SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 LEU A  60
GLY A 100
ALA A  98
ASN A 173
PRO A 128
 None
None
FAD  A 500 ( 4.9A)
None
None
 1.15A 1dfoC-3mkhA:
undetectable		 1dfoC-3mkhA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 LEU A  60
GLY A 100
ALA A  98
ASN A 173
PRO A 128
 None
None
FAD  A 500 ( 4.9A)
None
None
 1.15A 1eqbA-3mkhA:
undetectable		 1eqbA-3mkhA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 LEU A  60
GLY A 100
ALA A  98
ASN A 173
PRO A 128
 None
None
FAD  A 500 ( 4.9A)
None
None
 1.15A 1eqbB-3mkhA:
undetectable		 1eqbB-3mkhA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 LEU A  60
GLY A 100
ALA A  98
ASN A 173
PRO A 128
 None
None
FAD  A 500 ( 4.9A)
None
None
 1.15A 1eqbC-3mkhA:
undetectable		 1eqbC-3mkhA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 LEU A  60
GLY A 100
ALA A  98
ASN A 173
PRO A 128
 None
None
FAD  A 500 ( 4.9A)
None
None
 1.15A 1eqbD-3mkhA:
undetectable		 1eqbD-3mkhA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 8 SER A 135
ASN A 402
ASP A 399
LYS A 356
 FAD  A 500 (-2.6A)
None
None
None
 1.12A 1hwiB-3mkhA:
undetectable		 1hwiB-3mkhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 8 SER A 135
ASN A 402
ASP A 399
LYS A 356
 FAD  A 500 (-2.6A)
None
None
None
 1.07A 1hwkA-3mkhA:
undetectable		 1hwkA-3mkhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 8 SER A 135
ASN A 402
ASP A 399
LYS A 356
 FAD  A 500 (-2.6A)
None
None
None
 1.05A 1hwkC-3mkhA:
undetectable		 1hwkC-3mkhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 8 SER A 135
ASN A 402
ASP A 399
LYS A 356
 FAD  A 500 (-2.6A)
None
None
None
 1.04A 1hwkD-3mkhA:
undetectable		 1hwkD-3mkhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 10 ALA A 274
PHE A 270
ALA A 269
LEU A 132
LEU A 353
 None
 1.05A 2bxqA-3mkhA:
2.7		 2bxqA-3mkhA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 11 SER A 273
LEU A 276
VAL A 277
MET A 280
ASP A 399
 None
 0.64A 2c12B-3mkhA:
56.8		 2c12B-3mkhA:
44.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		6 / 12 LEU A  75
LEU A 101
SER A 273
LEU A 276
VAL A 277
ASP A 399
 None
 0.85A 2c12C-3mkhA:
56.8		 2c12C-3mkhA:
44.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 10 GLY A 272
GLY A 341
SER A 424
LEU A 351
ALA A 334
 None
 0.92A 2v3kA-3mkhA:
undetectable		 2v3kA-3mkhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 THR A 391
ALA A 287
ALA A 366
GLY A 278
PRO A 396
 None
 1.28A 2ve3B-3mkhA:
undetectable		 2ve3B-3mkhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 8 LEU A  21
THR A  50
ALA A  93
ALA A  92
 None
 1.01A 3ax9B-3mkhA:
undetectable		 3ax9B-3mkhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 SER A  78
GLY A  73
GLY A  62
 None
 0.55A 3bogA-3mkhA:
undetectable
3bogC-3mkhA:
undetectable		 3bogA-3mkhA:
undetectable
3bogC-3mkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 7 ALA A 354
ALA A 274
ALA A 334
THR A 331
 None
 0.93A 4du2A-3mkhA:
undetectable		 4du2A-3mkhA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 7 ALA A 354
ALA A 274
ALA A 334
THR A 331
 None
 0.85A 4du2B-3mkhA:
undetectable		 4du2B-3mkhA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 LYS A 297
LEU A 293
ALA A 296
 None
 0.64A 4ikiA-3mkhA:
undetectable		 4ikiA-3mkhA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 TYR A  51
GLY A  62
SER A  56
GLY A 124
THR A  99
 None
 1.12A 4mm8A-3mkhA:
undetectable		 4mm8A-3mkhA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 GLY A 278
GLY A 281
GLY A 283
ALA A 274
ALA A 355
 None
 1.01A 4uciA-3mkhA:
undetectable		 4uciA-3mkhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 GLY A 278
GLY A 281
GLY A 283
ALA A 274
ALA A 355
 None
 1.01A 4uciB-3mkhA:
undetectable		 4uciB-3mkhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 ALA A 155
TRP A 162
VAL A 163
 None
 0.18A 4w9nC-3mkhA:
undetectable		 4w9nC-3mkhA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		4 / 5 ARG A 249
ARG A 244
GLY A 222
GLU A 225
 None
 1.21A 4z3oA-3mkhA:
undetectable
4z3oB-3mkhA:
undetectable		 4z3oA-3mkhA:
21.28
4z3oB-3mkhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 ASP A 271
VAL A 275
LEU A  75
 None
 0.66A 5e5jB-3mkhA:
undetectable		 5e5jB-3mkhA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 THR A 172
ALA A  98
ASN A 173
 FAD  A 500 (-3.9A)
FAD  A 500 ( 4.9A)
None
 0.43A 5ersA-3mkhA:
undetectable		 5ersA-3mkhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 LEU A 353
TYR A 345
PHE A 270
ALA A 266
LEU A 132
 None
 1.22A 5iepA-3mkhA:
undetectable		 5iepA-3mkhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 ARG A 218
PRO A 251
ASN A 254
 None
 1.06A 5jwaA-3mkhA:
undetectable
5jwaH-3mkhA:
undetectable		 5jwaA-3mkhA:
19.81
5jwaH-3mkhA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		5 / 12 ILE A  80
ALA A 362
ALA A 327
ALA A 326
PHE A 358
 None
 0.98A 5zw4A-3mkhA:
undetectable		 5zw4A-3mkhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3mkh NITROALKANE OXIDASE
(Podospora
anserina) 		3 / 3 ALA A 329
PHE A 358
GLN A 323
 None
 0.81A 6eceA-3mkhA:
undetectable		 6eceA-3mkhA:
22.30