SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		6 / 12 LEU B 992
GLY B 991
ALA B 990
ASN B 984
SER B 915
PRO B 916
 None
 1.48A 1dfoC-3mkrB:
undetectable		 1dfoC-3mkrB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		5 / 9 LEU B1033
GLY B1189
GLY B1215
PRO B1037
ILE B1054
 None
 1.01A 1hpvA-3mkrB:
undetectable		 1hpvA-3mkrB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 ASP A 200
THR A 186
GLU A 177
 None
 0.75A 1pj7A-3mkrA:
undetectable		 1pj7A-3mkrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		4 / 6 LEU A 216
LEU A 219
LEU A 239
LEU A 253
 None
 0.79A 2ab2A-3mkrA:
undetectable		 2ab2A-3mkrA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		3 / 3 VAL B1026
GLU B1023
GLU B1027
 None
 0.71A 2nv4A-3mkrB:
undetectable		 2nv4A-3mkrB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		5 / 9 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
 None
 1.09A 2vcvD-3mkrB:
2.3		 2vcvD-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		5 / 9 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
 None
 1.09A 2vcvE-3mkrB:
1.1		 2vcvE-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		5 / 9 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
 None
 1.11A 2vcvH-3mkrB:
1.1		 2vcvH-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		5 / 9 LEU B1034
PRO B1037
LEU B1038
LEU B 943
PHE B 959
 None
 1.12A 2vcvI-3mkrB:
1.3		 2vcvI-3mkrB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		4 / 5 ARG A  97
GLN A 131
PHE A 128
LEU A  91
 None
 1.44A 3ablC-3mkrA:
undetectable
3ablJ-3mkrA:
undetectable		 3ablC-3mkrA:
20.83
3ablJ-3mkrA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		5 / 12 LEU B1001
ALA B1050
SER B1035
ASP B1005
LEU B1003
 None
 1.43A 3ou6D-3mkrB:
undetectable		 3ou6D-3mkrB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		6 / 12 GLY A 195
VAL A 189
GLY A 230
ALA A 228
ALA A 224
ALA A 223
 None
 1.28A 3sudD-3mkrA:
undetectable		 3sudD-3mkrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		4 / 7 ALA B1147
ARG B1119
ALA B1122
ARG B1126
 None
 1.12A 3twpC-3mkrB:
undetectable		 3twpC-3mkrB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		5 / 12 LEU A  81
PHE A  55
GLU A  51
VAL A  50
SER A 125
 None
 1.27A 4hvcB-3mkrA:
undetectable		 4hvcB-3mkrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3mkr COATOMER SUBUNIT
ALPHA
COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		5 / 12 THR A 152
GLU A 147
TRP A 188
LEU B 973
ARG A  58
 None
 1.15A 4xi3D-3mkrA:
undetectable		 4xi3D-3mkrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		4 / 7 ALA A 185
THR A 186
VAL A 189
GLU A 177
 None
 0.59A 5ecmD-3mkrA:
undetectable		 5ecmD-3mkrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		4 / 8 ALA A 185
THR A 186
VAL A 189
GLU A 177
 None
 0.47A 5ecnD-3mkrA:
undetectable		 5ecnD-3mkrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		4 / 7 ALA A 185
THR A 186
VAL A 189
GLU A 177
 None
 0.82A 5ecoD-3mkrA:
undetectable		 5ecoD-3mkrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		4 / 7 ILE B 919
GLY B 995
PHE B1223
ASP B 929
 None
 0.91A 5hieA-3mkrB:
undetectable		 5hieA-3mkrB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 THR A 215
SER A  30
TYR A  31
 None
 0.87A 5jsdA-3mkrA:
undetectable		 5jsdA-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 THR A 215
SER A  30
TYR A  31
 None
 0.87A 5jsdB-3mkrA:
undetectable		 5jsdB-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 THR A 215
SER A  30
TYR A  31
 None
 0.87A 5jsdC-3mkrA:
undetectable		 5jsdC-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 THR A 215
SER A  30
TYR A  31
 None
 0.86A 5jseA-3mkrA:
undetectable		 5jseA-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 THR A 215
SER A  30
TYR A  31
 None
 0.87A 5jseB-3mkrA:
undetectable		 5jseB-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 THR A 215
SER A  30
TYR A  31
 None
 0.86A 5jseC-3mkrA:
undetectable		 5jseC-3mkrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3mkr COATOMER SUBUNIT
EPSILON
COATOMER SUBUNIT
ALPHA
(Bos
taurus;
Bos
taurus) 		3 / 3 HIS A 141
LYS B 905
PHE B 906
 None
 1.28A 5klaA-3mkrA:
3.4		 5klaA-3mkrA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3mkr COATOMER SUBUNIT
ALPHA
(Bos
taurus) 		4 / 5 LEU B 958
LEU B1034
MET B 940
TYR B 963
 None
 1.45A 5uc3A-3mkrB:
undetectable		 5uc3A-3mkrB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		3 / 3 HIS A 284
HIS A 281
ARG A  64
 None
 1.15A 6b58A-3mkrA:
undetectable		 6b58A-3mkrA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 3mkr COATOMER SUBUNIT
EPSILON
(Bos
taurus) 		5 / 12 LEU A  81
PHE A  55
GLU A  51
VAL A  50
SER A 125
 None
 1.32A 6mn8A-3mkrA:
undetectable		 6mn8A-3mkrA:
19.25