SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mjf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		3 / 3 VAL A 256
VAL A 251
TRP A 253
 None
 0.96A 1av2C-3mjfA:
undetectable
1av2D-3mjfA:
undetectable		 1av2C-3mjfA:
3.80
1av2D-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 GLY A 368
ASN A  34
GLY A  10
ASP A 293
VAL A 384
 None
 1.17A 1ffyA-3mjfA:
undetectable		 1ffyA-3mjfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 6 ASP A  82
GLY A  79
THR A  95
PRO A  94
 None
 0.99A 1n4fA-3mjfA:
undetectable		 1n4fA-3mjfA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 7 VAL A  81
LEU A 270
ALA A  99
LEU A  76
 None
 0.71A 1pthA-3mjfA:
undetectable		 1pthA-3mjfA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 7 VAL A  81
LEU A 270
ALA A  99
LEU A  76
 None
 0.71A 1pthB-3mjfA:
undetectable		 1pthB-3mjfA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 ILE A  53
ALA A  50
LEU A  76
THR A  68
ILE A  91
 None
 1.15A 1tdrA-3mjfA:
2.2		 1tdrA-3mjfA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		3 / 3 VAL A 256
VAL A 251
TRP A 253
 None
 0.93A 1w5uC-3mjfA:
undetectable
1w5uD-3mjfA:
undetectable		 1w5uC-3mjfA:
3.80
1w5uD-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 GLY A 368
GLY A 381
ALA A 338
ASN A   8
PHE A 365
 None
SO4  A 508 ( 4.9A)
None
None
None
 1.11A 2dpmA-3mjfA:
3.7		 2dpmA-3mjfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		3 / 3 VAL A 251
TRP A 253
VAL A 256
 None
 0.80A 2izqA-3mjfA:
undetectable
2izqB-3mjfA:
undetectable		 2izqA-3mjfA:
3.80
2izqB-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 7 LEU A 319
LEU A 312
ILE A  69
MET A 200
 None
 1.06A 2qqcG-3mjfA:
undetectable
2qqcJ-3mjfA:
undetectable		 2qqcG-3mjfA:
8.12
2qqcJ-3mjfA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		6 / 8 ASP A 214
LYS A 216
ARG A  11
GLY A 292
PRO A 294
GLU A 295
 NA  A 513 ( 3.1A)
NA  A 513 (-3.5A)
None
None
NA  A 513 (-4.4A)
NA  A 513 (-2.6A)
 1.37A 2ys6A-3mjfA:
53.1		 2ys6A-3mjfA:
52.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		3 / 3 VAL A 256
VAL A 251
TRP A 253
 None
 0.89A 3l8lA-3mjfA:
undetectable
3l8lB-3mjfA:
undetectable		 3l8lA-3mjfA:
3.80
3l8lB-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		3 / 3 VAL A 256
VAL A 251
TRP A 253
 None
 0.92A 3l8lC-3mjfA:
undetectable
3l8lD-3mjfA:
undetectable		 3l8lC-3mjfA:
3.80
3l8lD-3mjfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 PHE A 269
TYR A 271
LEU A  76
VAL A  80
LEU A   4
 None
 1.32A 3ozuA-3mjfA:
2.9		 3ozuA-3mjfA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 5 LEU A 332
GLN A 213
HIS A 215
GLY A 420
 None
GOL  A 501 (-3.8A)
GOL  A 501 (-3.9A)
None
 1.11A 3pp1A-3mjfA:
undetectable		 3pp1A-3mjfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 GLY A 273
ALA A 272
ILE A 252
VAL A 199
VAL A 251
 None
 1.01A 3ucbB-3mjfA:
undetectable		 3ucbB-3mjfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 ASP A 293
ALA A 367
ASN A  34
ILE A 419
ARG A 383
 None
None
None
None
SO4  A 508 (-3.9A)
 1.25A 3wenA-3mjfA:
undetectable		 3wenA-3mjfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 ASP A 293
ALA A 367
ASN A  34
ILE A 419
ARG A 383
 None
None
None
None
SO4  A 508 (-3.9A)
 1.25A 3weoA-3mjfA:
undetectable		 3weoA-3mjfA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A 215
GLY A 273
SER A 196
GLY A 420
ASP A 214
 GOL  A 501 (-3.9A)
None
None
None
NA  A 513 ( 3.1A)
 1.15A 4blvB-3mjfA:
undetectable		 4blvB-3mjfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 5 LEU A  15
LEU A 307
MET A 200
TRP A 326
 None
None
None
EDO  A 506 (-4.3A)
 1.39A 4do3A-3mjfA:
2.3		 4do3A-3mjfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 6 GLY A 420
GLN A 213
ILE A 424
VAL A 394
 None
GOL  A 501 (-3.8A)
None
None
 1.15A 4e1vF-3mjfA:
2.7		 4e1vF-3mjfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 9 PRO A 355
VAL A 387
VAL A 377
THR A 379
VAL A 413
 None
None
None
None
BME  A 507 ( 4.5A)
 1.29A 4oqrA-3mjfA:
undetectable		 4oqrA-3mjfA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 11 ALA A  50
PRO A  75
VAL A  70
THR A  68
ILE A   3
 None
 1.31A 4uuuB-3mjfA:
undetectable		 4uuuB-3mjfA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 4 THR A 108
ASP A 110
ARG A 114
LEU A 112
 None
 1.37A 5tdmA-3mjfA:
4.1		 5tdmA-3mjfA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 LEU A  43
THR A  37
GLY A  36
GLY A  71
PHE A 269
 None
 1.35A 5tuiB-3mjfA:
3.6		 5tuiB-3mjfA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 5 LEU A 207
LYS A 322
LEU A 310
GLU A 309
 None
 1.29A 5weaA-3mjfA:
3.8		 5weaA-3mjfA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 9 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.36A 6czmA-3mjfA:
undetectable
6czmB-3mjfA:
undetectable		 6czmA-3mjfA:
24.29
6czmB-3mjfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 9 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.36A 6czmD-3mjfA:
undetectable
6czmE-3mjfA:
undetectable		 6czmD-3mjfA:
24.29
6czmE-3mjfA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		5 / 12 ALA A  25
ASP A  26
GLY A  66
VAL A  30
ILE A  28
 None
 1.05A 6difA-3mjfA:
undetectable		 6difA-3mjfA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE
(Yersinia
pestis) 		4 / 8 ASP A 191
ARG A 422
VAL A 239
GLN A 398
 None
GOL  A 501 (-3.8A)
None
GOL  A 502 (-3.5A)
 1.24A 6fbvD-3mjfA:
undetectable		 6fbvD-3mjfA:
15.85