SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mlp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 8 LEU A 192
THR A 104
ILE A 108
TYR A 110
 None
 1.06A 1qvtA-3mlpA:
undetectable		 1qvtA-3mlpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 GLY A  46
ILE A 120
THR A 122
GLN A  78
 None
 1.02A 2xrhA-3mlpA:
undetectable		 2xrhA-3mlpA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 8 GLY A  91
ILE A 108
SER A 178
THR A 156
 CIT  A   3 (-3.4A)
None
None
None
 0.70A 3d41A-3mlpA:
undetectable		 3d41A-3mlpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 4 GLN A  80
PRO A  81
VAL A  82
GLU A  83
 None
 1.29A 3huoA-3mlpA:
undetectable		 3huoA-3mlpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 ARG A 129
SER A 216
VAL A 214
VAL A 225
 None
 0.49A 3o14A-3mlpA:
undetectable		 3o14A-3mlpA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 GLY A 277
ILE A 276
VAL A 318
VAL A 286
 None
 0.77A 3ufnB-3mlpA:
undetectable		 3ufnB-3mlpA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 GLY A  46
GLN A  78
ALA A  42
ILE A 120
 None
 0.72A 4txnA-3mlpA:
undetectable		 4txnA-3mlpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 GLY A  46
GLN A  78
ALA A  42
ILE A 120
 None
 0.74A 4txnB-3mlpA:
undetectable		 4txnB-3mlpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 GLY A  46
GLN A  78
ALA A  42
ILE A 120
 None
 0.69A 4txnC-3mlpA:
undetectable		 4txnC-3mlpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 7 GLY A  46
GLN A  78
ALA A  42
ILE A 120
 None
 0.74A 4txnD-3mlpA:
undetectable		 4txnD-3mlpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		4 / 8 GLY A 283
GLN A 285
PHE A 281
SER A 250
 None
 1.03A 4wryA-3mlpA:
undetectable		 4wryA-3mlpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3mlp TRANSCRIPTION FACTOR
COE1
(Mus
musculus) 		3 / 3 VAL A 305
PHE A 335
ARG A 310
 None
 0.76A 4xr4B-3mlpA:
undetectable		 4xr4B-3mlpA:
18.70