SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 121
PHE A 156
SER A 158
VAL A 143
 None
 1.30A 1e7cA-3mkqA:
undetectable		 1e7cA-3mkqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.33A 1icuC-3mkqA:
undetectable
1icuD-3mkqA:
undetectable		 1icuC-3mkqA:
15.40
1icuD-3mkqA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.25A 1icvA-3mkqA:
undetectable
1icvB-3mkqA:
undetectable		 1icvA-3mkqA:
15.40
1icvB-3mkqA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 726
LEU A 729
ALA A 733
LEU A 715
ILE A 748
 None
 1.05A 1s9pA-3mkqA:
undetectable		 1s9pA-3mkqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 726
LEU A 729
ALA A 733
LEU A 715
ILE A 748
 None
 1.04A 1s9pD-3mkqA:
undetectable		 1s9pD-3mkqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3mkq COATOMER
BETA'-SUBUNIT
COATOMER SUBUNIT
ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 759
PHE A 743
PHE A 714
SER B 708
 None
 0.87A 1wrlC-3mkqA:
undetectable
1wrlD-3mkqA:
undetectable		 1wrlC-3mkqA:
7.72
1wrlD-3mkqA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 295
GLY A 294
GLY A  18
GLY A 290
LEU A  32
 None
 1.03A 2nxeB-3mkqA:
undetectable		 2nxeB-3mkqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 227
ASN A 188
ALA A 204
ALA A 234
SER A 245
 None
 1.13A 2r2vC-3mkqA:
undetectable
2r2vF-3mkqA:
undetectable
2r2vG-3mkqA:
undetectable		 2r2vC-3mkqA:
4.10
2r2vF-3mkqA:
4.10
2r2vG-3mkqA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 421
ASN A 405
ARG A 369
 None
 0.86A 2rlcA-3mkqA:
undetectable		 2rlcA-3mkqA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 704
LEU A 668
ALA A 686
LEU A 687
ALA A 703
 None
 1.23A 2vcvI-3mkqA:
undetectable		 2vcvI-3mkqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 295
GLY A 294
GLY A  18
GLY A 290
LEU A  32
 None
 1.06A 2zbpA-3mkqA:
undetectable		 2zbpA-3mkqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 SER A 289
GLY A 290
GLY A 246
GLY A 250
 None
 0.92A 3bogB-3mkqA:
undetectable
3bogD-3mkqA:
undetectable		 3bogB-3mkqA:
undetectable
3bogD-3mkqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 687
LEU A 674
ARG A 672
LEU A 663
 None
 1.05A 3f33A-3mkqA:
undetectable		 3f33A-3mkqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  58
GLY A  18
ILE A  19
ILE A  39
ILE A  70
 None
 0.84A 3s43A-3mkqA:
undetectable		 3s43A-3mkqA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  58
GLY A  18
ILE A  19
ILE A  39
ILE A  70
 None
 0.83A 3s54A-3mkqA:
undetectable		 3s54A-3mkqA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 548
SER A 496
SER A 535
 None
 0.93A 3ufgB-3mkqA:
undetectable		 3ufgB-3mkqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 581
TYR A 586
LEU A 345
ASN A 336
 None
 1.29A 4f8yC-3mkqA:
undetectable
4f8yD-3mkqA:
undetectable		 4f8yC-3mkqA:
13.59
4f8yD-3mkqA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 THR A 306
GLN A 360
LEU A 362
VAL A 355
TYR A 382
 None
 1.15A 4g1bA-3mkqA:
undetectable		 4g1bA-3mkqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 621
GLU A 605
GLU A 617
GLU A 614
 None
 1.22A 4mi4A-3mkqA:
undetectable		 4mi4A-3mkqA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 621
GLU A 605
GLU A 617
GLU A 614
 None
 1.23A 4mi4A-3mkqA:
undetectable
4mi4C-3mkqA:
undetectable		 4mi4A-3mkqA:
11.68
4mi4C-3mkqA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 621
GLU A 605
GLU A 617
GLU A 614
 None
 1.24A 4mj8C-3mkqA:
undetectable		 4mj8C-3mkqA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 GLU A  43
THR A   8
THR A 278
HIS A 237
 None
 1.34A 4pfjB-3mkqA:
undetectable		 4pfjB-3mkqA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 307
GLU A 304
MET A 573
LEU A 587
 None
 1.28A 4xi3B-3mkqA:
undetectable		 4xi3B-3mkqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 177
SER A 158
ALA A 157
HIS A 139
 None
 1.31A 5dzkg-3mkqA:
undetectable
5dzku-3mkqA:
undetectable		 5dzkg-3mkqA:
14.41
5dzku-3mkqA:
0.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3mkq COATOMER
BETA'-SUBUNIT
COATOMER SUBUNIT
ALPHA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ALA A 769
LYS B 719
PHE A 770
GLY B 715
SER A 773
 None
 1.10A 5hfjC-3mkqA:
undetectable		 5hfjC-3mkqA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3mkq COATOMER
BETA'-SUBUNIT
COATOMER SUBUNIT
ALPHA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ALA A 769
LYS B 719
PHE A 770
GLY B 715
SER A 773
 None
 1.11A 5hfjE-3mkqA:
undetectable		 5hfjE-3mkqA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 639
THR A 610
ARG A 612
ILE A 615
GLY A 613
 None
 1.49A 5ifuB-3mkqA:
undetectable		 5ifuB-3mkqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 183
THR A 209
ASP A 207
 None
 0.71A 5k9dA-3mkqA:
undetectable		 5k9dA-3mkqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 720
LEU A 726
GLY A 725
TYR A 746
 None
 0.94A 5x5qE-3mkqA:
undetectable		 5x5qE-3mkqA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 159
SER A 205
THR A 203
VAL A 165
 None
 1.14A 5ysiA-3mkqA:
undetectable		 5ysiA-3mkqA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 3mkq COATOMER
BETA'-SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 292
ASN A 267
LEU A 252
PHE A 233
 None
 1.03A 6ekuA-3mkqA:
4.0		 6ekuA-3mkqA:
24.08