SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA
(Isurus
oxyrinchus;
Isurus
oxyrinchus) 		5 / 11 LEU A 127
PHE B 117
ALA A  28
VAL A  66
LEU A  17
 None
 1.35A 1hbpA-3mkbA:
undetectable		 1hbpA-3mkbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
(Isurus
oxyrinchus) 		5 / 11 SER A 117
LEU A  17
ALA A  14
ALA A  70
LEU A 128
 None
 1.03A 1jinA-3mkbA:
1.7		 1jinA-3mkbA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA
(Isurus
oxyrinchus;
Isurus
oxyrinchus) 		5 / 12 PHE A  33
ILE B 121
ALA A  28
GLU B   7
PRO A  37
 None
 1.16A 1vq1A-3mkbA:
undetectable		 1vq1A-3mkbA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
(Isurus
oxyrinchus) 		5 / 11 SER A 102
ILE A 131
SER A 132
ALA A  69
ILE A  63
 None
HEM  A 141 ( 4.6A)
None
None
None
 1.10A 2nnhA-3mkbA:
undetectable		 2nnhA-3mkbA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
(Isurus
oxyrinchus) 		4 / 6 HIS A  87
LEU A  83
LYS A  61
ALA A  65
 HEM  A 141 (-3.3A)
HEM  A 141 ( 4.8A)
HEM  A 141 ( 4.7A)
HEM  A 141 (-3.5A)
 1.26A 3gv1A-3mkbA:
undetectable
3gv1C-3mkbA:
undetectable		 3gv1A-3mkbA:
21.71
3gv1C-3mkbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
(Isurus
oxyrinchus) 		4 / 6 LEU A  83
LYS A  61
ALA A  65
HIS A  87
 HEM  A 141 ( 4.8A)
HEM  A 141 ( 4.7A)
HEM  A 141 (-3.5A)
HEM  A 141 (-3.3A)
 1.30A 3gv1A-3mkbA:
undetectable
3gv1B-3mkbA:
undetectable		 3gv1A-3mkbA:
21.71
3gv1B-3mkbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
(Isurus
oxyrinchus) 		5 / 12 LEU A 128
LEU A 106
LEU A 109
ALA A 123
GLU A   6
 None
 1.08A 5v0vA-3mkbA:
2.5		 5v0vA-3mkbA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3mkb HEMOGLOBIN SUBUNIT
ALPHA
(Isurus
oxyrinchus) 		5 / 11 GLY A  59
ALA A  26
ALA A  28
ILE A 105
VAL A  62
 None
None
None
None
HEM  A 141 (-3.8A)
 1.22A 5yk2A-3mkbA:
2.3		 5yk2A-3mkbA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3mkb HEMOGLOBIN SUBUNIT
BETA
(Isurus
oxyrinchus) 		5 / 10 ALA B  64
THR B  14
PHE B 123
PHE B 124
VAL B 127
 None
 1.19A 6hu9C-3mkbB:
undetectable		 6hu9C-3mkbB:
16.35