SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mjd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		4 / 5 PHE A 105
PHE A  62
LEU A 117
PHE A 128
 None
 1.34A 2y69P-3mjdA:
undetectable
2y69W-3mjdA:
undetectable		 2y69P-3mjdA:
21.86
2y69W-3mjdA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		4 / 7 ILE A 142
SER A 167
LEU A 147
VAL A 174
 None
 0.83A 3ua5B-3mjdA:
undetectable		 3ua5B-3mjdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		4 / 7 PHE A  14
GLY A  15
THR A 194
PHE A 199
 None
 1.11A 3vnsA-3mjdA:
2.4		 3vnsA-3mjdA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		3 / 3 ASP A 150
ARG A 203
THR A 163
 None
 0.67A 4i13A-3mjdA:
undetectable		 4i13A-3mjdA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		3 / 3 ASP A 150
ARG A 203
THR A 163
 None
 0.66A 4p3rA-3mjdA:
undetectable		 4p3rA-3mjdA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		5 / 12 ILE A 142
LEU A  61
VAL A 146
MET A 122
THR A 163
 None
 1.14A 5byjA-3mjdA:
undetectable		 5byjA-3mjdA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		4 / 6 PHE A   2
VAL A 177
TYR A  47
ASP A 120
 None
 1.16A 5iwuA-3mjdA:
undetectable		 5iwuA-3mjdA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 3mjd OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Francisella
tularensis) 		5 / 10 ILE A 142
LEU A  61
VAL A 146
MET A 122
THR A 163
 None
 1.26A 6b4yA-3mjdA:
undetectable		 6b4yA-3mjdA:
24.23