SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3mip MSO-8G
(synthetic
construct) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.36A 1hrkB-3mipA:
undetectable		 1hrkB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 12 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.22A 1hvyA-3mipA:
undetectable		 1hvyA-3mipA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 12 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.29A 1hvyB-3mipA:
undetectable		 1hvyB-3mipA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3mip MSO-8G
(synthetic
construct) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.39A 2hrcA-3mipA:
undetectable		 2hrcA-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3mip MSO-8G
(synthetic
construct) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.38A 2hrcB-3mipA:
undetectable		 2hrcB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mip MSO-8G
(synthetic
construct) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.37A 2pnjB-3mipA:
undetectable		 2pnjB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mip MSO-8G
(synthetic
construct) 		4 / 4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.35A 3hcoB-3mipA:
undetectable		 3hcoB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 9 ALA A 108
LEU A 101
ILE A  15
LEU A   7
ILE A  93
 None
 1.15A 3jw3B-3mipA:
undetectable		 3jw3B-3mipA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3mip MSO-8G
(synthetic
construct) 		4 / 5 LYS A 104
ILE A  46
PHE A  48
ASP A  22
 None
None
None
CA  A   2 ( 2.4A)
 1.18A 3kp6A-3mipA:
undetectable
3kp6B-3mipA:
undetectable		 3kp6A-3mipA:
22.70
3kp6B-3mipA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3mip MSO-8G
(synthetic
construct) 		3 / 3 TYR A  85
TYR A  26
GLU A  30
 None
 0.82A 3pfgA-3mipA:
undetectable		 3pfgA-3mipA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3mip MSO-8G
(synthetic
construct) 		4 / 7 ILE A  25
PHE A  48
LEU A  97
ILE A  93
 None
 0.82A 4rmjA-3mipA:
undetectable		 4rmjA-3mipA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 12 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.04A 5x66A-3mipA:
undetectable
5x66B-3mipA:
undetectable		 5x66A-3mipA:
17.67
5x66B-3mipA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 9 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.03A 5x66C-3mipA:
undetectable		 5x66C-3mipA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 10 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.04A 5x66D-3mipA:
undetectable		 5x66D-3mipA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3mip MSO-8G
(synthetic
construct) 		5 / 12 ILE A  61
GLY A  23
PHE A  18
TYR A  26
ALA A  45
 None
 1.03A 5x66F-3mipA:
undetectable		 5x66F-3mipA:
17.67