SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 12 HIS A  65
ASP A 324
LEU A 230
MET A 193
ASP A 105
 ZN  A 425 (-3.3A)
ZN  A 425 (-2.6A)
KCX  A 191 ( 4.0A)
KCX  A 191 ( 4.0A)
None
 1.27A 1a4lB-3mkvA:
19.4		 1a4lB-3mkvA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 11 GLY A 322
THR A 274
HIS A  63
LEU A 230
GLY A 320
 None
None
ZN  A 425 (-3.2A)
KCX  A 191 ( 4.0A)
None
 1.32A 2fn1A-3mkvA:
undetectable		 2fn1A-3mkvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 6 TYR A 234
TYR A 278
GLY A 197
ASP A 203
 SO4  A 427 (-4.6A)
None
SO4  A 427 (-3.2A)
None
 1.24A 2g72A-3mkvA:
undetectable		 2g72A-3mkvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 5 LEU A 401
PRO A 400
LEU A 413
ILE A  48
 None
 0.83A 2qd4A-3mkvA:
undetectable		 2qd4A-3mkvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 11 ALA A 199
HIS A 232
GLY A 196
HIS A 140
ILE A 298
 SO4  A 427 (-3.0A)
ZN  A 426 ( 3.5A)
None
SO4  A 427 (-4.0A)
None
 1.17A 2x1lA-3mkvA:
undetectable		 2x1lA-3mkvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 12 ALA A 353
VAL A 402
GLY A 396
VAL A 276
THR A 323
 None
 0.82A 3c6gB-3mkvA:
undetectable		 3c6gB-3mkvA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		3 / 3 SER A 135
ASP A 170
ASP A 203
 None
 0.84A 3iv6A-3mkvA:
undetectable		 3iv6A-3mkvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		3 / 3 SER A 135
ASP A 170
ASP A 203
 None
 0.82A 3iv6C-3mkvA:
undetectable		 3iv6C-3mkvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 7 VAL A 378
ILE A  32
THR A   3
THR A   2
 None
 0.85A 3tneB-3mkvA:
undetectable		 3tneB-3mkvA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 12 LEU A 367
LEU A  59
ILE A  60
ALA A 353
PRO A  14
 None
 0.90A 3vrmA-3mkvA:
undetectable		 3vrmA-3mkvA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 6 GLY A 322
GLU A 336
ASP A 324
ASN A 254
 None
None
ZN  A 425 (-2.6A)
None
 1.03A 3vywC-3mkvA:
undetectable		 3vywC-3mkvA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 4 LEU A 401
PRO A 400
LEU A 413
ILE A  48
 None
 0.87A 4f4dB-3mkvA:
undetectable		 4f4dB-3mkvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 10 ALA A 374
ILE A 370
VAL A 378
ILE A  60
PRO A  14
 None
 0.97A 4j5jB-3mkvA:
undetectable		 4j5jB-3mkvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 5 LEU A 401
PRO A 400
LEU A 413
ILE A  48
 None
 0.91A 4klrA-3mkvA:
undetectable		 4klrA-3mkvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 6 GLY A 320
ASP A 324
HIS A  65
ARG A 104
 None
ZN  A 425 (-2.6A)
ZN  A 425 (-3.3A)
None
 1.00A 4lajA-3mkvA:
undetectable
4lajB-3mkvA:
undetectable		 4lajA-3mkvA:
18.54
4lajB-3mkvA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 12 GLY A 166
GLY A 107
SER A 130
LEU A 134
HIS A 140
 None
None
KCX  A 191 ( 3.9A)
KCX  A 191 ( 3.8A)
SO4  A 427 (-4.0A)
 1.04A 4qdjA-3mkvA:
undetectable		 4qdjA-3mkvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		6 / 6 HIS A  63
HIS A  65
HIS A 140
HIS A 232
HIS A 252
ASP A 324
 ZN  A 425 (-3.2A)
ZN  A 425 (-3.3A)
SO4  A 427 (-4.0A)
ZN  A 426 ( 3.5A)
ZN  A 426 (-3.6A)
ZN  A 425 (-2.6A)
 1.29A 4ubpC-3mkvA:
17.7		 4ubpC-3mkvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		4 / 5 ARG A 262
THR A 260
ALA A 261
ASP A 257
 None
 1.33A 5mfxA-3mkvA:
undetectable		 5mfxA-3mkvA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 12 ILE A 239
GLY A 253
HIS A 252
VAL A 301
ALA A 240
 None
None
ZN  A 426 (-3.6A)
None
None
 1.25A 5n0xB-3mkvA:
undetectable		 5n0xB-3mkvA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3mkv PUTATIVE
AMIDOHYDROLASE
(unidentified) 		5 / 12 ALA A 374
ILE A 370
VAL A 378
ILE A  60
PRO A  14
 None
 0.84A 5t8hB-3mkvA:
undetectable		 5t8hB-3mkvA:
14.68