SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		5 / 10 GLU A 323
ILE A 319
LYS A 402
GLU A 347
GLU A 345
 None
 1.46A 2j9dD-3mixA:
undetectable
2j9dE-3mixA:
undetectable
2j9dF-3mixA:
undetectable		 2j9dD-3mixA:
16.54
2j9dE-3mixA:
16.54
2j9dF-3mixA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		4 / 4 ALA A 572
VAL A 580
PHE A 571
THR A 631
 None
 1.21A 2pkkA-3mixA:
undetectable		 2pkkA-3mixA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		4 / 6 LEU A 381
LEU A 375
ILE A 532
ARG A 533
 None
 0.98A 2rlfA-3mixA:
undetectable
2rlfB-3mixA:
undetectable		 2rlfA-3mixA:
8.92
2rlfB-3mixA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA303_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		4 / 4 ARG A 641
VAL A 644
LYS A 645
GLU A 528
 None
 1.23A 3deuA-3mixA:
0.2		 3deuA-3mixA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB304_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		4 / 4 ARG A 641
VAL A 644
LYS A 645
GLU A 528
 None
 1.21A 3deuB-3mixA:
0.0		 3deuB-3mixA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		4 / 5 LEU A 364
GLY A 362
PHE A 348
ASN A 359
 None
 1.22A 3uq6B-3mixA:
undetectable		 3uq6B-3mixA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		5 / 12 GLY A 351
ASN A 397
ILE A 353
PHE A 346
LEU A 364
 None
 1.39A 4kovA-3mixA:
undetectable		 4kovA-3mixA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		3 / 3 ASP A 327
VAL A 336
ASN A 391
 None
 0.80A 4lmnA-3mixA:
undetectable		 4lmnA-3mixA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Bacillus
subtilis) 		5 / 12 ALA A 481
LEU A 375
ALA A 376
ILE A 473
ILE A 344
 None
 0.92A 4pssA-3mixA:
undetectable		 4pssA-3mixA:
17.70