SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		3 / 3 ALA A 260
VAL A 262
TRP A 399
 None
 0.87A 1gmkA-3mktA:
undetectable
1gmkB-3mktA:
undetectable		 1gmkA-3mktA:
3.16
1gmkB-3mktA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		3 / 3 ALA A 260
VAL A 262
TRP A 399
 None
 0.92A 1gmkC-3mktA:
undetectable
1gmkD-3mktA:
undetectable		 1gmkC-3mktA:
3.16
1gmkD-3mktA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 LEU A  68
GLY A 295
ALA A 296
SER A 299
GLY A 303
 None
 1.11A 1igxA-3mktA:
undetectable		 1igxA-3mktA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 4 LEU A 101
PRO A 247
ILE A 239
LEU A 238
 None
 1.12A 1ya4C-3mktA:
undetectable		 1ya4C-3mktA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 10 ALA A 436
MET A 439
SER A 397
LEU A 401
VAL A 400
 None
 1.37A 2c12D-3mktA:
2.3		 2c12D-3mktA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 ILE A 343
ALA A 344
VAL A 279
ALA A 357
THR A 336
 None
 1.25A 2japA-3mktA:
undetectable		 2japA-3mktA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 ILE A 343
ALA A 344
VAL A 279
ALA A 357
THR A 336
 None
 1.24A 2japB-3mktA:
undetectable		 2japB-3mktA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 ILE A 343
ALA A 344
VAL A 279
ALA A 357
THR A 336
 None
 1.26A 2japC-3mktA:
undetectable		 2japC-3mktA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 ILE A 343
ALA A 344
VAL A 279
ALA A 357
THR A 336
 None
 1.25A 2japD-3mktA:
undetectable		 2japD-3mktA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 6 VAL A   5
LYS A   2
GLY A 313
LEU A 381
 None
 1.11A 3bjwE-3mktA:
undetectable		 3bjwE-3mktA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 GLY A 295
GLY A 313
ALA A 315
GLY A 321
LEU A 322
 None
 0.90A 3hs6B-3mktA:
undetectable		 3hs6B-3mktA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 8 PHE A 290
ALA A 372
ALA A 333
THR A 336
 None
 0.99A 3t3sF-3mktA:
undetectable		 3t3sF-3mktA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 5 LEU A  18
ALA A 296
THR A 160
PHE A 153
 None
 1.27A 3vasB-3mktA:
undetectable		 3vasB-3mktA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 7 TYR A 144
VAL A 141
LEU A 145
ASN A 178
 None
 0.97A 4e1gB-3mktA:
undetectable		 4e1gB-3mktA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 GLY A 421
GLY A 424
ALA A 276
PHE A 363
GLY A 406
 None
 1.00A 4n09B-3mktA:
undetectable		 4n09B-3mktA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 12 GLY A 313
ASN A  14
ALA A 315
ASN A 319
TYR A 445
 None
 1.39A 4pclB-3mktA:
undetectable		 4pclB-3mktA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 8 LEU A 191
GLY A 193
ALA A 201
MET A 134
 None
 0.87A 4rjdA-3mktA:
undetectable
4rjdB-3mktA:
undetectable		 4rjdA-3mktA:
9.39
4rjdB-3mktA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 8 SER A  56
THR A 130
ALA A 127
CYH A 196
GLY A 197
 None
 1.36A 5vw9A-3mktA:
undetectable		 5vw9A-3mktA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		5 / 10 PHE A 395
GLY A 383
ARG A 382
ALA A 377
LEU A 440
 None
 1.45A 5zjiA-3mktA:
undetectable
5zjiJ-3mktA:
undetectable		 5zjiA-3mktA:
12.11
5zjiJ-3mktA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 6 GLY A 321
LEU A 322
VAL A  22
PHE A 153
 None
 1.05A 6h7lA-3mktA:
undetectable		 6h7lA-3mktA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP
(Vibrio
cholerae) 		4 / 6 GLY A 321
LEU A 322
VAL A  22
PHE A 153
 None
 1.05A 6h7lB-3mktA:
undetectable		 6h7lB-3mktA:
12.89