SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ml6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 GLU A1172
TYR A1205
PHE A1174
 None
 0.76A 1eqbB-3ml6A:
undetectable		 1eqbB-3ml6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 GLU A1172
TYR A1205
PHE A1174
 None
 0.76A 1eqbA-3ml6A:
undetectable		 1eqbA-3ml6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 GLU A1172
TYR A1205
PHE A1174
 None
 0.75A 1eqbD-3ml6A:
undetectable		 1eqbD-3ml6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 GLU A1172
TYR A1205
PHE A1174
 None
 0.76A 1eqbC-3ml6A:
undetectable		 1eqbC-3ml6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		5 / 9 PHE A 505
GLY A 486
ALA A 424
LEU A 508
GLY A 506
 None
 1.27A 1jb0A-3ml6A:
undetectable		 1jb0A-3ml6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 VAL A 459
ASP A 460
GLU A 499
 None
 0.65A 2qeuA-3ml6A:
undetectable		 2qeuA-3ml6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 VAL A 459
ASP A 460
GLU A 499
 None
 0.63A 2qeuC-3ml6A:
undetectable		 2qeuC-3ml6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 7 VAL A1305
ILE A1324
SER A1387
THR A1433
 None
 0.82A 3deuA-3ml6A:
2.2		 3deuA-3ml6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 8 PRO A1267
SER A1204
PRO A1210
GLY A1208
 None
 0.93A 3lslA-3ml6A:
undetectable
3lslD-3ml6A:
undetectable		 3lslA-3ml6A:
22.92
3lslD-3ml6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		5 / 9 PHE A 505
GLY A 486
ALA A 424
LEU A 508
GLY A 506
 None
 1.26A 3pcqA-3ml6A:
undetectable		 3pcqA-3ml6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 8 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 0.95A 4a97C-3ml6A:
undetectable		 4a97C-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 8 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 0.93A 4a97D-3ml6A:
2.2		 4a97D-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 8 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 1.01A 4a97G-3ml6A:
undetectable		 4a97G-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 8 PHE A 469
TYR A 463
VAL A 466
MET A 430
 None
 1.05A 4a97I-3ml6A:
2.0		 4a97I-3ml6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 ALA A1368
SER A1367
VAL A1303
ILE A1386
SER A1387
 None
 1.27A 4c49A-3ml6A:
undetectable		 4c49A-3ml6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 LYS A1312
PRO A1313
SER A1314
 None
 0.51A 4k50I-3ml6A:
undetectable		 4k50I-3ml6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 8 ASP A 441
ASN A 451
ALA A 452
VAL A 504
 None
 0.74A 4zbqA-3ml6A:
undetectable		 4zbqA-3ml6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		5 / 9 ASN A 451
ILE A 488
GLY A 506
ILE A1266
THR A 491
 None
 1.15A 5kr2C-3ml6A:
undetectable		 5kr2C-3ml6A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		5 / 9 PHE A 505
GLY A 486
ALA A 424
LEU A 508
GLY A 506
 None
 1.32A 5l8rA-3ml6A:
undetectable		 5l8rA-3ml6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU
(Mus
musculus;
Rattus
norvegicus) 		4 / 6 ASN A1182
PRO A1396
VAL A1196
TYR A1431
 None
 1.18A 5umd2-3ml6A:
undetectable
5umdF-3ml6A:
undetectable		 5umd2-3ml6A:
12.85
5umdF-3ml6A:
12.54