A 144
ARG A 126
ASP A 125
 None
 1.26A 5mraA-3milA:
undetectable
5mraB-3milA:
undetectable		 5mraA-3milA:
21.83
5mraB-3milA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3mil ISOAMYL
ACETATE-HYDROLYZING
ESTERASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  79
ALA A 172
PHE A 173
GLY A 122
LEU A   8
 None
 0.97A 5ul4A-3milA:
5.2		 5ul4A-3milA:
16.91